VAR10300 dihydrochloride
- CAS No.
- 64821-19-8
- Chemical Name:
- VAR10300 dihydrochloride
- Synonyms
- M30 dihydrochloride;M-30 dihydrochloride;VAR10300 dihydrochloride;MAO-IN-M30 dihydrochloride;5-[[Methyl(2-propyn-1-yl)amino]methyl]-8-quinolinol Dihydrochloride;5-((Methyl(prop-2-yn-1-yl)amino)methyl)quinolin-8-ol dihydrochloride;5-[N-methyl-N-propargylaminomethyl]-8-hydroxyquinoline dihydrochloride;N-(8-Hydroxy-5-quinolylmethyl)-N-methyl-2-propynylamine dihydrochloride
- CBNumber:
- CB22750653
- Molecular Formula:
- C14H15ClN2O
- Molecular Weight:
- 262.74
- MDL Number:
- MFCD20488063
- MOL File:
- 64821-19-8.mol
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS05,GHS07 |
|---|---|
| Signal word | Danger |
| Hazard statements | H302-H318 |
| Precautionary statements | P280-P301+P312+P330-P305+P351+P338+P310 |
| Hazard Codes | Xn |
| Risk Statements | 22-41 |
| Safety Statements | 26-39 |
| WGK Germany | 3 |
VAR10300 dihydrochloride price More Price(6)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0128 | M30 dihydrochloride ≥98% (HPLC) | 64821-19-8 | 5mg | $132 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML0128 | M30 dihydrochloride ≥98% (HPLC) | 64821-19-8 | 25mg | $516 | 2024-03-01 | Buy |
| Tocris | 6067 | M30 dihydrochloride ≥98%(HPLC) | 64821-19-8 | 25 | $374 | 2021-12-16 | Buy |
| Tocris | 6067 | M30 dihydrochloride ≥98%(HPLC) | 64821-19-8 | 5 | $96 | 2021-12-16 | Buy |
| TRC | M320758 | M30 dihydrochloride | 64821-19-8 | 1mg | $95 | 2021-12-16 | Buy |
VAR10300 dihydrochloride Chemical Properties,Uses,Production
Uses
M 30 Dihydrochloride is a potent and brain selective monoamine oxidase (MAO) inhibitor (EC50 values are 37 and 57 nM for MAO-A and MAO-B, respectively). Also an iron chelator with antioxidant properties. Protects cells against 6-OHDA (Cat. No. 2547) induced apoptosis. Attenuates MPTP depletion of DA and increases striatal monoamine levels in a mouse Parkinson''s disease model.
Biological Activity
M30 is a site-activated iron chelator and monoamine oxidase (MAO) inhibitor; with neuroprotective and anti-apoptotic activity. It is a multifunctional non-toxic, brain permeable iron chelator possessing a neuroprotective propargylamine moiety and an antioxidant-iron chelator moiety. M30 is a selective irreversible inhibitor of mitochondrial brain monoamine oxidases A and B (MAO-A and -B), providing for improved levels of neurotransmitters. It reduces oxidative damage and shows neuroprotective and neurorestorative effects in various neurodegenerative models of ALS, Alzheimerμs and Parkinsonμs diseases, and is being investigated in other diseases where oxidative stress is a problem.
in vivo
MAO-IN-M30 (0.5-2.5 mg/kg; p.o.; once daily for 14 consecutive days) possesses neuroprotective activities[6].
| Animal Model: | Male C57/BL mice (20-22 g; MPTP-induced neurotoxicity in mice)[6] |
| Dosage: | 0.5, 2.5 mg/kg |
| Administration: | P.o.; once daily for 14 consecutive days |
| Result: | Significantly elevate striatal dopamine levels, reduce its metabolism, and elevate tyrosine-hydroxylase protein levels and activity. Elevated MPTP-reduced dopaminergic and transferrin receptor cell count in the SNpc. |
IC 50
MAO-A: 37 nM (IC50); MAO-B: 57 nM (IC50)
storage
Store at -20°C
VAR10300 dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
VAR10300 dihydrochloride Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32302 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 57505 | 58 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 71826 | 60 |
| Shanghai SuperLan Chemcial Technique Centre | 021-2022843681 15618226720 | lucy@atkchemical.com | China | 10017 | 58 |
| Chuzhou KeMail Chemical Technology Co., Ltd | 0550-5196001 15000891977 | wj520wjxby@126.com | China | 1940 | 55 |
| Shanghai Hongye Biotechnology Co. Ltd | 400-9205774 | sales@glpbio.cn | China | 6777 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 +86-13028896684; | sales@rrkchem.com | China | 57422 | 58 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Changzhou Chenhong Biotechnology Co., Ltd. | 0519-85788828 13775037613 | sales@chemrenpharm.com | China | 3907 | 58 |
| Beijing Jin Ming Biotechnology Co., Ltd. | 010-60605840 15801484223; | psaitong@jm-bio.com | China | 29770 | 58 |
View Lastest Price from VAR10300 dihydrochloride manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-11-11 | MAO-IN-M30 dihydrochloride
64821-19-8
|
US $30.00-97.00 / mg | 98.43% | 10g | TargetMol Chemicals Inc. |
-
- MAO-IN-M30 dihydrochloride
64821-19-8
- US $30.00-97.00 / mg
- 98.43%
- TargetMol Chemicals Inc.