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5-fluoro-2-(2-morpholino-5-(morpholinosulfonyl)phenyl)benzo[d]isothiazol-3(2H)-one

5-fluoro-2-(2-morpholino-5-(morpholinosulfonyl)phenyl)benzo[d]isothiazol-3(2H)-one Struktur
1632125-79-1
CAS-Nr.
1632125-79-1
Englisch Name:
5-fluoro-2-(2-morpholino-5-(morpholinosulfonyl)phenyl)benzo[d]isothiazol-3(2H)-one
Synonyma:
5-fluoro-2-(2-morpholino-5-(morpholinosulfonyl)phenyl)benzo[d]isothiazol-3(2H)-one;5-fluoro-2-(2-morpholin-4-yl-5-morpholin-4-ylsulfonylphenyl)-1,2-benzothiazol-3-one;1,2-Benzisothiazol-3(2H)-one, 5-fluoro-2-[2-(4-morpholinyl)-5-(4-morpholinylsulfonyl)phenyl]-
CBNumber:
CB93146773
Summenformel:
C21H22FN3O5S2
Molgewicht:
479.54
MOL-Datei:
1632125-79-1.mol

5-fluoro-2-(2-morpholino-5-(morpholinosulfonyl)phenyl)benzo[d]isothiazol-3(2H)-one Eigenschaften

Siedepunkt:
711.7±70.0 °C(Predicted)
Dichte
1.481±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
DMF: 5 mg/ml; DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml; DMSO: 1 mg/ml
Aggregatzustand
A crystalline solid
pka
1.49±0.40(Predicted)
Farbe
White to off-white

Sicherheit

5-fluoro-2-(2-morpholino-5-(morpholinosulfonyl)phenyl)benzo[d]isothiazol-3(2H)-one Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Insulin-degrading enzyme (IDE) is a thiol-sensitive zinc-metallopeptidase that acts as the major insulin-degrading protease in vivo, mediating the termination of insulin signaling. In addition to regulating insulin action in diabetes pathogenesis, IDE plays a role in Varicella-Zoster virus infection and degradation of amyloid-β, a peptide implicated in Alzheimer’s disease. ML-345 is a small molecule inhibitor that selectively targets cysteine819 in IDE with an EC50 value of 188 nM. It demonstrates 10-fold selectivity for IDE over a panel of enzymes with reactive cysteine residues.

Verwenden

ML345 is a small molecule inhibitor of the insulin-degrading enzyme (IDE).

5-fluoro-2-(2-morpholino-5-(morpholinosulfonyl)phenyl)benzo[d]isothiazol-3(2H)-one Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

5-fluoro-2-(2-morpholino-5-(morpholinosulfonyl)phenyl)benzo[d]isothiazol-3(2H)-one Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 12)Lieferanten
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Changzhou Furuisi Biotechnology Co., Ltd 0519-85524369
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TargetMol Chemicals Inc. 4008200310
 marketing@tsbiochem.com China 24644 58
  • 5-fluoro-2-(2-morpholino-5-(morpholinosulfonyl)phenyl)benzo[d]isothiazol-3(2H)-one
  • 5-fluoro-2-(2-morpholin-4-yl-5-morpholin-4-ylsulfonylphenyl)-1,2-benzothiazol-3-one
  • 1,2-Benzisothiazol-3(2H)-one, 5-fluoro-2-[2-(4-morpholinyl)-5-(4-morpholinylsulfonyl)phenyl]-
  • 1632125-79-1
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