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Betamethason

Betamethasone Struktur
378-44-9
CAS-Nr.
378-44-9
Bezeichnung:
Betamethason
Englisch Name:
Betamethasone
Synonyma:
Betamethason;C22H29O5F;Betametasone;betamethasone standard;Dermabet;Celestone;FLUBENISOLONE;17,21-trihydr;Dexamethasone EP Impurity B;Bifas
CBNumber:
CB7392335
Summenformel:
C22H29FO5
Molgewicht:
392.47
MOL-Datei:
378-44-9.mol

Betamethason Eigenschaften

Schmelzpunkt:
235-237°C
alpha 
D +108° (acetone)
Siedepunkt:
568.2±50.0 °C(Predicted)
Dichte
1.1283 (estimate)
Brechungsindex
118 ° (C=1, Dioxane)
storage temp. 
0-6°C
L?slichkeit
Practically insoluble in water, sparingly soluble in anhydrous ethanol, very slightly soluble in methylene chloride.
Aggregatzustand
Solid
pka
12.13±0.70(Predicted)
Farbe
White to Off-White
Biologische Quelle
synthetic (organic)
Wasserl?slichkeit
58mg/L(25 ºC)
Merck 
14,1180
LogP
2.01 at 25℃
CAS Datenbank
378-44-9(CAS DataBase Reference)
NIST chemische Informationen
Pregna-1,4-diene-3,20-dione, 9alpha-fluoro-11beta,17alpha,21-trihydroxy-16beta-methyl-(378-44-9)
EPA chemische Informationen
Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11.beta.,16.beta.)- (378-44-9)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xi,Xn,T
R-S?tze: 40-48/20/21-61
S-S?tze: 22-36-45-53
WGK Germany  2
RTECS-Nr. TU4000000
HS Code  29379000
Giftige Stoffe Daten 378-44-9(Hazardous Substances Data)
Toxizit?t LD50 oral in mouse: > 4500mg/kg
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H373 Kann die Organe sch?digen bei l?ngerer oder wiederholter Exposition. Spezifische Zielorgan-Toxizit?t (wiederholte Exposition) Kategorie 2 Warnung P260, P314, P501
Sicherheit
P202 Vor Gebrauch alle Sicherheitshinweise lesen und verstehen.
P260 Dampf/Aerosol/Nebel nicht einatmen.
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P308+P313 BEI Exposition oder falls betroffen: ?rztlichen Rat einholen/?rztliche Hilfe hinzuziehen.
P405 Unter Verschluss aufbewahren.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Betamethason Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R40:Verdacht auf krebserzeugende Wirkung.

S-S?tze Betriebsanweisung:

S22:Staub nicht einatmen.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.

Beschreibung

Shortly after the introduction of dexamethasone, betamethasone, which differs from dexamethasone only in configuration of the 16-methyl group, was made available for the treatment of rheumatic diseases and dermatologic disorders. This analogue, which contains a 16β-methyl group, has received sufficient clinical trial examination to indicate that it is as effective as dexamethasone or, perhaps, even slightly more active. Although this drug has been reported to be less toxic than other steroids, some clinical investigators suggest that it is best used for short-term therapy.

Chemische Eigenschaften

White to Off-White Solid

Verwenden

Betamethasone is a glucocorticoid used as an anti-inflammatory agent.

Allgemeine Beschreibung

Betamethasone, 9-fluoro-11β,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione,is available as a variety of ester derivatives.
Betamethasone valerate, USP (17-valerate)
Betamethasone acetate, USP (21-acetate)
Betamethasone sodium phosphate, USP (21-sodiumphosphate)
Betamethasone dipropionate, USP (17-propionate,21-propionate).

Nebenwirkungen

Toxic side effects, such as increased appetite, weight gain, and facial mooning, occur with prolonged use.

Sicherheitsprofil

Low toxicity by ingestion. Anexperimental teratogen. Other experimental reproductiveeffects. When heated to decomposition it emits toxicfumes of F-.

l?uterung methode

Betamethasone crystallises from ethyl acetate, and has max at 238nm (log 4.18) in MeOH. The 21-acetate [287-24-6] crystallises from Me2CO/Et2O (charcoal) m 196-201o (205-208o) and has [] D 20 +140o (CHCl3). [Taub et al. J Am Chem Soc 82 4012 1960, Olivetto et al. J Am Chem Soc 80 6688 1958, Beilstein 8 IV 3501.]

