BROMOENOL LACTONE
- CAS No.
- 88070-98-8
- Chemical Name:
- BROMOENOL LACTONE
- Synonyms
- BEL;HELSS;HALOENOL LACTONE;BROMOENOL LACTONE;(6E)-Bromoenol lactone;Bromoenol lactone (BEL);Bromoenol Lactone Solution;HALOENOL LACTONE SUICIDE SUBSTRATE;HELSS, inhibitor of Ca2+ independent PLA2;(6E)-6-(bromomethylidene)-3-naphthalen-1-yloxan-2-one
- CBNumber:
- CB2471725
- Molecular Formula:
- C16H13BrO2
- Molecular Weight:
- 317.18
- MDL Number:
- MFCD00270871
- MOL File:
- 88070-98-8.mol
- MSDS File:
- SDS
| Melting point | 103-106℃ |
|---|---|
| Boiling point | 467.0±45.0 °C(Predicted) |
| Density | 1.538±0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | DMSO: Dilute in aqueous medium immediately prior to use and store on ice for no more than 12 hours.soluble |
| form | White solid. |
| color | White to yellow |
| biological source | synthetic (organic) |
| λmax | 224 nm |
| UNSPSC Code | 41106300 |
| NACRES | NA.77 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26 | |||||||||
| WGK Germany | 3 | |||||||||
| NFPA 704 |
|
BROMOENOL LACTONE price More Price(18)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | B1552 | Bromoenol lactone ≥98% (TLC) | 88070-98-8 | 5mg | $221 | 2024-03-01 | Buy |
| Alfa Aesar | J63728 | Haloenol Lactone Suicide Substrate, 98+% | 88070-98-8 | 10mg | $291 | 2021-12-16 | Buy |
| Alfa Aesar | J63728 | Haloenol Lactone Suicide Substrate, 98+% | 88070-98-8 | 5mg | $171 | 2021-12-16 | Buy |
| Cayman Chemical | 70700 | Bromoenol lactone ≥95% | 88070-98-8 | 5mg | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 70700 | Bromoenol lactone ≥95% | 88070-98-8 | 10mg | $228 | 2024-03-01 | Buy |
BROMOENOL LACTONE Chemical Properties,Uses,Production
Uses
HELSS (Haloenol lactone suicide substrate, BEL, Bromoenol lactone) is an inhibitor of Ca-independent PLA2 and Mg-dependent PAP.
Definition
ChEBI: Bromoenol lactone is a member of naphthalenes.
Biological Activity
bromoenol lactone is a potent and irreversible inhibitor of myocardial cytosolic calcium-independent phospholipase a2 (ipla2) [1].the ipla2 has been involved in stimulus-induced arachidonic acid release and lysophospholipid generation. the catalytic action of ipla2 is responsible for phospholipid remodeling as a housekeeping function. arachidonic acid and lysophospholipid generated by ipla2 act as a signaling molecule in cellular functions, including eicosanoid production, glucose-induced insulin secretion, fas-induced apoptosis, cellular proliferation, membrane traffic in fusion, contribution to myocardial ischemia, and others [2].bel promoted apoptosis in a variety of cell lines, including u937, thp-1, and monomac (human phagocyte), raw264.7 (murine macrophage), jurkat (human t lymphocyte), and gh3 (human pituitary). long term treatment with bel (up to 24 h) increased annexin-v binding to the cell surface and nuclear dna damage. bel induced the proteolysis of procaspase-9 and procaspase-3 and increased cleavage of poly (adp-ribose) polymerase [1]. bel inhibited cellular phosphatidic acid phosphohydrolase (pap) activity in intact p388d1 macrophages with an ic50 of ～8 μm. bel blocked triacylglycerol biosynthesis in p388d1 cells by decreasing diacylglycerol availability [3].
Biochem/physiol Actions
Potent, irreversible inhibitor of calcium-independent phospholipase A2 and of magnesium-dependent phosphatidate phosphohydrolase from P388D macrophages (IC50 = 8?μM); enzyme activated irreversible chymotrypsin inhibitor (Ki = 636 nM).
References
[1] fuentes l, pérez r, nieto m l, et al. bromoenol lactone promotes cell death by a mechanism involving phosphatidate phosphohydrolase-1 rather than calcium-independent phospholipase a2[j]. journal of biological chemistry, 2003, 278(45): 44683-44690.
[2] akiba s, sato t. cellular function of calcium-independent phospholipase a2[j]. biological and pharmaceutical bulletin, 2004, 27(8): 1174-1178.
[3] balsinde j, dennis e a. bromoenol lactone inhibits magnesium-dependent phosphatidate phosphohydrolase and blocks triacylglycerol biosynthesis in mouse p388d1 macrophages[j]. journal of biological chemistry, 1996, 271(50): 31937-31941.
BROMOENOL LACTONE Preparation Products And Raw materials
Raw materials
Preparation Products
BROMOENOL LACTONE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
| TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 | product@acmec-e.com | China | 33338 | 58 |
| Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52924 | 58 |
| SHANGHAI KEAN TECHNOLOGY CO., LTD. | +8613817748580 | cooperation@kean-chem.com | China | 40066 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15839 | 69 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4674 | 55 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51456 | 80 |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9923 | 65 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9806 | 58 |
View Lastest Price from BROMOENOL LACTONE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-07 | Bromoenol lactone
88070-98-8
|
US $94.00-147.00 / mg | 10g | TargetMol Chemicals Inc. | |||
 |
2024-11-07 | Bromoenol lactone
88070-98-8
|
US $94.00-147.00 / mg | 10g | TargetMol Chemicals Inc. |
-
- Bromoenol lactone
88070-98-8
- US $94.00-147.00 / mg
- TargetMol Chemicals Inc.
-
- Bromoenol lactone
88070-98-8
- US $94.00-147.00 / mg
- TargetMol Chemicals Inc.
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