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ChemicalBook >> CAS DataBase List >>Cefonicid

Cefonicid

CAS No.
61270-58-4
Chemical Name:
Cefonicid
Synonyms
Monocid;Cefodie;Pratled;Monocidur;CEFONICID;SKF-75073;7-beta(r*)))-;Cefonicid USP/EP/BP;Cefonicid (free base);amino)-8-oxo-3-(((1-sulfomethyl)-1h-tetrazol-5-yl)thio)methyl)-,(6r-(6-alpha,
CBNumber:
CB5283109
Molecular Formula:
C18H18N6O8S3
Molecular Weight:
542.57
MDL Number:
MFCD00865008
MOL File:
61270-58-4.mol
MSDS File:
SDS
Last updated:2024-10-28 16:48:35

Cefonicid Properties

Density 1.92±0.1 g/cm3(Predicted)
pka -1.23±0.50(Predicted)
FDA UNII 6532B86WFG
ATC code J01DC06

Cefonicid price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation API0009116 CEFONICID 95.00% 61270-58-4 5MG $499.16 2021-12-16 Buy
Medical Isotopes, Inc. 8170 Cefonicid 61270-58-4 25mg $875 2021-12-16 Buy
Biosynth Carbosynth FC45804 Cefonicid 61270-58-4 500mg $2620 2021-12-16 Buy
Biosynth Carbosynth FC45804 Cefonicid 61270-58-4 1g $3600 2021-12-16 Buy
AHH API-1066 Cefonicid 98% 61270-58-4 1g $920 2021-12-16 Buy
Product number Packaging Price Buy
API0009116 5MG $499.16 Buy
8170 25mg $875 Buy
FC45804 500mg $2620 Buy
FC45804 1g $3600 Buy
API-1066 1g $920 Buy

Cefonicid Chemical Properties,Uses,Production

Description

Cefonicid has an unesterified D-mandelic acid moiety at C-7 and a methylsulfothiotetrazole group at C-3. The latter is related to the MTT moiety mentioned above under cefamandole nafate; however, the clotting problems and Antabuse-like side effects associated with MTT have not been reported with cefonicid. The extra acid group in the C-3 side chain leads to this molecule being sold as an injectable disodium salt. Pain and discomfort at IM sites is experienced by some patients, as is a burning sensation and phlebitis. Cefonicid has a longer half-life than the other members of its group but achieves this at the price of somewhat lower potency against Gram-positive bacteria and aerobes. The drug is somewhat unstable, needs to be protected from light and heat, and may yellow or darken. If modest, however, this does not necessarily mean that the potency has decreased significantly, but overt precipitation does. Kirby-Bauer disk testing may overestimate the sensitivity of β-lactamase–producing bacteria to this agent, so some extra caution in interpretation of laboratory results is required.

Uses

A semi-synthetic cephalosporin antibiotic related to Cefamandole. Antibacterial

Definition

ChEBI: A cephalosporin bearing {[1-(sulfomethyl)-1H-tetrazol-5-yl]sulfanyl}methyl and (R)-2-hydroxy-2-phenylacetamido groups at positions 3 and 7, respectively, of the cephem skeleton.

Antimicrobial activity

Activity against Gram-positive and Gram-negative organisms in vitro is depressed by the presence of 50% serum. It is highly bound to plasma protein (98%) and has an extended plasma half-life of 4.5–5 h. A 1 g intramuscular dose achieves a mean peak plasma concentration of around 83 mg/L. Following a 1 g intravenous bolus dose, mean peak plasma concentrations of 130–300 mg/L have been reported. In patients treated for community-acquired pneumonia, concentrations of 2–4 mg/L have been found in sputum.
It is predominantly excreted by renal secretion, 83–89% being recovered unchanged in the urine over 24 h. Plasma half-life is linearly related to creatinine clearance. As a result of its high protein binding it is not removed by hemodialysis.
It is generally well tolerated; pain on injection, rash and positive Coombs’ test are reported in some patients. It has been used to treat respiratory, soft tissue and urinary infections. Available in Italy.

