QUISQUALIC ACID
|
|
QUISQUALIC ACID Eigenschaften
- Schmelzpunkt:
- 185-187°C dec.
- alpha
- D20 +17.0° (c = 2.0 in 6M HCl)
- Siedepunkt:
- 324.36°C (rough estimate)
- Dichte
- 1.6649 (rough estimate)
- Brechungsindex
- 1.6190 (estimate)
- storage temp.
- 2-8°C
- L?slichkeit
- NH4OH 1 M: 20 mg/mL, clear, colorless
- pka
- 2.12±0.10(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to off-white
- Wasserl?slichkeit
- Soluble in ethanol, water. Insoluble in organic solvents.
- Merck
- 13,8177
- BRN
- 1078734
- Stabilit?t:
- Stable. Incompatible with strong oxidizing agents.
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
Bildanzeige (GHS) | |||||||||||||||||||||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Alarmwort | Warnung | ||||||||||||||||||||||||||||
Gefahrenhinweise |
|
||||||||||||||||||||||||||||
Sicherheit |
|
QUISQUALIC ACID Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
L-Quisqualic acid is a natural analog of glutamate that acts as an agonist at AMPA-selective and metabotropic glutamate receptors (EC50s = 170, 10, 40, and 29 nM at GluR-A, mGluR1, mGluR3, and mGluR5, respectively), as well as the ionotropic kainate receptor (GRIK4; Ki = 6.43 nM). L-Quisqualic acid is used to study receptor dynamics and as an excitotoxin to selectively destroy neurons in the brain or spinal cord.Chemische Eigenschaften
Off-White SolidVerwenden
Quisqualic acid is used to differentiate between mGluR-1 and mGluR-4. L-Quisqualic acid is an activator of GluR.Allgemeine Beschreibung
Quisqualate/ Quisqualic acid is obtained from the fruits and seeds of Quisqualis chinensis. It is an agonist at two subsets of excitatory amino acid receptors metabotropic receptors that indirectly mediate calcium mobilization from intracellular stores and, ionotropic receptors that directly control membrane channels. L-quisqualic acid is an agonist of the neurotransmitter L-glutamate.Biologische Aktivit?t
Glutamate receptor agonist acting at AMPA receptors and metabotropic glutamate receptors positively linked to phosphoinositide hydrolysis. Sensitizes neurons in hippocampus to depolarization by L-AP6 (the so called 'quis' effect). Also available as part of the Group I mGlu Receptor Tocriset™ .l?uterung methode
It has been purified by ion-exchange chromatography on Dowex 50W (x 8, H+ form); the desired fractions are lyophilised and recrystallised from H2O/EtOH. It has IR (KBr) : 3400-2750br, 1830s, 1775s, 1745s and 1605s cm-1;maxand 1H NMR (NaOD/D2O, pH 13) : 3.55-3.57 (1H m, X of ABX, H-2), 3.72-3.85 (2H, AB of ABX, H-3), 1 3C NMR (D2O) : 50.1t, 53.4d, 154.8s, 159.7s and 171.3s. [Baldwin et al. J Chem Soc, Chem Commun 256 1985.] It is a quasiqualate receptor agonist [Joels et al. Proc Natl Acad Sci USA 86 3404 1989].QUISQUALIC ACID Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
QUISQUALIC ACID Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 138)Lieferanten
Firmenname | Telefon | Land | Produktkatalog | Edge Rate | |
---|---|---|---|---|---|
Hubei Jusheng Technology Co.,Ltd. | 18871490254 |
linda@hubeijusheng.com | CHINA | 28172 | 58 |
career henan chemical co | +86-0371-86658258 +8613203830695 |
factory@coreychem.com | China | 29810 | 58 |
Shanghai UCHEM Inc. | +862156762820 +86-13564624040 |
sales@myuchem.com | China | 7712 | 58 |
Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 |
1026@dideu.com | China | 22787 | 58 |
Nextpeptide Inc | +86-0571-81612335 +8613336028439 |
sales@nextpeptide.com | China | 19908 | 58 |
Labnetwork lnc. | +86-27-50766799 +8618062016861 |
contact@labnetwork.com | China | 19987 | 58 |
Henan Aochuang Chemical Co.,Ltd. | +86-0371-63689365 +8618638391208 |
sales@aochuangchem.com | China | 9245 | 58 |
Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 |
masar@topule.com | China | 8467 | 58 |
LEAPCHEM CO., LTD. | +86-852-30606658 |
market18@leapchem.com | China | 43340 | 58 |
Shanghai Acmec Biochemical Technology Co., Ltd. | +86-18621343501; +undefined18621343501 |
product@acmec-e.com | China | 33338 | 58 |
52809-07-1()Verwandte Suche:
- 3-(3,5-DIOXO-1,2,4-OXADIAZOLIDIN-2-YL)-L-ALANINE
- L(+)-QUISQUALIC ACID
- L-QUISQUALIC ACID
- L-(+)-A-AMINO-3,5-DIOXO-1,2,4-OXADIAZOLIDINE-2-PROPANOIC ACID
- (L)-(+)-ALPHA-AMINO-3,5-DIOXO-1,2,4-OXADIAZOLIDINE-2-PROPANOIC ACID
- BETA-[3,5-DIOXO-1,2,4-OXADIAZOLIDIN-2-YL]-L-ALANINE
- BETA-(3,5-DIOXO-1,2,4-OXADIZOLIDIN-2-YL)-L-ALANINE
- (+)-QUISQUALIC ACID
- QUISQUALIC ACID
- L-(+)-a-Amino-3,5-Dioxo-1,2,4-oxadiazolidine-2-pro
- β-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)-l-alanine
- QUISQUALATE
- L-(+)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic Acid
- β-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine, 3-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine
- (S)-2-Amino-3-(3,5-dioxotetrahydro-1,2,4-oxadiazole-2-yl)propionic acid
- (αS)-α-Amino-3,5-dioxo-1,2,4-oxadiazolidine-2-propanoic acid
- (αS)-α-Amino-3,5-dioxotetrahydro-1,2,4-oxadiazole-2-propionic acid
- Quisqualic acid,β-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine, 3-(3,5-Dioxo-1,2,4-oxadiazolidin-2-yl)-L-alanine
- (S)-2-aMino-3-(3,5-dioxo-1,2,4-oxadiazolidin-2-yl)propanoic acid
- 1,2,4-Oxadiazolidine-2-propanoicacid, a-aMino-3,5-dioxo-, (aS)-
- ()-QUISQUALIC ACID
- 1,2,4-Oxadiazolidine-2-propanoic acid, α-amino-3,5-dioxo-, (αS)-
- (+)-QuisqualicAci
- QUISQUALIC ACID USP/EP/BP
- Quisqualinic acid
- Quisqualic acid (7CI)
- Quisqualic acid, group I mGlu agonist. AMPA agonist.
- Quisqualic acid (mM/ml), group I mGlu agonist
- 52809-07-1
- C5H7N3O5
- Amino Acids and Peptides
- Biochemicals and Reagents
- BioChemical
- Cell Signaling and Neuroscience
- Cell Biology
- Modified Amino Acids
- Ligand-Gated Ion Channels
- I - Z
- Ionotropic Glutamate Receptor Modulators
- Ion Channels
- Heterocycles
- Glutamate
- Amino Acids 13C, 2H, 15N
- Amino Acids & Derivatives
- Neurochemicals
- Glutamate receptor