Propylphosphonic anhydride Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R61:Kann das Kind im Mutterleib sch?digen.
R20/21:Gesundheitssch?dlich beim Einatmen und bei Berührung mit der Haut.
R34:Verursacht Ver?tzungen.
R67:D?mpfe k?nnen Schl?frigkeit und Benommenheit verursachen.
R66:Wiederholter Kontakt kann zu spr?der oder rissiger Haut führen.
R11:Leichtentzündlich.

S-S?tze Betriebsanweisung:

S53:Exposition vermeiden - vor Gebrauch besondere Anweisungen einholen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36/37/39:Bei der Arbeit geeignete Schutzkleidung,Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S45:Bei Unfall oder Unwohlsein sofort Arzt zuziehen (wenn m?glich, dieses Etikett vorzeigen).
S33:Ma?nahmen gegen elektrostatische Aufladungen treffen.
S16:Von Zündquellen fernhalten - Nicht rauchen.

Chemische Eigenschaften

Clear light yellow solution

Verwenden

Propylphosphonic anhydride may be used in the following studies:

• As coupling agent for the synthesis of bispyridine-based ligands, which are used as bridging linkers in multinuclear platinum anticancer drugs.
• Microwave-assissted Fischer indolization of arylhydrazines.
• As acid activating agent for the direct synthesis of acid azides from carboxylic acids.
• One-pot synthesis of coumarins.
• Microwave-mediated synthesis of carbocyclic and heterocyclic fused quinolones.
• One-pot synthesis of 1,2,4-oxadiazoles, 1,3,4-oxadiazoles, and 1,3,4-thiadiazoles from carboxylic acids.
• Activation of the carboxyl group for hydroxyamidation and peptide coupling and in the one-pot conversion of carboxylic acids into hydroxamic acids.

Allgemeine Beschreibung

Propylphosphonic anhydride (T3P) is a reactive n-propyl phosphonic acid cyclic anhydride. It is a mild and low toxic coupling agent used in peptide synthesis. T3P also acts as a promoter and water scavenger in the Friedl?nder annulation reaction. It participates in the conversion of carboxylic acids and amides into nitriles, formation of Weinreb amides, ester synthesis, dehydrations, oxidation of alcohols, isonitrile synthesis, synthesis of alkenes from alcohols and C-C coupling reactions. T3P delivers outstanding advantages over traditional reagents, such as broad functional group tolerance, low epimerization, and water-soluble by-products and hence gives high purity and yield of the product.

Propylphosphonic anhydride Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

68957-94-8()Verwandte Suche:

