NS 1738
- CAS No.
- 501684-93-1
- Chemical Name:
- NS 1738
- Synonyms
- NS 1738;NSC 213859;NS 1738 (NSC 213859);1-(5-Chloro-2-hydroxy-phenyl)-3-(2-chloro-5-trifluoromethyl-phenyl)-urea;N-(5-Chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]urea;Urea, N-(5-chloro-2-hydroxyphenyl)-N'-[2-chloro-5-(trifluoromethyl)phenyl]-;NS 1738,Nicotinic acetylcholine receptors,NSC213859,inhibit,Inhibitor,nAChR,NS-1738,NSC-213859,NS1738
- CBNumber:
- CB42455756
- Molecular Formula:
- C14H9Cl2F3N2O2
- Molecular Weight:
- 365.13
- MDL Number:
- MFCD11100189
- MOL File:
- 501684-93-1.mol
- MSDS File:
- SDS
| Boiling point | 344.1±42.0 °C(Predicted) |
|---|---|
| Density | 1.617±0.06 g/cm3(Predicted) |
| storage temp. | Store at RT |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | White crystalline solid. |
| pka | 8.08±0.13(Predicted) |
| color | Off-White to Light Grey |
| FDA UNII | 9822RX831L |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H319 | |||||||||
| Precautionary statements | P305+P351+P338 | |||||||||
| NFPA 704 |
|
NS 1738 price More Price(26)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 5.05983 | NS1738 - CAS 501684-93-1 - Calbiochem | 501684-93-1 | 10MG | $182 | 2024-03-01 | Buy |
| Cayman Chemical | 21018 | NS 1738 ≥98% | 501684-93-1 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 21018 | NS 1738 ≥98% | 501684-93-1 | 5mg | $109 | 2024-03-01 | Buy |
| Cayman Chemical | 21018 | NS 1738 ≥98% | 501684-93-1 | 10mg | $139 | 2024-03-01 | Buy |
| Tocris | 2995 | NS1738 ≥99%(HPLC) | 501684-93-1 | 10 | $167 | 2021-12-16 | Buy |
NS 1738 Chemical Properties,Uses,Production
Description
NS 1738 is a positive allosteric modulator of the α7-containing neuronal nicotinic acetylcholine receptors (nAChRs). When applied in the presence of ACh, NS 1738 increases the peak amplitude of the current flowing through α7-containing nAChRs (EC50 = 3.4 μM). NS 1738 displays no substantial activity for α4β2-, α3β3-, and α1-containing receptors. It is modestly brain-penetrant and counteracts (-)-scopolamine-induced deficit in acquisition of a water-maze learning task in rats. NS 1738 also improves performance in the rat social recognition test. NS 1738 is used to selectively evaluate the role of α7-containing nAChRs in signaling pathways.
Uses
NS 1738 is a selective a7 nAchR allosteric modulator.
Biological Activity
Selective positive allosteric modulator of α 7 nicotinic acetylcholine receptors. Exhibits no substantial activity for α 4 β 2, α 3 β 3 and α 1-containing receptors. Displays cognitive-enhancing properties in vivo .
storage
Store at RT
NS 1738 Preparation Products And Raw materials
Raw materials
Preparation Products
NS 1738 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32956 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24727 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57505 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8447 | 60 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 5926 | 55 |
