Florbenazine

937245-42-6

CAS-Nr.: 937245-42-6

Englisch Name:: Florbenazine

Synonyma:: Florbenazine;(2R,3R,11bR)-9-(3-fluoropropoxy)-3-isobutyl-10-methoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol;2H-Benzo[a]quinolizin-2-ol, 9-(3-fluoropropoxy)-1,3,4,6,7,11b-hexahydro-10-methoxy-3-(2-methylpropyl)-, (2R,3R,11bR)-

CBNumber:: CB93166380

Summenformel:: C21H32FNO3

Molgewicht:: 365.48

MOL-Datei:: 937245-42-6.mol

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Eigenschaften Sicherheit Verwendungswort Produktionsfirma 6

Florbenazine Eigenschaften

Siedepunkt:: 496.0±45.0 °C(Predicted)

Dichte: 1.14±0.1 g/cm3(Predicted)

pka: 14.75±0.40(Predicted)

InChI: InChI=1S/C21H32FNO3/c1-14(2)9-16-13-23-7-5-15-10-21(26-8-4-6-22)20(25-3)11-17(15)18(23)12-19(16)24/h10-11,14,16,18-19,24H,4-9,12-13H2,1-3H3/t16-,18-,19-/m1/s1

InChIKey: GNKGXQHHUUEYQV-BHIYHBOVSA-N

SMILES: C12=CC(OC)=C(OCCCF)C=C1CCN1[C@]2([H])C[C@@H](O)[C@H](CC(C)C)C1

Sicherheit

Florbenazine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Florbenazine (AV-133) is a fluorinated VMAT-2 ligand for PET. It is designed to measure dopaminergic degeneration by in vivo assessment of striat VMAT2 density in patients with Parkinson’s disease (PD). Besides differentiating PD from essential tremor and drug-induced parkinsonism, PET imaging of VMAT2 may help in differentiating Dementia with Lewy Bodies (DLB) from Alzheimer’s disease. AV-45 (florbetapir, AmyvidTM) is the first PET ligand to receive US FDA approval to assess neuritic plaque amyloid[1-2].

Florbenazine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

Florbenazine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 6)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32965	60
Amadis Chemical Company Limited	571-89925085	sales@amadischem.com	China	131957	58
Shanghai Chaolan Chemical Technology Center	021-QQ：65489617 15618227136	Sales@ATKchemical.com	China	7312	58
Hubei Chuangliankangcheng Pharmaceutical Co., Ltd.	027-65388397 18164111589	3321478047@qq.com	China	1993	55
Shanghai SuperLan Chemcial Technique Centre	021-2022843681 15618226720	lucy@atkchemical.com	China	9987	58
Jiangsu Aikon Biopharmaceutical R&D Co.,Ltd.	025-66061636 18013972705	qqyang@aikonchem.com	China	10238	58

(2R,3R,11bR)-9-(3-fluoropropoxy)-3-isobutyl-10-methoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-ol
Florbenazine
2H-Benzo[a]quinolizin-2-ol, 9-(3-fluoropropoxy)-1,3,4,6,7,11b-hexahydro-10-methoxy-3-(2-methylpropyl)-, (2R,3R,11bR)-
937245-42-6

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