PMPA(NAALADaseinhibitor)
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- CAS-Nr.
- 173039-10-6
- Englisch Name:
- PMPA(NAALADaseinhibitor)
- Synonyma:
- 2-PMPA;CS-2454;NAALADASEINHIBITOR;PMPA(NAALADaseinhibitor);2-PMPA(NAALADaseinhibitor);Pentanedioic acid, 2-(phosphonomethyl)-;2-(Phosphonomethyl)pentane-1,5-dioicacid;2-(PHOSPHONOMETHYL)PENTANEDIOIC ACID (PMPA);inhibit,Inhibitor,2PMPA,Carboxypeptidase,2-PMPA,2 PMPA
- CBNumber:
- CB91075110
- Summenformel:
- C6H11O7P
- Molgewicht:
- 226.12
- MOL-Datei:
- 173039-10-6.mol
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PMPA(NAALADaseinhibitor) Eigenschaften
- Siedepunkt:
- 538.8±60.0 °C(Predicted)
- Dichte
- 1.658±0.06 g/cm3(Predicted)
- storage temp.
- room temp
- L?slichkeit
- Soluble to 100 mM in sterile
- pka
- 2.06±0.10(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
- Wasserl?slichkeit
- Soluble to 100 mM in water
PMPA(NAALADaseinhibitor) Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
2-(Phosphonomethyl)pentanedioic Acid is a selective glutamate carboxypeptidase 2 (GCP-II) inhibitor, the enzyme which catabolizes the abundant neuropeptide N-acetyl-aspartyl-glutamate (NAAG) to N-acetylaspartate (NAA) and glutamate. A posiible target in the treatment of multiple sclerosis and Schizophrenia.
Biologische Aktivit?t
Highly potent and selective inhibitor of? glutamate carboxypeptidase 2 (GCP II/N-acetylated α -linked dipeptidase/NAALADase) with a K i value of 275 pM. Neuroprotective; protects against glutamate-mediated motor neuron degeneration and reduces volume of injury following middle cerebral artery occlusion (MCAO).
Biochem/physiol Actions
2-PMPA is a potent and selective inhibitor of Glutamate carboxypeptidase II (GCPII).
PMPA(NAALADaseinhibitor) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
PMPA(NAALADaseinhibitor) Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 79)Lieferanten
173039-10-6()Verwandte Suche:
- PMPA(NAALADaseinhibitor)
- 2-(Phosphonomethyl)pentane-1,5-dioicacid
- 2-PMPA
- CS-2454
- 2-PMPA(NAALADaseinhibitor)
- NAALADASEINHIBITOR
- Pentanedioic acid, 2-(phosphonomethyl)-
- 2-(PHOSPHONOMETHYL)PENTANEDIOIC ACID (PMPA)
- inhibit,Inhibitor,2PMPA,Carboxypeptidase,2-PMPA,2 PMPA
- 173039-10-6
