Biperiden
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- CAS-Nr.
- 514-65-8
- Bezeichnung:
- Biperiden
- Englisch Name:
- Bipariden
- Synonyma:
- kl373;KL 373;Akineton;biperiden;Beperiden;bipariden;Akinophyl;Bibristan;Biperidine;BiperidenHcl
- CBNumber:
- CB7501632
- Summenformel:
- C21H29NO
- Molgewicht:
- 311.46106
- MOL-Datei:
- 514-65-8.mol
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Biperiden Eigenschaften
- Schmelzpunkt:
- 114°C
- Siedepunkt:
- 451.49°C (rough estimate)
- Dichte
- 1.0202 (rough estimate)
- Brechungsindex
- 1.5614 (estimate)
- storage temp.
- 2-8°C
- L?slichkeit
- Chloroform (Slightly), DMSO (Slightly,Sonicated), Methanol (Slightly, Sonicated)
- Aggregatzustand
- Solid
- pka
- 14.05±0.29(Predicted)
- Farbe
- White to Off-White
- Wasserl?slichkeit
- 25.1 mg/L
- NIST chemische Informationen
- Biperiden(514-65-8)
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Bildanzeige (GHS) |
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| Alarmwort |
Warnung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H302 |
Gesundheitssch?dlich bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 4 |
Warnung |
![GHS hazard pictograms]() src="/GHS07.jpg" width="20" height="20" /> |
P264, P270, P301+P312, P330, P501 |
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| Sicherheit |
| P280 |
Schutzhandschuhe/Schutzkleidung/Augenschutz tragen. |
| P305+P351+P338 |
BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen. |
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Biperiden Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
amoebicide
Definition
ChEBI: N-Propylpiperidine in which the methyl hydrogens are substituted by hydroxy, phenyl, and 5-norbornen-2-yl groups. A muscarinic antagonist affecting both the central and peripheral nervous systems, it is used in the treatment of all form
of Parkinson's disease.
Allgemeine Beschreibung
Biperiden,α-5-norbornen-2-yl- -phenyl-1-piperidinepropanol (Akineton), introduced in 1959,has a relatively weak visceral anticholinergic, but a strongnicotinolytic, action in terms of its ability to block nicotineinducedconvulsions. Therefore, its neurotropic action israther low on intestinal musculature and blood vessels. It hasa relatively strong musculotropic action, which is aboutequal to that of papaverine, in comparison with most syntheticanticholinergic drugs. Its action on the eye, althoughmydriatic, is much lower than that of atropine. These weakanticholinergic effects add to its usefulness in Parkinson syndromeby minimizing side effects.
Clinical Use
Biperiden is used in all types of Parkinson disease (postencephalitic,idiopathic, arteriosclerotic) and helps toeliminate akinesia, rigidity, and tremor. It is also usedin drug-induced extrapyramidal disorders to eliminatesymptoms and permit continued use of tranquilizers.Biperiden is also of value in spastic disorders not related toparkinsonism, such as multiple sclerosis, spinal cord injury,and cerebral palsy. It is contraindicated in all formsof epilepsy.
Sicherheitsprofil
Poison by ingestion,subcutaneous, intraperitoneal, and intravenous routes.When heated to decomposition, it emits toxic fumes ofNOx.
