KYNURENIC ACID
- CAS No.
- 492-27-3
- Chemical Name:
- KYNURENIC ACID
- Synonyms
- L667;NSC 58973;AKOS 235-06;KYNURENIC ACID;Quinurenic acid.;TIMTEC-BB SBB003671;KYNURENIC ACID PURE;2H5]-Kynurenic acid;4-HYDROXYQUINALDIC ACID;KynurenicAcidHydrate>
- CBNumber:
- CB3711231
- Molecular Formula:
- C10H7NO3
- Molecular Weight:
- 189.17
- MDL Number:
- MFCD00006753
- MOL File:
- 492-27-3.mol
- MSDS File:
- SDS
| Melting point | 275 °C (dec.)(lit.) |
|---|---|
| Boiling point | 324.41°C (rough estimate) |
| Density | 1.3175 (rough estimate) |
| refractive index | 1.5400 (estimate) |
| storage temp. | Sealed in dry,Room Temperature |
| solubility | DMSO : 9 mg/mL (47.58 mM; Need ultrasonic and warming) |
| form | Off-white to tan powder. |
| pka | 1.08±0.30(Predicted) |
| color | White to Gray to Brown |
| Water Solubility | 8.92g/L(100 ºC) |
| Merck | 14,5327 |
| BRN | 147451 |
| CAS DataBase Reference | 492-27-3(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | H030S2S85J |
| EPA Substance Registry System | 2-Quinolinecarboxylic acid, 4-hydroxy- (492-27-3) |
| UNSPSC Code | 41116107 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UZ9300000 | |||||||||
| HS Code | 2933.49.7000 | |||||||||
| NFPA 704 |
|
KYNURENIC ACID price More Price(21)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | K3375 | Kynurenic acid ≥98% | 492-27-3 | 250mg | $20.6 | 2024-03-01 | Buy |
| Sigma-Aldrich | K3375 | Kynurenic acid ≥98% | 492-27-3 | 5g | $163 | 2024-03-01 | Buy |
| TCI Chemical | H0303 | Kynurenic Acid Hydrate >98.0%(T)(HPLC) | 492-27-3 | 1g | $52 | 2023-06-20 | Buy |
| TCI Chemical | H0303 | Kynurenic Acid Hydrate >98.0%(T)(HPLC) | 492-27-3 | 5g | $140 | 2023-06-20 | Buy |
| Sigma-Aldrich | K3375 | Kynurenic acid ≥98% | 492-27-3 | 1g | $47.1 | 2024-03-01 | Buy |
KYNURENIC ACID Chemical Properties,Uses,Production
Uses
An antagonist of NMDA and AMPA/kainate receptors
Uses
Kynurenic acid has been used as a constituent in dissection saline solution for embryonic cerebral cortical cells and human primary astrocytes. It has also been used as a medium supplement for murine intestinal epithelial cell line, MODE-K and induced pluripotent stem cell (iPSC)-derived neurons cells.
Uses
A product of L-Tryptophan metabolism, possessing neruoactive activity having antiexcitotoxic and anticonvulsant properties.
Definition
ChEBI: Kynurenic acid is a quinolinemonocarboxylic acid that is quinoline-2-carboxylic acid substituted by a hydroxy group at C-4. It has a role as a G-protein-coupled receptor agonist, a NMDA receptor antagonist, a nicotinic antagonist, a neuroprotective agent, a human metabolite and a Saccharomyces cerevisiae metabolite. It is a monohydroxyquinoline and a quinolinemonocarboxylic acid. It is a conjugate acid of a kynurenate.
Biological Activity
Broad spectrum EAA antagonist.
Biochem/physiol Actions
Kynurenic acid (KynA) is a non-selective antagonist of N-methyl-d-aspartate (NMDA), α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) and kainate receptors. It blocks kainic acid neurotoxicity. Kynurenic acid also blocks nicotinic acetylcholine receptors. It is a by-product of tryptophan catabolic pathway. Kynurenic acid is a neuromodulator and controls the levels of glutamate, dopamine, acetylcholine and α-aminobutyric acid (GABA). KynA controls neuroendocrine functions and altered levels of KynA is a potential marker in depression, schizophrenia Alzheimer′s and Huntington′s diseases. Normal levels of KynA in the brain is crucial for the cognitive function.
storage
Room temperature
Purification Methods
Crystallise the acid from absolute EtOH. The methyl ester crystallises from MeOH with m 224-226o. [Greenstein & Winitz The Chemistry of the Amino Acids J. Wiley, Vol 3 p2723 1961, Beilstein 22 II 174, 22 III/IV 2245, 22/6 V 280.]
KYNURENIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
KYNURENIC ACID Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shaanxi Dideu Medichem Co. Ltd | +86-29-81139210 +86-18192627656 | 1059@dideu.com | China | 3003 | 58 |
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10406 | 58 |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8615195660023 | sales@senfeida.com | China | 26362 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Wuhan Fortuna Chemical Co.,Ltd | +8618007136271 | hk@fortunachem.com | China | 5999 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| Dalian Meilun Biotech Co., Ltd. | 0411-62910999 13889544652 | sales@meilune.com | China | 4730 | 58 |
| Chengdu Forest Science and Technology Development Co., Ltd. | 18030648795 18030648795 | sales@cdforestchem.com | China | 1997 | 58 |
| Wuhan ChemFaces Biochemical Co., Ltd. | 18607101326 15172504745 | aileen@chemfaces.com | China | 6905 | 55 |
View Lastest Price from KYNURENIC ACID manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-07-16 | KYNURENIC ACID
492-27-3
|
US $1.00-100.00 / KG | 1KG | 95% | 700KG | Shaanxi Dideu Medichem Co. Ltd |
-
- KYNURENIC ACID
492-27-3
- US $1.00-100.00 / KG
- 95%
- Shaanxi Dideu Medichem Co. Ltd
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