Betamethason Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Betamethason Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 700)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TOKYO CHEMICAL INDUSTRY CO., LTD.
03-36680489
Sales-JP@TCIchemicals.com Japan 28387 80
CHONGQING CHENCHENG PHARMACEUTICAL CO.,LTD.
15923947264
lf19823605252@163.com China 107 58
Hebei Chuanghai Biotechnology Co., Ltd
+86-15531157085 +86-15531157085
abby@chuanghaibio.com China 8807 58
Shaanxi Dideu Medichem Co. Ltd
+86-29-81148696 +86-15536356810
1022@dideu.com China 3882 58
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5878 58
Hebei Anlijie Biotechnology Co., Ltd
+8619031013551
ably@aljbio.com China 144 58
Hebei Kangcang new material Technology Co., LTD
+8615713292910
Nancy@kangcang.com.cn China 341 58
Shandong Xuhuang New material CoLTD
+86-15095020839 +86-17660422208
sales01@xh-plastic.cn China 726 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21631 55
Hubei XinRunde Chemical Co., Ltd.
+8615102730682
bruce@xrdchem.cn CHINA 566 55

378-44-9(Betamethason)Verwandte Suche:


  • Betamethasone valerate impurity A (PhEur)
  • Betamethasone solution,100ppm
  • (8S,10S,11S,13S,14S,16S,17R)-9-fluoro-11-hydroxy-10,13,16-trimethyl-3-oxo-17-(2-(propionyloxy)acetyl)-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-17-yl propionate
  • BETAMETHASONE
  • BETADEXAMETHASONE
  • (11beta,16beta)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
  • 16-beta-methyl-1,4-pregnadiene-9-alpha-fluoro-11-beta,17-alpha,21-triol-3,20
  • 16-beta-Methyl-1,4-pregnadiene-9-alpha-fluoro-11-beta,17-alpha,21-triol-3,20-dione
  • 17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-9-alpha-fluoro-11-bet
  • (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro- 11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl- 6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one
  • Betamethasone Base & Salts
  • Betamethasone,9α-Fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione, 9α-Fluoro-16β-methylprednisolone
  • Betamethasone (200 mg)
  • BetaMethasone (Celestone)
  • BetaMethasone SolutioM
  • Betacortil
  • (8S,9R,10S,11S,13S,14S,16S,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-7,8,11,12,13,15,16,17-octahydro-6H-cyclopenta[a]phenanthren-3(9H,10H,14H)-one
  • 6beta)-
  • 9-alpha-Fluoro-11-beta,17,21-trihydroxy-16-beta-methylpregna-1,4-diene-3,20-dione
  • Cidoten
  • Corticosterone, 1-dehydro-9-fluoro-17-hydroxy-16beta-methyl-
  • Desacort-beta
  • Hormezon
  • Methazon
  • NSC-39470
  • Prednisolone, 9-fluoro-16beta-methyl-
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11beta,16beta)-
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11beta,17,21-trihydroxy-16beta-methyl-
  • pregna-1,4-diene-3,20-dione,9-fluoro-11,17,21-trihydroxy-16-methyl-,(11beta,1
  • Rinderon
  • Visubeta
  • BETAMETHASONE(RG)
  • 24: PN: US20030109453 SEQID: 23 claimed sequence
  • 9-Fluoro-11b,17,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione
  • 9-Fluoro-16β-methylprednisolone
  • 9α-Fluoro-16β-methyl-1,4-pregnadiene-11β,17α,21-triol-3,20-dione
  • 9α-Fluoro-16β-methylprednisolone
  • Bedifos
  • Bifas
  • Celeston
  • Colircusi betamida
  • Diprospan
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17,21-trihydroxy-16-methyl-, (11β,16β)-
  • Pregna-1,4-diene-3,20-dione, 9-fluoro-11b,17,21-trihydroxy-16β-methyl- (8CI)
  • Rinderon A
  • β-Methasone
  • β-Methasone alcohol
  • 9α-Fluoro-16β-methylprednisolone, 9α-Fluoro-11β,17α,21-trihydroxy-16β-methylpregna-1,4-diene-3,20-dione, 9α-Fluoro-16β-methyl-11β,17α,21-trihydroxy-1,4-pregnadiene-3,20-dione
  • Betalon
  • NoReumar
  • Novocort
  • Pertene
  • 9a-Fluoro-16-methylprednisolone
  • (11beta,16beta)-9-Fluro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
  • 9-alpha-fluoro-11-beta,17-alpha,21-trihydroxy-16-beta-methylpregna-1,4-diene
  • 9-alpha-fluoro-16-beta-methyl-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,20
  • 9-alpha-Fluoro-16-beta-methyl-1,4-pregnadiene-11-beta,17-alpha,21-triol-3,20-dione
  • 9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
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