STK393606 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

15-hydroxy prostaglandin dehydrogenase (15-hydroxy PGDH) is a key enzyme involved in the inactivation of PGs and related eiscosanoids. It functions by catalyzing the oxidation of primary PGs to their 15-keto metabolites. Two types of 15-hydroxy PGDH have been identified: type-I is NAD⁺-dependent primarily using eicosanoids as substrates, while type-II uses either NAD⁺ or NADP⁺ as cofactors and bears broader substrate specificity. STK393606 is a competitive inhibitor of NAD⁺-dependent type-I 15-hydroxy PGDH with an IC₅₀ value of 26.4 nM and a K_i value of 5 nM. It demonstrates selectivity for 15-hydroxy PGDH when profiled across a panel of related dehydrogenase or reductase enzymes.

STK393606 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

STK393606 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
BOC Sciences	16314854226	info@bocsci.com	United States	9923	65
MedBioPharmaceutical Technology Inc	021-69568360 18916172912	order@med-bio.cn	China	8140	58
Shanghai Yifei Biotechnology Co. , Ltd.	021-65675885 18964387627	customer_service@efebio.com	China	11974	58
ApexBio Technology	--	sales@apexbt.com	United States	6251	58

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• STK393606
• 2-(6-Bromo-3H-imidazo[4,5-b]pyridin-2-ylsulfanylmethyl)-benzonitrile
• 2-[(6-bromo-1H-imidazo[4,5-b]pyridin-2-yl)sulfanylmethyl]benzonitrile
• Benzonitrile, 2-[[(6-bromo-3H-imidazo[4,5-b]pyridin-2-yl)thio]methyl]-
• 355827-05-3
• C14H9BrN4S