Biperiden Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Biperiden Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 103)Lieferanten
514-65-8(Biperiden)Verwandte Suche:
gamma-(4-(p-Chlorphenyl)4-hydroxy-piperidino)-p-fluorbutyrophenon
2,2,6,6-Tetramethylpiperidin-4-ol
Droperidol
3a,4,7,7a-Tetrahydro-4,7-methan-1H-inden
2,2,6,6-Tetramethyl-4-piperidylamin
Diphenoxylat
alpha-Bicyclo(2.2.1)hept-5-en-2-yl-alphaphenyl)-1-piperidin-propanol-hydrochlorid
Piperidin-1-propanol
Cyclohepten
Bicyclo[2.2.1]hept-5-en-2-methanol
Milchsure, Verbindung mit α-Bicyclo[2.2.1]hept-5-en-2-yl-α-phenylpiperidin-1-propanol (1:1)
Cycrimin
Biperiden
- alpha-(bicyclo(2.2.1)hept-5-en-2-yl)-alpha-phenyl-1-piperidinopropanol
- alpha-5-norbornen-2-yl-alpha-phenyl-1-piperidinepropano
- alpha-5-Norbornen-2-yl-alpha-phenyl-1-piperidinepropanol
- alpha-bicyclo(2.2.1)hept-5-en-2-yl-alpha-phenyl-1-piperidinepropano
- alpha-phenyl-alpha-(2-piperidinoethyl)-5-norbornene-2-methano
- Beperiden
- -Bicyclo[2,2,1]hept-5-en-2yl-phenyl-1-piperidinepropanol
- Bicyclo[2.2.1]hept-5-ene-2-methanol, alpha-phenyl-alpha-[2-(1-piperidinyl)ethyl]-
- biperiden
- Biperidine
- KL 373
- BIPERIDEN (200 MG)
- 1-(5-bicyclo[2.2.1]hept-2-enyl)-1-phenyl-3-(1-piperidyl)propan-1-ol
- 1-Bicyclo[2.2.1]hept-5-en-2-yl-1-phenyl-3-(1-piperidinyl)-1-propanol
- 1-Bicycloheptenyl-1-phenyl-3-piperidino-propanol-1
- 1-Piperidinepropanol, alpha-5-norbornen-2-yl-alpha-phenyl-
- 1-Piperidinepropanol, alpha-bicyclo[2.2.1]hept-5-en-2-yl-alpha-phenyl-
- 3-Piperidino-1-phenyl-1-bicyclo-
- 3-Piperidino-1-phenyl-1-bicyclo(2.2.1)hepten-(5)-yl-propanol-(1)
- 3-Piperidino-1-phenyl-1-bicycloheptenyl-1-propanol
- bipariden
- -5-Norbornen-2-yl-phenyl-1-piperidinepropanol
- 5-Norbornene-2-methanol, alpha-phenyl-alpha-(2-piperidinoethyl)-
- a-bicyclo[2.2.1]hept-5-en-2yl-a-phenyl-1-piperidinepropanol
- Akineton
- Akinophyl
- alpha-(Bicyclo(2.2.1)hept-5-en-2-yl)-alpha-phenyl-1-piperidino propanol
- kl373
- 1-phenyl-3-piperidino-1-(8,9,10-trinorborn-5-en-2-yl)propan-1-ol
- BiperidenHcl
- 1-Piperidinepropanol, a-5-norbornen-2-yl-a-phenyl- (6CI, 7CI, 8CI)
- 1-Piperidinepropanol, a-bicyclo[2.2.1]hept-5-en-2-yl-a-phenyl-
- α-(Bicyclo[2.2.1]hept-5-en-2-yl)-α-phenyl-1-piperidinopropanol
- α-(Bicyclo[2.2.1]hept-5-en-2-yl)-α-phenyl-1-piperidine-1-propanol
- Biperiden, USP
- Biperiden Hydrochloride USP
- Biperiden (Mixture of diastereomers)
- Bibristan
- 1-Piperidinepropanol, α-bicyclo[2.2.1]hept-5-en-2-yl-α-phenyl-
- Bipariden USP/EP/BP
- Alpha-5-Norbornene-2-yl-alphaphentl-1-piperidinepropanol (Biperiden base)
- Biperiden Hcl -USP/ EP/IP/JP
- Biperiden (1072001)
- 1-(Bicyclo[2.2.1]hept-5-en-2-yl)-1-phenyl-3-(piperidin-1-yl)propan-1-ol
- Bipariden Impurity
- 514-65-8
- C21H29NO
