D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide
- CAS No.
- 1173671-63-0
- Chemical Name:
- D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide
- Synonyms
- Rhosin;Rhosin (G04);Rho Inhibitor, Rhosin - Calbiochem;D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide;Rhosin /G04, (2R)-2-Amino-3-(1H-indol-3-yl)-N′-((1E)-quinoxalin-6-ylmethylidene)propanehydrazide
- CBNumber:
- CB62717274
- Molecular Formula:
- C20H18N6O
- Molecular Weight:
- 358.4
- MDL Number:
- MFCD04006470
- MOL File:
- 1173671-63-0.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H302-H315-H319-H335 |
| Precautionary statements | P261-P305+P351+P338 |
D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide price More Price(4)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 555460-M | Rho Inhibitor, Rhosin - Calbiochem | 1173671-63-0 | 25mg | $242 | 2024-03-01 | Buy |
| Crysdot | CD31004418 | Rhosin 98+% | 1173671-63-0 | 5mg | $243 | 2021-12-16 | Buy |
| CSNpharm | CSN17515 | Rhosin | 1173671-63-0 | 5mg | $336 | 2021-12-16 | Buy |
| Crysdot | CD31004418 | Rhosin 98+% | 1173671-63-0 | 10mg | $347 | 2021-12-16 | Buy |
D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide Chemical Properties,Uses,Production
Uses
Rho Inhibitor, Rhosin has been used to tre at single breast tumor cells to regulate RhoA activity to validate the cell line with the F?rster resonance energy transfer (FRET) biosensor.
Definition
ChEBI: Rhosin is a D-tryptophan derivative obtained by formal condensation of the carboxy group of D-tryptophan with the amino group of (quinoxalin-6-yl)methylidenehydrazide. It directly targets the Rho GEF binding domain, thereby preventing Rho from interacting with its GEFs It has a role as a RhoA inhibitor, a RhoC inhibitor and an antineoplastic agent. It is a D-tryptophan derivative, a quinoxaline derivative and a hydrazone.
General Description
A cell-permeable (quinoxalinylmethylidene-D-tryptophanyl)hydrazide that directly targets Rho GEF binding domain (Kd = 354 nM for RhoA), thereby prevents Rho from interacting with its GEFs (including LARG, DBL, LBC, p115 RhoGEF, and PDZ RhoGEF), but not p190RhoGAP, RhoGDI, or its effectors (ROCK, mDia, PKN, Rhoteckin). Shown to suppress mammospheres formation in MCF7, but not the non-tumorigenic MCF10A, cultures and inhibit serum-induced RhoA, RhoB, and RhoC, but not Cdc42 or Rac1, activation, MLC & PAK phosphorylation, as well as stress fiber and focal complex formation in serum-starved NIH3T3 cultures (Effective conc. 30 μM) in a reversible manner. RhoA inactivation by G04 treatment (30 μM) is also demonstrated to promote neurite outgrowth and branching from NGF-treated PC12 cells.
Biochem/physiol Actions
Primary TargetRho GTPase
D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide Preparation Products And Raw materials
Raw materials
Preparation Products
D-Tryptophan (2E)-2-(6-quinoxalinylmethylene)hydrazide Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10986 | 58 |
| TargetMol Chemicals Inc. | +8613564774135 | zijue.cai@tsbiochem.com | United States | 19881 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7787 | 56 |
| LETOPHARM LIMITED | +86-21-5821 5861 | sales@letopharm.com | China | 2384 | 58 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9923 | 65 |
| Shanghai Rechem science Co., Ltd. | 21-31433387 15618786686 | sales@rechemscience.com | China | 2991 | 58 |
| Musechem | +1-800-259-7612 | info@musechem.com | United States | 4660 | 60 |
| Fan De(Beijing) Biotechnology Co., Ltd. | 15911056312 | liming@bio-fount.com | China | 9729 | 58 |
| Absin Bioscience Inc. | 021-38015121 15000105423 | wulan@absin.cn | China | 24731 | 58 |
