Anti-ATP-binding cassette, sub-family A (ABC1), member 7 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project
(www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these
protocols and other useful information about Prestige Antibodies and the HPA, visit .
Allgemeine Beschreibung
The ATP binding cassette subfamily A member 7 (ABCA7) gene, spanning ~32kb with 46 exons, is mapped to human chromosome 19p13.3. The gene codes for a member of ABCA subclass of ABC transporters. ABCA7 protein is mainly expressed in human leukocytes and thymus, spleen, bone marrow and in the brain.
Biochem/physiol Actions
Abca7 plays a role in phagocytosis by macrophages of apoptotic cells.Abca7 binds APOA1 and may function in apolipoprotein-mediated phospholipid efflux from cells. Abca7 may also mediate cholesterol efflux. Abca7 may regulate cellular ceramide homeostasis during keratinocytes differentiation.
Anti-ATP-binding cassette, sub-family A (ABC1), member 7 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
