2,4-(bis-1-ketohexyl)phloroglucinol Chemische Eigenschaften,Einsatz,Produktion Methoden

Biochem/physiol Actions

Hyperforin is the active ingredient in St. John′s Wort. It is used to treat depression, known to indirectly inhibit reuptake of serotonin and norepinephrine at the synapse, and recently discovered to exert its actions by directly activating TRPC6. TRPC6 is a member of the canonical transient receptor potential (TRPC) family of ion channels. DAG is the endogenous activator of this channel, and Hyperforin is the only known TRPC6-selective activator. Although it is broadly used, Hyperforin is chemically unstable. Efforts to find a stable but pharmacologically similar TRPC6 activator resulted in the discovery of Hyp9, a simplified phloroglucinol derivative. Like Hyperforin, Hyp9 inhibits serotonin reuptake and induces neurite outgrowth. It increases calcium entry into the cell and selectively increases current through TRPC6 channels.

2,4-(bis-1-ketohexyl)phloroglucinol Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2,4-(bis-1-ketohexyl)phloroglucinol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80
Suzhou bayaoke Biotechnology Co., Ltd	18626188356	926069669@qq.com	China	489	58
Energy Chemical	021-58432009 400-005-6266	marketing@energy-chemical.com	China	44918	58
Chengdu Peter-like Biotechnology Co., Ltd.	028-81700200 13308200041	2851167782@qq.com	China	11183	58

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• 1,1′-(2,4,6-Trihydroxy-1,3-phenylene)bis-1-hexanone
• 2,4-(bis-1-ketohexyl)phloroglucinol
• Hyp9
• 1-Hexanone, 1,1'-(2,4,6-trihydroxy-1,3-phenylene)bis-
• 3118-34-1