8-Bromo-5-fluoro-2,2-dimethyl-benzo[1,3]dioxin-4-one Chemische Eigenschaften,Einsatz,Produktion Methoden

Synthese

3-bromo-6-fluoro-2-hydroxybenzoic acid (25 g, 106.38 mmol, 1 eq) was dissolved in a mixed solution of DMF (1.5 mL) and acetone (63.20 g, 1.09 mol, 80 mL, 10.23 eq). At 0°C, TFAA (151.00 g, 718.94 mmol, 100 mL, 6.76 eq) and TFA (10 mL) were added dropwise to the mixed solution. The temperature of the mixed solution was raised to 100°C and stirred for 12 hours. The mixed solution was poured into saturated Na2CO3(500 mL) and stirred for 10 minutes. Then extract with ethyl acetate (150 mL×2). The combined organic phases were washed with brine (15 mL x 2), dried over anhydrous Na2SO4, filtered, and concentrated in vacuo. The crude product after the residue was purified by column chromatography (SiO2, petroleum ether/ethyl acetate=1/0 to 20/1) was washed with PE (40 mL), filtered and the filter cake was dried under reduced pressure to obtain 8-Bromo-5-fluoro-2,2-dimethyl-benzo[1,3]dioxin-4-one.

8-Bromo-5-fluoro-2,2-dimethyl-benzo[1,3]dioxin-4-one Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

8-Bromo-5-fluoro-2,2-dimethyl-benzo[1,3]dioxin-4-one Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Shanghai Gubang New Materail Technology Co. LTD	21-51317962 +8618721305404	16728589@qq.com	CHINA	272	58
Jurong Coupling Biotechnology Co., Ltd.	19231718652	278191416@qq.com	China	475	58
Nanjing Asfam Pharmaceutical Technology Co., Ltd.	025-58867862 18751812725	sales@ace-pharm.com	China	2000	58
Shanghai Gugang New Materials Technology Co. Ltd.	021-51317962	296935822@qq.com	China	979	58
Shanghai Minhan Pharmaceutical Technology Co., Ltd.	176121882	2816925681@qq.com	China	2721	58
Birdo (Shanghai) Medical Technology Co., Ltd.	021-58099077-8041 18601625411	sales@birdotech.com	China	9483	58
Taizhou Nanfeng Pharmaceutical Research Institute	18616377689	nanfengdrug@163.com	China	20010	58
Shanghai meikai technology co., ltd	021-18721550-091 18721550091	yangdong@pharma.com	China	4121	58
Shanghai Jiyu Medical Technology Co., Ltd	19512315373	wzy@shjypharm.com	China	92	58
Nanjing Pope Bio-tech R&D Co., Ltd	18951783565 18951783565	sales@popebiotech.com	China	1121	58

---

• 8-Bromo-5-fluoro-2,2-dimethyl-benzo[1,3]dioxin-4-one
• 4H-1,3-Benzodioxin-4-one, 8-bromo-5-fluoro-2,2-dimethyl-
• 8-Br-5-F-2,2-dimethyl-4H-1,3-benzodioxin-4-one
• 8-bromo-5-fluoro-2,2-dimethyl-4H-benzo[d][1,3]dioxin-4-one
• 2006317-76-4