Synthesis

Cefonicid, 7-D-mandelamido-3-[[(1-sulfomethyl]-1H-tetrazol-5-yl]thio] methyl]- 8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-2-carboxylic acid (32.1.2.26), is structurally similar to cefamandole and differs in the presence of a sulfonic acid group in the methyl substituent of the tetrazol ring. It is synthesized by a method analogous to that of the synthesis of cefamandole.

Cefonicid Suppliers

Global( 68)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 FandaChem@Gmail.com China 8741 55
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 49434 58
career henan chemical co 		+86-0371-86658258 +8613203830695 factory@coreychem.com China 29810 58
Hefei TNJ Chemical Industry Co.,Ltd. 		+86-0551-65418671 +8618949823763 sales@tnjchem.com China 34563 58
Shaanxi Dideu Medichem Co. Ltd 		+86-029-89586680 +86-18192503167 1026@dideu.com China 7724 58
BOC Sciences 		16314854226; +16314854226 inquiry@bocsci.com United States 19741 58
Hebei Fengjia New Material Co., Ltd 		+86-0311-87836622 +86-17333973358 sales06@hbduling.cn China 8051 58
GIHI CHEMICALS CO.,LIMITED 		+8618058761490 info@gihichemicals.com China 49982 58
Zibo Hangyu Biotechnology Development Co., Ltd 		+86-0533-2185556 +8617865335152 Mandy@hangyubiotech.com China 10986 58
LEAPCHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 43340 58

View Lastest Price from Cefonicid manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Cefonicid (free base) pictures 2024-10-28 Cefonicid (free base)
61270-58-4
 US $2500.00-1520.00 / mg 10g TargetMol Chemicals Inc.
Cefonicid pictures 2020-05-26 Cefonicid
61270-58-4
 US $0.00-0.00 / Kg 1KG 99.0% 500 MT Shaanxi Dideu Medichem Co. Ltd
Cefonicid pictures 2020-05-17 Cefonicid
61270-58-4
 US $0.00 / g 1g 98% 1kg BOC Sciences
  • Cefonicid pictures
  • Cefonicid
    61270-58-4
  • US $0.00-0.00 / Kg
  • 99.0%
  • Shaanxi Dideu Medichem Co. Ltd
  • Cefonicid pictures
  • Cefonicid
    61270-58-4
  • US $0.00 / g
  • 98%
  • BOC Sciences
CEFONICID (7r)-7-(2-hydroxy-2-phenylacetylamino)-6-oxo-3-{[1-(sulfomethyl)(1,2,3,4-tetraazol-5-ylthio)]methyl}-2h,7h,7ah-azetidino[2,1-b]1,3-thiazine-4-carboxylic acid (6R,7R)-7-[[(2R)-2-Hydroxy-2-phenylacetyl]amino]-8-oxo-3-[[[1-(sulfomethyl)-1H-tetrazol-5-yl]thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid [6R-[6α，7β(R^<*>^)]]-7- [(2-Hydroxy-2-phenylacetyl)amino]-3-[(1-sulfomethyl-1H-tetrazol-5-y1)tlfiomethyl]-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-enr2-carboxylic acid (6R,7R)-7α-[[(R)-Hydroxyphenylacetyl]amino]-8-oxo-3-[[[1-(sulfomethyl)-1H-tetrazol-5-yl]thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid Cefodie Monocid Monocidur Pratled SKF-75073 7-beta(r*)))- amino)-8-oxo-3-(((1-sulfomethyl)-1h-tetrazol-5-yl)thio)methyl)-,(6r-(6-alpha, (6R,7R)-7-[[(2R)-2-hydroxy-1-oxo-2-phenylethyl]amino]-8-oxo-3-[[[1-(sulfomethyl)-5-tetrazolyl]thio]methyl]-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid 5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid, 7-[[(2R)-2-hydroxy-2-phenylacetyl]amino]-8-oxo-3-[[[1-(sulfomethyl)-1H-tetrazol-5-yl]thio]methyl]-, (6R,7R)- Cefonicid USP/EP/BP Cefonicid (free base) 61270-58-4 61260-58-4 C18H16N6O8S3Na2 C18H18N6O8S3 API Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Sulfur & Selenium Compounds Pharmaceutical