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SR 11302

SR 11302 Struktur
160162-42-5
CAS-Nr.
160162-42-5
Englisch Name:
SR 11302
Synonyma:
SR 11302;SR 11302, 10 mM in DMSO;RQANARBNMTXCDM-DKOHIBGUSA-N;(2E,4E,6Z,8E)-3-Methyl-7-(p-tolyl)-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid;(E,E,Z,E)-3-Methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoicacid;2,4,6,8-Nonatetraenoic acid, 3-methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (2E,4E,6Z,8E)-;acid,SR11302,retinoid,SR-11302,Lung,RARE,Cancer,response,Inhibitor,protein-1,SR 11302,inhibit,AP-1,retinoic,element,activator
CBNumber:
CB7844692
Summenformel:
C26H32O2
Molgewicht:
376.53
MOL-Datei:
160162-42-5.mol

SR 11302 Eigenschaften

Siedepunkt:
541.6±30.0 °C(Predicted)
Dichte
1.048±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
L?slichkeit
Soluble in DMSO
Aggregatzustand
crystalline solid
pka
4.67±0.33(Predicted)
Farbe
Light yellow to yellow

Sicherheit

SR 11302 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The receptors for retinoids, RARs and RXRs, induce transcriptional activation by binding the specific retinoid response elements, RARE and RXRE. Alternatively, retinoid receptors interact with and modulate other transcription factors, including activator protein-1 (AP-1). SR 11302 is a synthetic retinoid that inhibits AP-1 activity without activating transcription through RARE. It significantly suppresses both AP-1 activation and phorbol ester-induced papilloma formation in mice when applied topically (0.1 μM). SR 11302 is used to elucidate the role of AP-1 in various signaling pathways.

Verwenden

SR 11302 is an inhibitor of activator protein-1.

Biologische Aktivit?t

Inhibitor of activator protein-1 (AP-1) transcription factor activity that displays antitumor effects in vivo . Does not activate transcription from the retinoic acid response element (RARE) and displays no activity at retinoic acid receptors (EC 50 > 1 μ M for RAR α , RAR β , RAR γ and RXR α ).

SR 11302 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

SR 11302 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 72)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Aromsyn Co., Ltd. 		+86-0571-85585865 +8613336024896
 CB@aromsyn.com China 19183 58
Shenyang Zhongshen Zekang Biomedical Technology Research Co., Ltd 		+86-18341751992 +86-15382112998
 757984502@qq.com China 892 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
Wuhan Jingkang en Biomedical Technology Co., Ltd 		+8613720134139
 orders@jknbiochem.com China 5221 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131957 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15839 69
ShangHai Caerulum Pharma Discovery Co., Ltd. 18149758185 18149758185
 sales-cpd@caerulumpharma.com China 3466 58
EMMX Biotechnology LLC 888-539-0666
info@emmx.com United States 8447 60
Pharmacodia (Beijing) Co.,Ltd +86-400-851-9921
sales@pharmacodia.com China 2317 55

160162-42-5()Verwandte Suche:

  • SR 11302
  • (E,E,Z,E)-3-Methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-2,4,6,8-nonatetraenoicacid
  • RQANARBNMTXCDM-DKOHIBGUSA-N
  • 2,4,6,8-Nonatetraenoic acid, 3-methyl-7-(4-methylphenyl)-9-(2,6,6-trimethyl-1-cyclohexen-1-yl)-, (2E,4E,6Z,8E)-
  • (2E,4E,6Z,8E)-3-Methyl-7-(p-tolyl)-9-(2,6,6-trimethylcyclohex-1-en-1-yl)nona-2,4,6,8-tetraenoic acid
  • acid,SR11302,retinoid,SR-11302,Lung,RARE,Cancer,response,Inhibitor,protein-1,SR 11302,inhibit,AP-1,retinoic,element,activator
  • SR 11302, 10 mM in DMSO
  • 160162-42-5
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