ETILEFRINE-D5
- CAS No.
- 709-55-7
- Chemical Name:
- ETILEFRINE-D5
- Synonyms
- S 40032;Etilefrin;S 40032-7;Aids001656;Etilephrine;Aids-001656;dl-Etilefrin;Etiladrianol;Etilefrin-d5;ETILEFRINE-D5
- CBNumber:
- CB0495639
- Molecular Formula:
- C10H15NO2
- Molecular Weight:
- 181.23
- MDL Number:
- MFCD08063567
- MOL File:
- 709-55-7.mol
- MSDS File:
- SDS
| Melting point | 147-148° |
|---|---|
| Boiling point | 314.35°C (rough estimate) |
| Density | 1.0918 (rough estimate) |
| refractive index | 1.5464 (estimate) |
| pka | 9.81±0.10(Predicted) |
| LogP | 3.2 at 25℃ and pH5.5 |
| FDA UNII | ZB6F8MY53V |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS06 |
|---|---|
| Signal word | Danger |
| Hazard statements | H301-H412 |
| Precautionary statements | P264-P270-P301+P310-P321-P330-P405-P501-P273-P501 |
ETILEFRINE-D5 price More Price(1)
ETILEFRINE-D5 Chemical Properties,Uses,Production
Originator
Circupon,Troponwerke,W. Germany
Uses
Etilefrin is a sympathomimetic drug that increases the pulse rate, cardiac output, stroke volume, central venous pressure and mean arterial pressure of healthy individuals. Etilefrin has both beta 1 and alpha adrenergic effects on humans and is mainly used for the treatment of patients with orthostatic hypotension.
Uses
ETILEFRINE-D5 is a sympathomimetic drug that increases the pulse rate, cardiac output, stroke volume, central venous pressure and mean arterial pressure of healthy individuals. Etilefrin has both beta 1 and alpha adrenergic effects on humans and is mainly used for the treatment of patients with orthostatic hypotension.
Definition
ChEBI: 3-[2-(ethylamino)-1-hydroxyethyl]phenol is a member of phenols.
Manufacturing Process
30 parts of 1-(3'-hydroxyphenyl)-2-(N-benzylaminomethyl)-ethan-1-one are
mixed with 100 parts of pyridine and 30 parts of pivalic anhydride and
dissolved while warming. After heating for 1 hour under reflux, the acylation
is complete. After concentrating the reaction solution, the product is
precipitated from acetone/ether. Yield: 96.4% of 1-(3'-pivaloyloxyphenyl)-2-
(N-benzylaminomethyl)-ethan-1-one.
3 parts of palladium/charcoal (10% strength) are prehydrogenated in water,
thereafter 10 parts of 1-(3'-pivaloyloxyphenyl)-2-(N-benzylaminoethyl)-ethan-
1-one, dissolved in a 10-fold amount of water, are added dropwise at room
temperature and hydrogenation is carried out until 1 mol of hydrogen has
been taken up. After filtering off the catalyst, a further 3 parts of
palladium/charcoal are added and hydrogenation is carried out until a further
mol of hydrogen has been taken up. The catalyst is separated off and after
removal of the solvent the hydrogenation product is reprecipitated from
acetone/petroleum ether and from methanol/ether until it is pure according to
thin layer chromatography. Yield: 38.8% of 1-(3'-pivaloyloxyphenyl)-2-
ethylaminoethanol-1 hydroxide, melting point 208°C to 209°C.
Therapeutic Function
Tranquilizer
ETILEFRINE-D5 Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| AFINE CHEMICALS LIMITED | +86-0571-85134551 | sales@afinechem.com | China | 15352 | 58 |
| LEAPCHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 43340 | 58 |
| XIAMEN AMITY INDUSTRY AND TRADE CO., LTD. | +8618950047208 | ellena@amitychem.com | China | 43416 | 58 |
| Shanghai TaoSu Biochemical Technology Co., Ltd. | 021-33632979 | info@tsbiochem.com | China | 8065 | 58 |
| Shenzhen Polymeri Biochemical Technology Co., Ltd. | +86-400-002-6226 +86-13028896684; | sales@rrkchem.com | China | 57423 | 58 |
| Beijing xinyanhui pharmaceutical research and development co., LTD | 13969155946 | 1461866103@qq.com | China | 16111 | 58 |
| Block Chemical Technology (Shanghai) Co., Ltd. | 021-20432219 13918097649 | li_jinfei@acblock-lab.com | China | 10034 | 58 |
| Shanghai Haohong Scientific Co., Ltd. | 400-400-8210725 17717813675; | malulu@leyan.com | China | 39988 | 58 |
| Shanghai Titan Scientific Co.,Ltd | 16621234537 | chenyj@titansci.com | China | 5629 | 58 |