Aripiprazole
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- CAS-Nr.
- 129722-12-9
- Englisch Name:
- Aripiprazole
- Synonyma:
- ABILIFY;ARIPIPRAZOLE-D8;Arpiprazole;Aripirazole;OPC 31;ABILITAT;OPC 14597;Abilify-d8;OPC 31-d8-;Abilitat-d8
- CBNumber:
- CB8210870
- Summenformel:
- C23H27Cl2N3O2
- Molgewicht:
- 448.39
- MOL-Datei:
- 129722-12-9.mol
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Aripiprazole Eigenschaften
- Schmelzpunkt:
- 139°C
- Siedepunkt:
- 646.2±55.0 °C(Predicted)
- Dichte
- 1.263±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: soluble5mg/mL, clear (warmed)
- pka
- 14.42±0.20(Predicted)
- Aggregatzustand
- powder
- Farbe
- white to beige
- Merck
- 14,785
- BCS Class
- 2
- Stabilit?t:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
- InChI
- InChI=1S/C23H27Cl2N3O2/c24-19-4-3-5-21(23(19)25)28-13-11-27(12-14-28)10-1-2-15-30-18-8-6-17-7-9-22(29)26-20(17)16-18/h3-6,8,16H,1-2,7,9-15H2,(H,26,29)
- InChIKey
- CEUORZQYGODEFX-UHFFFAOYSA-N
- SMILES
- N1C2=C(C=CC(OCCCCN3CCN(C4=CC=CC(Cl)=C4Cl)CC3)=C2)CCC1=O
- CAS Datenbank
- 129722-12-9(CAS DataBase Reference)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
  
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H225 |
Flüssigkeit und Dampf leicht entzündbar. |
Entzündbare Flüssigkeiten |
Kategorie 2 |
Achtung |
![GHS hazard pictograms]() src="/GHS02.jpg" width="20" height="20" /> |
P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501 |
| H370 |
Sch?digt die Organe. |
Spezifische Zielorgan-Toxizit?t (einmalige Exposition) |
Kategorie 1 |
Achtung |
![GHS hazard pictograms]() src="/GHS08.jpg" width="20" height="20" /> |
P260, P264, P270, P307+P311, P321,P405, P501 |
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| Sicherheit |
| P210 |
Von Hitze, hei?en Oberfl?chen, Funken, offenen Flammen und anderen Zündquellenarten fernhalten. Nicht rauchen. |
| P233 |
Beh?lter dicht verschlossen halten. |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
| P303+P361+P353 |
BEI BERüHRUNG MIT DER HAUT (oder dem Haar): Alle kontaminierten Kleidungsstücke sofort ausziehen. Haut mit Wasser abwaschen oder duschen. |
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Aripiprazole Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Colourless Flake Crystalline Solid
Verwenden
A deuterated version of Aripiprazole, a selective dopamine D2-receptor antagonist with dopamine autoreceptor agonist activity.
Please note that users have reported separation of this compound and aripiprazole under normal-phase and reverse-phase
Allgemeine Beschreibung
Aripiprazole (Abilify). The newest, longactingaripiprazole (an arylpiperazine quinolinone derivative),appears to be partial agonist of D
2 receptors (i.e., itstimulates certain D2 receptors while blocking others dependingon their locations in the brain and the concentrationof drug). Bioavailability of aripiprazole is around 87%, with peak plasma concentration attained at 3 to 5 hours afterdosing. It is metabolized by dehydrogenation, oxidative hydroxylation, and N-dealkylation, largelymediated by hepatic CYPs 3A4 and 2D6.
The diphenylbutylpiperidine class can be considered amodification of the fluorobutyrophenone class. Because oftheir high lipophilicity, the compounds are inherently longacting. Pimozide has been approved for antipsychotic use,and penfluridol has undergone clinical trials in the UnitedStates. Overall, side effects for the two compounds resemblethose produced by the fluorobutyrophenones.
Hazard
A poison.
Sicherheitsprofil
A poison by intravenous route.When heated to decomposition it emits toxic vapors ofNOx and Cl
-.
Aripiprazole Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Aripiprazole Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 673)Lieferanten
129722-12-9()Verwandte Suche:
- ARIPIPRAZOLE
- ABILITAT
- 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydrocarbostyril
- OPC 14597
- OPC 31
- 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-2(1H)-quinolinone
- OPC-14597, OPC-31,
- 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydro-1H-quinolin-2-one
- Form I of Aripiprazole
- Aripiprazole solution
- Aripiprazole (200 mg)
- Aripiprazole, >=99%
- Alipiprazole
- 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl-d8]butoxy]-3,4-dihydro-2(1H)-quinolinone
- 7-[4-[4-(2,3-Dichlorophenyl)-1-piperazinyl-d8]butoxy]-3,4-dihydrocarbostyril
- Abilify-d8
- Abilitat-d8
- OPC 14597-d8
- OPC 31-d8-
- 7-[4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy]-3,4-dihydrocarbostyril
- 2(1H)-Quinolinone, 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydro-
- 7-{4-[4-(2,3-Dichlorophenyl)piperazin-1-yl]butoxy}-3,4-dihydroquinolin-2(1H)-one
- Aripiprozole
- Aripiprazole (Abilify)
- Aripiprazole Tablets
- Aripiprazole (Both tablet and inj grade)
- 7-{4-[4-(2,3-dichlorophenyl)piperazin-1-yl]butoxy}-1,2,3,4-tetrahydroquinolin-2-one
- Crystal forms reference substance of Aripiprazole
- Form II of Aripiprazole
- Form C of Aripiprazole
- Form B of Aripiprazole
- Aripiprazole Form I
- Aripiprazole Form II
- Aripiprazole Form A
- Aripiprazole Form B
- Aripiprazole Form C
- Aripiprazole Form D
- Aripiprazole Form E
- Aripiprazole Form F
- Aripiprazole Form G
- Aripiprazole, 98%, a human 5-HT1A receptor partial agonist
- Aripiprazole Manufacturer
- Aripiprazole >
- Aripiprazole CRS
- Aripiprazole USP/EP/BP
- Aripiprazole (OPC-14597)
- AripiprazoleQ: What is
Aripiprazole Q: What is the CAS Number of
Aripiprazole Q: What is the storage condition of
Aripiprazole Q: What are the applications of
Aripiprazole
- TIANFU-CHEM CAS:129722-12-9 Aripiprazole
- Aripiprazole (1042634)
- ARIPIPRAZOLE-D8
- ABILIFY
- Arpiprazole
- Aripirazole
- Aripiprazole Type 1
- Aripirazole (USP)
- Aripiprazole
7-(4-(4-(2,3-dichlorophenyl)piperazin-1-yl)butoxy)-3,4- dihydroquinolin-2(1H)-one
- 7-[4-[4-(2,3-dichlorophenyl)-1-piperazinyl]butoxy]-3,4-dihydrChemicalbookocarbostyril
- Aripiprazole in acetonitrile
