A-740003
- CAS No.
- 861393-28-4
- Chemical Name:
- A-740003
- Synonyms
- CS-451;A-740003;A-740003, >=99%;A 740003; A740003;A-740003, 10 mM in DMSO;A740003 - CAS 861393-28-4 - Calbiochem;P2XRs,P2X Receptor,inhibit,A-740003,A740003,Inhibitor;(E)-N-(1-((Cyanamido(quinolin-5-ylamino)methylene)amino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyp;N-(1-(3-Cyano-2-(quinolin-5-yl)guanidino)-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide;N-[1-[[(Cyanoamino)(5-quinolinylimino)methyl]amino]-2,2-dimethylpropyl]-3,4-dimethoxybenzeneacetamide
- CBNumber:
- CB61871931
- Molecular Formula:
- C26H30N6O3
- Molecular Weight:
- 474.55
- MDL Number:
- MFCD09970333
- MOL File:
- 861393-28-4.mol
- MSDS File:
- SDS
| Melting point | 128-129 °C |
|---|---|
| Density | 1.19±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO: soluble10mg/mL, clear (warmed) |
| pka | 14.09±0.46(Predicted) |
| form | powder |
| color | white to light brown |
| FDA UNII | 532OV6WA05 |
| UNSPSC Code | 12352200 |
| NACRES | NA.77 |
A-740003 price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A0862 | A-740003 ≥98% (HPLC) | 861393-28-4 | 5mg | $132 | 2024-03-01 | Buy |
| Sigma-Aldrich | A0862 | A-740003 ≥98% (HPLC) | 861393-28-4 | 25mg | $530 | 2024-03-01 | Buy |
| Sigma-Aldrich | 5.08317 | A740003 - CAS 861393-28-4 - Calbiochem | 861393-28-4 | 5mg | $166 | 2022-05-15 | Buy |
| Cayman Chemical | 21256 | A-740003 ≥98% | 861393-28-4 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 21256 | A-740003 ≥98% | 861393-28-4 | 5mg | $116 | 2024-03-01 | Buy |
A-740003 Chemical Properties,Uses,Production
Uses
A 740003 is a potent, selective and competitive P2X7 receptor antagonist.
General Description
A-740003 is a highly affine and selective P2X7 receptor antagonist and is best for the progression of a radiotracer for imaging of neuroinflammation by positron emission tomography.
Biological Activity
Potent, selective and competitive P2X 7 receptor antagonist (IC 50 values are 18 and 40 nM for rat and human receptors respectively). Displays selectivity over a variety of P2X and P2Y receptors up to a concentration of 100 μ M. Reduces nociception in animal models of persistent neuropathic and inflammatory pain.
Biochem/physiol Actions
A-740003 is a selective P2X7 purinoceptor antagonist.
storage
Store at +4°C
References
[1]. prisca honore, diana donnelly-roberts, marian t. namovic, et al. a-740003 [n-(1-{[(cyanoimino)(5-quinolinylamino)methyl]amino}-2,2-dimethylpropyl)-2-(3,4-dimethoxyphenyl)acetamide], a novel and selective p2x7 receptor antagonist, dose-dependently reduces neuropathic pain in the rat. journal of pharmacology and experimental therapeutics, 2006, 319:1376-1385.
A-740003 Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49732 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32159 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38630 | 58 | |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 10986 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5221 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
