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IVACHTIN

IVACHTIN Struktur
745046-84-8
CAS-Nr.
745046-84-8
Englisch Name:
IVACHTIN
Synonyma:
IVACHTIN;2-(4-methyl-8-morpholin-4-ylsulfonyl-1,3-dioxopyrrolo[3,4-c]quinolin-2-yl)ethyl acetate;1H-Pyrrolo[3,4-c]quinoline-1,3(2H)-dione, 2-[2-(acetyloxy)ethyl]-4-methyl-8-(4-morpholinylsulfonyl)-;2-(4-Methyl-8-(morpholinosulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl)ethyl acetate;2-[4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl]ethylacetate;modest,reversibl,Inhibitor,noncompetitive,Caspase,caspases,nonpeptide,inhibit,apoptosis,Ivachtin,selectivity,staurosporininduced
CBNumber:
CB82459565
Summenformel:
C20H21N3O7S
Molgewicht:
447.46
MOL-Datei:
745046-84-8.mol

IVACHTIN Eigenschaften

Siedepunkt:
665.0±65.0 °C(Predicted)
Dichte
1.459±0.06 g/cm3(Predicted)
storage temp. 
Desiccate at +4°C
L?slichkeit
Limited solubility, soluble in DMSO or DMF
pka
1.87±0.20(Predicted)
Aggregatzustand
Off-white solid
Farbe
off-white

Sicherheit

IVACHTIN Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Ivachtin is a potent, cell-permeable, reversible, non-competitive inhibitor of caspase-3.

Allgemeine Beschreibung

A cell-permeable, non-peptidyl pyrroloquinoline compound that acts as a potent, reversible, and non-competitive inhibitor of caspase-3 (IC50 = 23 nM) with larger than 10-fold greater selectivity towards caspase-3 than caspases-1, -2, and -4 through -10. Shown to display higher anti-apoptotic activity than Z-VAD-FMK (Cat. No. 627610) in preventing Staurosporine- (Cat. No. 569397) induced apoptosis in human Jurkat T cells.

Biochem/physiol Actions

Cell permeable: yes

IVACHTIN Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

IVACHTIN Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 58)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Hefei Hirisun Pharmatech Co., Ltd 		+8615056975894
 shawn@hirisunpharm.com CHINA 9911 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15839 69
VDM Biochemicals 0330-2528181
sales@vdmbio.com United States 510 64
BOC Sciences 1-631-485-4226; 16314854226
 info@bocsci.com United States 14055 65
AdooQ BioScience, LLC +1 (866) 930-6790
info@adooq.com United States 2782 58
EMMX Biotechnology LLC 888-539-0666
info@emmx.com United States 8447 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9806 58
Beijing Jin Ming Biotechnology Co., Ltd. 010-60605840 18892239720
 psaitong@jm-bio.com China 12306 58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd 0571-85361029
synstar518@163.com China 1990 58
  • IVACHTIN
  • 2-[4-Methyl-8-(morpholin-4-ylsulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl]ethylacetate
  • 2-(4-methyl-8-morpholin-4-ylsulfonyl-1,3-dioxopyrrolo[3,4-c]quinolin-2-yl)ethyl acetate
  • modest,reversibl,Inhibitor,noncompetitive,Caspase,caspases,nonpeptide,inhibit,apoptosis,Ivachtin,selectivity,staurosporininduced
  • 1H-Pyrrolo[3,4-c]quinoline-1,3(2H)-dione, 2-[2-(acetyloxy)ethyl]-4-methyl-8-(4-morpholinylsulfonyl)-
  • 2-(4-Methyl-8-(morpholinosulfonyl)-1,3-dioxo-1,3-dihydro-2H-pyrrolo[3,4-c]quinolin-2-yl)ethyl acetate
  • 745046-84-8
  • Inhibitor of caspase-3.
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