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4-(2-(3,5-Dihydroxyphenyl)-ethenyl)-1,2-benzoldiol

PICEATANNOL Struktur
10083-24-6
CAS-Nr.
10083-24-6
Bezeichnung:
4-(2-(3,5-Dihydroxyphenyl)-ethenyl)-1,2-benzoldiol
Englisch Name:
PICEATANNOL
Synonyma:
Piceatanl;NSC-622471;PICEATANNOL;Astringenin;Beryl alcohol;20MG/50MG/100G;Piceatannol>Piceatannol(P);Piceatannol,96%;(E)-Piceatannol
CBNumber:
CB8377487
Summenformel:
C14H12O4
Molgewicht:
244.24
MOL-Datei:
10083-24-6.mol

4-(2-(3,5-Dihydroxyphenyl)-ethenyl)-1,2-benzoldiol Eigenschaften

Schmelzpunkt:
223.0-227.0 °C
Siedepunkt:
108°C/0.04mmHg(lit.)
Dichte
1.1245 (rough estimate)
Brechungsindex
1.5190 (estimate)
storage temp. 
2-8°C
L?slichkeit
H2O: 0.5 mg/mL
Aggregatzustand
powder
pka
9.17±0.10(Predicted)
Farbe
light tan to yellow
maximale Wellenl?nge (λmax)
323nm(MeOH)(lit.)
Stabilit?t:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
LogP
2.690 (est)

Sicherheit

S-S?tze: 24/25
WGK Germany  3
HS Code  29072990

4-(2-(3,5-Dihydroxyphenyl)-ethenyl)-1,2-benzoldiol Chemische Eigenschaften,Einsatz,Produktion Methoden

S-S?tze Betriebsanweisung:

S24/25:Berührung mit den Augen und der Haut vermeiden.

Chemische Eigenschaften

yellow to golden or green crystalline powder

Verwenden

A human metabolite of Resveratrol (R150000). Piceatannol is strong anti-oxidant.

Definition

ChEBI: A stilbenol that is trans-stilbene in which one of the phenyl groups is substituted by hydroxy groups at positions 3 and 4, while the other phenyl group is substituted by hydroxy groups at positions 3 and 5.

Allgemeine Beschreibung

A cell-permeable, substrate competitive and reversible plant metabolite that inhibits the activity of rat liver protein kinase A catalytic subunit (IC50 = 3 μM), PKC (IC50 = 8 μM), MLCK (IC50 = 12 μM). In RBL-2H3 cells, the selective inhibition of Syk by piceatannol results in inhibition of FceR1-mediated signaling. Also inhibits wheat embryo Ca2+-dependent protein kinase (CDPK) (IC50 = 19 μM), and p72syk (IC50 = 10 μM), a non-receptor tyrosine kinase, relative to Lyn in isolated enzyme preparations. Also possesses anti-leukemic properties. Reported to activate sirtuins and promote the survival of eukaryotic cells.

Biologische Aktivit?t

Anti-inflammatory, immunomodulatory and antiproliferative agent. Inhibits p56 lck and syk protein tyrosine kinases and inhibits TNF-induced NF- κ B activation and gene expression. Synthesis results from conversion of resveratrol (5-[(1E)-2-(4-Hydroxyphenyl)ethenyl]-1,3,benzenediol ) by cytochrome P450 1B1.

4-(2-(3,5-Dihydroxyphenyl)-ethenyl)-1,2-benzoldiol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


4-(2-(3,5-Dihydroxyphenyl)-ethenyl)-1,2-benzoldiol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 377)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Weibang Biotechnology Co., Ltd
+8615531157085
abby@weibangbio.com China 8806 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-81148696 +86-15536356810
1022@dideu.com China 3882 58
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
+86-029-86333380 18829239519
sales06@tgybio.com China 901 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5889 58
Hebei Kingfiner Technology Development Co.Ltd
+86-15532196582 +86-15373005021
lisa@kingfinertech.com China 3007 58
Henan Fengda Chemical Co., Ltd
+86-371-86557731 +86-13613820652
info@fdachem.com China 20271 58
BINBO BIOLOGICAL CO.,LTD
+8618629063126
info@binbobiological.com China 430 58
Hebei Zhuanglai Chemical Trading Co Ltd
+86-16264648883 +86-16264648883
niki@zlchemi.com China 3001 58
Shanghai Daken Advanced Materials Co.,Ltd
+86-371-66670886
info@dakenam.com China 18945 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21634 55

10083-24-6(4-(2-(3,5-Dihydroxyphenyl)-ethenyl)-1,2-benzoldiol)Verwandte Suche:


  • TRANS-3,3',4,5'-TETRAHYDROXYSTILBENE
  • PICEATANNOL
  • PICEATANNOL (3,3',4,5'-TETRAHYDROXY-TRAN
  • (e)-4-[2-(3,5dihydroxyphenyl)ethenyl]1,2-benzenediol
  • 4-[2-(3,5-dihydroxyphenyl)ethenyl]benzene-1,2-diol
  • trans-Piceatannol
  • (E)-3,3',4,5'-Tetrahydroxystilbene
  • (E)-Piceatannol
  • Astringenin
  • Piceatannol,96%
  • Piceatannol3,4,3',5'-Tetrahydroxy-trans-stilbene
  • Piceatanl
  • 5-[(E)-2-(3,4-dihydroxyphenyl)ethenyl]benzene-1,3-diol
  • 20MG/50MG/100G
  • (E)-4-(3,5-dihydroxystyryl)benzene-1,2-diol
  • (E)-3,3',4,5'-Stilbenetetrol
  • 4-[(1E)-2-(3,5-DIHYDROXYPHENYL)ETHENYL]-1,2-BENZENEDIOL
  • 3,3',4,5'-TETRAHYDROXYSTILBENE
  • 3,3',4,5'-TETRAHYDROXY-TRANS-STILBENE
  • 3,4,3',5'-TETRAHYDROXY-TRANS-STILBENE
  • Piceatannol, (E)-
  • Piceatannol - CAS 10083-24-6 - Calbiochem
  • 1,2-Benzenediol,4-[(1E)-2-(3,5-dihydroxyphenyl)ethenyl]-
  • Piceatannol>
  • Piceatannol ,>98%
  • Resveratrol 3-Hydroxy Impurity
  • Resveratrol Impurity 20 (trans-Piceatannol)
  • NSC-622471
  • Piceatannol (Astringenin
  • Beryl alcohol
  • Piceatannol (6CI)
  • trans-Piceatannol|||Astringenin
  • Piceatannol(P)
  • trans-Piceatannol-RM
  • Piceatannol, Syk tyrosine kinase inhibitor
  • 10083-24-6
  • Cell Signaling and Neuroscience
  • BioChemical
  • Lymphocyte Specific Kinase and Spleen Tyrosine Kinase (Lck, Syk)
  • Kinase/Phosphatase Biology
  • Non-Receptor Tyrosine Kinase Inhibitors
  • Cell Biology
  • Aromatics
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • chemical reagent
  • pharmaceutical intermediate
  • Protein Kinase
  • Stilbenes (substituted)
  • Aromatics, Metabolites & Impurities, Pharmaceuticals, Intermediates & Fine Chemicals
  • Inhibitors
  • Syk
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
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