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ChemicalBook >> CAS DataBase List >>R406

R406

CAS No.
841290-81-1
Chemical Name:
R406
Synonyms
Tamatinib;CS-735;R406, >=98%;R406 supplier;R406 tosilate;R406 besylate;Tamatinib besylate;R406, 10 mM in DMSO;R406(benzenesulfonate);Tamatinib besylate (R406)
CBNumber:
CB42546436
Molecular Formula:
C28H29FN6O8S
Molecular Weight:
628.6286632
MDL Number:
MFCD18385012
MOL File:
841290-81-1.mol
MSDS File:
SDS
Last updated:2024-11-19 15:53:33

R406 Properties

storage temp. Store at -20°C
solubility ≥31.45 mg/mL in DMSO; insoluble in H2O; ≥14.95 mg/mL in EtOH with ultrasonic
form solid
color Light yellow to khaki

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H315-H319-H335
Precautionary statements  P261-P305+P351+P338

R406 price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TRC R060000 R406 841290-81-1 2mg $110 2021-12-16 Buy
TRC R060000 R406 841290-81-1 10mg $250 2021-12-16 Buy
TRC R060000 R406 841290-81-1 50mg $675 2021-12-16 Buy
ChemScene CS-0229 R406 96.67% 841290-81-1 50mg $720 2021-12-16 Buy
Biosynth Carbosynth FR103901 R 406 841290-81-1 50mg $472.5 2021-12-16 Buy
Product number Packaging Price Buy
R060000 2mg $110 Buy
R060000 10mg $250 Buy
R060000 50mg $675 Buy
CS-0229 50mg $720 Buy
FR103901 50mg $472.5 Buy

R406 Chemical Properties,Uses,Production

Uses

R406 is a potent Syk inhibitor which affects Dectin-1-mediated signalling in mammilian cells. R406 thus acts an anti-fungal agent. Also a potential anti-leukemia agent, through modulation of sphingosine-1 phosphate receptor 1 (S1PR1).

Biological Activity

r406 is a potent syk inhibitorspleen tyrosine kinase (syk) is a non-receptor tyrosine kinase mainly expressed in hematopoietic cells. it transmits signals from a variety of cell surface receptors including cd74, fc receptor and integrins. it is crucial for adaptive immune response, and also very important for cellular adhesion, innate immune recognition, osteoclast maturation, platelet activation and vascular development. [1]functional abnormality of syk has been implicated in several blood malignancies. constitutively active syk can transform b cells. syk inhibition can be beneficial for patients with blood cancers and autoimmune diseases.r406 is a potent inhibitor of ige and igg mediated fc receptor activation with ec50 for degranulation of 56-64 nm. [2] r406 targets syk and inhibits phosphorylation of syk substrates by binding to its atp binding pocket and competing with atp. r406 strongly inhibits syk kinase activity with an ic50 of 41 nm.r406 induces apoptosis in diffuse large b-cell lymphoma cell lines. it blocks b cell receptor signaling through inhibiton of syk autophosphorylation of y525/y526 and syk-dependent phosphorylation of the b-cell linker protein. [3]r406 can be administrated orally.

target

Syk

References

[1]mocsai a, ruland j, tybulewicz vl. the syk tyrosine kinase: a crucial player in diverse biological functions. nat rev immunol 2010. 10(6): 387-402.
[2]braselmann s, taylor v, zhao h, et al. r406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation. j pharmacol exp ther 2006. 319(3): 998-1008.
[3]chen l, monti s, juszczynski p, et al. syk-dependent tonic b-cell receptor signaling is a rational treatment target in diffuse large b-cell lymphoma. blood 2008. 111(4): 2230*2237.

R406 Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 103)Suppliers
Supplier Tel Email Country ProdList Advantage
Hebei Yanxi Chemical Co., Ltd. 		+8617531153977 allison@yan-xi.com China 5855 58
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795 ivan@atkchemical.com China 33024 60
BOC Sciences 		+1-631-485-4226 inquiry@bocsci.com United States 19552 58
Neostar United (Changzhou) Industrial Co., Ltd. 		+86-0519-85551759 +8613506123987 marketing1@neostarunited.com China 8831 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 32159 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695 laboratory@coreychem.com China 30231 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 22787 58
Baoji Guokang Healthchem co.,ltd 		+8615604608665 15604608665 dominicguo@gk-bio.com CHINA 9414 58
InvivoChem 		+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6391 58
LEAP CHEM CO., LTD. 		+86-852-30606658 market18@leapchem.com China 24727 58

View Lastest Price from R406 manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
R406 besylate pictures 2025-03-07 R406 besylate
841290-81-1
 US $0.00 / kg 1kg 0.99 20tons Hebei Yanxi Chemical Co., Ltd.
R406 pictures 2024-11-19 R406
841290-81-1
 US $40.00-86.00 / mg 98.82% 10g TargetMol Chemicals Inc.
  • R406 besylate pictures
  • R406 besylate
    841290-81-1
  • US $0.00 / kg
  • 0.99
  • Hebei Yanxi Chemical Co., Ltd.
  • R406 pictures
  • R406
    841290-81-1
  • US $40.00-86.00 / mg
  • 98.82%
  • TargetMol Chemicals Inc.

R406 Spectrum

6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2-b]-1,4-oxazin-3(4H)-one benzenesulfonate R406(benzenesulfonate) 6-(5-fluoro-2-(3,4,5-trimethoxyphenylamino)pyrimidin-4-ylamino)-2,2-dimethyl-2H-pyrido[3,2-b][1,4]oxazin-3(4H)-one benzenesulfonate R406, >=98% R406 tosilate 6-[[5-Fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-2H-pyrido[3,2 R406 benzenesulfonic acid 2H-Pyrido[3,2-b]-1,4-oxazin-3(4H)-one,6-[[5-fluoro-2-[(3,4,5-trimethoxyphenyl)amino]-4-pyrimidinyl]amino]-2,2-dimethyl-, monobenzenesulfonate Tamatinib besylate (R406) CS-735 R406 supplier benzenesulfonic acid,6-[[5-fluoro-2-(3,4,5-trimethoxyanilino)pyrimidin-4-yl]amino]-2,2-dimethyl-4H-pyrido[3,2-b][1,4]oxazin-3-one R406 besylate Tamatinib Spleen tyrosine kinase,Fms like tyrosine kinase 3,Syk,FLT3,R406,inhibit,R 406,CD135,Inhibitor,Apoptosis,Cluster of differentiation antigen 135,R-406 Tamatinib besylate R406, 10 mM in DMSO 841290-81-1 C22H23FN6O5C6H6O3S C28H29FN6O8S Inhibitors