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• 1-Propylphosphonic acid cyclic anhydride, 50+% w/w soln. in dichloroMethane
• 1-Propylphosphonic acid cyclic anhydride, 50 wt.% solution in ethyl acetate
• 1-Propylphosphonic anhydride solution, 50 wt. % in DMF
• 1-Propylphosphonic anhydride solution, 50 wt. % in ethyl acetate
• 2,4,6-tripropyl-1,3,5,2λ⁵,4λ⁵,6λ⁵-trioxatriphosphinane 2,4,6-trioxide
• 2,4,6-Tripropyl-1,3,5,2,4,6-trioxotriphosphorinane-2,4,6-trioxide (50% solution in Ethyl aceta
• 1-Propanephosphonic anhydride, in 50% DMF solution≥ 95%
• 2,4,6-Tripropyl-1,3,5,2,4,6-trioxatriphosphorinane-2,4,6-trioxide solution
• 2,4,6-TRIPROPYL-1,3,5,2,4,6-TRIOXATRIPHOSPHORINE-2,4,6-TRIOXIDE
• 2,4,6-Tripropyl-1,3,5-trioxa-2,4,6-triphosphacyclohexane 2,4,6-trioxide
• 2,4,6-Tripropyl-2,4,6-triphospha-1,3,5-trioxacyclohexane 2,4,6-trioxide
• 1,3,5,2,4,6-trioxatriphosphorinane
• 1-Propanephosphonic acid cyclic anhydride 50% ethyl acetate
• n-Propylphosphonic acid anhydride
• Propylphosphonic acid cyclic anhydride
• Propylphosphonic Anhydride Solution, 50% in Ethyl Acetate
• Propylphosphonic anhydride solution technical, ~50% in DMF
• 1-Propanephosphonic acid cyclic anhydride, 50 wt.% solution in dimethylformamide, AcroSeal
• 1-Propanephosphonic acid cyclic anhydride, 50 wt.% solution in ethyl acetate, AcroSeal
• propyl phoshonic anhydride
• t3p (50% solution in etoac)
• Propylphosphonic Anhydride Solution, 50wt.% in Ethyl Acetate
• 1-Propanephosphonic acid cyclic anhydride, 50 wt.% sol. in ethyl acetate 50ML
• 1-Propanephosphonic Acid Anhydride (Cyclic Trimer) 2,4,6-Tripropyl-1,3,5,2,4,6-trioxatriphosphorinane-2,4,6-trioxide
• 1,3,5,2,4,6-trioxatriphosphorinane,2,4,6-tripropyl-,2,4,6-trioxide
• propanephosphonicacidanhydride(t3p)
• propylphosphonicanhydridesolution
• PROPYLPHOSPHONIC ACID ANHYDRIDE CYCLIC TRIMER
• PROPYLPHOSPHONIC ANHYDRIDE
• TRIS-N-PROPAN-PHOSPHONIC ACID ANHYDRIDE
• Propylphosphonic anhydride solution technical,50% ethyl acetate
• 1-PROPANEPHOSPHONIC ACID ANHYDRIDE CYCLIC TRIMER
• 1-PROPYLPHOSPHONIC CYCLIC ANHYDRIDE
• 1-Propanephosphonic acid cyclic anhydride~(rgT3P~2,4,6-Tripropyl-2,4,6-trioxo-1,3,5,2,4,6-trioxatriphosphorinane
• 2,4,6-tripropyl-1,3,5-trioxa-2,4,6-triphosphorinane-2,4,6-trioxide
• Propanephosphonic acid cyclic anhydride (T3P)
• PROPYLPHOSPHONIC ANHYDRIDE SOLUTION, ~50 % IN DMF
• PROPANEPHOSPHONIC ANHYDRIDE 50 % IN ETH&
• 1-Propanephosphonic acid cyclic anhydride, 50 wt.% sol. in ethyl acetate
• 1-propanephosphonic anhydride solution
• 1-PROPYLPHOSPHONIC ACID CYCLIC ANHYDRIDE: 50% SOLUTION IN DMF
• TRIS-N-PROPAN-PHOSPHONIC ACID ANHYDRIDE: (50% IN DMF)
• Propylphosphonic Acid Anhydride (Cyclic Trimer) (48% in N,N-Dimethylformamide, ca. 1.6mol/L)
• Propylphosphonic Acid Anhydride (Cyclic Trimer) (50% in Ethyl Acetate, ca. 1.7mol/L)
• tripropyl-1,3,5,2λ,4λ,6λ-trioxatriphosphinane-2,4,6-trione
• 1-Propylphosphonic acid cyclic anhydride, 50+% soln. in DMF
• 2,4,6-tri-n-propyl-2,4,6-trioxo-1,3,5,2,4,6-trioxatriphosphorinane
• 1-Propanephosphonic anhydride solution, 2,4,6-Tripropyl-1,3,5,2,4,6-trioxatriphosphorinane-2,4,6-trioxide solution
• 1-Propanephosphonic acid cyclic anhydride, 50 WT.% solution in dimethylformamide
• 1-PROPANEPHOSPHONIC ACID CYCLIC ANHYDRID E, 50 WT. % SOLUTION IN ETHYL ACETATE
• PROPYLPHOSPHONIC ANHYDRIDE SOLUTION, ~50 % IN ETHYL ACET.
• 1-Propylphosphonicacidcyclicanhydride,50+%soln.inethylacetate
• Propylphosphonic anhydride solution (50 wt.% in DMF)
• 4-[(R)-3-aminopiperidin-1-yl]-2-({6-[(R)-3-aminopiperidin-1-yl]-3-methyl-2,4-dioxo-1,2,3,6-tetrahydropyrimidin-1-yl}methyl)benzonitrile, 4-((R)-3-aminopiperidin-1-yl)-2-((6-((R)-3-aminopiperidin-1-yl)-3-methyl-2,4-oxo-3,4-dihydropyrimidin-1(2H)-yl)methyl)benzonitrile
• Propylphosphonic anhydride 50% in EA
• Propylphosphonic anhydride 50% in DMF
• 2,4,6-Tri-n-propyl-2,4,6-trioxo-1,3,5,2,4,6-trioxatriphosphorinane (Propylphosphonic acid anhydride 50% solution in N,N-dimethylformamide) T3P
• 2,4,6-Tripropyl-2,4,6-trioxo-1,3,5,2,4,6-trioxatriphosphorinane T3P (Propylphosphonic acid anhydride 50% solution in ethyl acetate)