Monoclonal Anti-CD11b Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Anti-CD11b-FITC antibody is suitable for flow cytometric analysis of CD11b expression in RA-induced differentiation of human promyelocytic leukemia cells. It is also suitable for flow cytometric analysis of spleen cells to study the beneficial effects of dietary consumption of n-3 polyunsaturated fatty acids (PUFA) and two selective estrogen receptor modulator (SERM) derivatives.
Allgemeine Beschreibung
CD11b is an α/β heterodimeric glycoprotein. It belongs to the β2 integrin family and also referred as Mac-1, CR3, MO-1, and C3bi receptor.
Biochem/physiol Actions
Anti-CD11b-FITC antibody is expressed on the surface of circulating monocytes, granulocytes, and certain NK cells. It is also present on subsets of macrophages and in subcellular granules of granulocytes. Upon activation, it translocates to the surface. It forms a CD11b/CD18 complex to participate in a variety of cell-cell and cell-substrate interactions such as attachment and phagocytosis of particles coated with C3bi by granulocytes and macrophages and phagocytosis of opsonized pathogens. It also plays a role in the initiation of a coagulation protease cascade and in cell migration mechanisms.
Monoclonal Anti-CD11b Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
