Bornan-2-on Chemische Eigenschaften,Einsatz,Produktion Methoden
ERSCHEINUNGSBILD
FARBLOSEODER WEISSE KRISTALLE MIT CHARAKTERISTISCHEM GERUCH.
PHYSIKALISCHE GEFAHREN
Staubexplosion der pulverisierten oder granulierten Substanz in Gemischen mit Luft m?glich.
CHEMISCHE GEFAHREN
Zersetzung beim Verbrennen unter Bildung giftiger Gaseund reizender Rauche. Reagiert sehr heftig mit starken Oxidationsmitteln, starken Reduktionsmittelnund chlorhaltigen L?semitteln unter Feuer- und Explosionsgefahr.
ARBEITSPLATZGRENZWERTE
TLV: 2 ppm (als TWA); 3 ppm (als STEL); Krebskategorie A4 (nicht klassifizierbar als krebserzeugend für den Menschen); (ACGIH 2005).
MAK: 2 ppm, 13 mg/m? Spitzenbegrenzung: überschreitungsfaktor II(2); (DFG 2005).
AUFNAHMEWEGE
Aufnahme in den K?rper durch Inhalation und durch Verschlucken.
INHALATIONSGEFAHREN
Beim Verdampfen bei Raumtemperatur tritt eine gesundheitssch?dliche Kontamination der Luft ein.
WIRKUNGEN BEI KURZZEITEXPOSITION
WIRKUNGEN BEI KURZZEITEXPOSITION: Die Substanz reizt die Augen, die Haut und die Atemwege. M?glich sind Auswirkungen auf das Zentralnervensystem mit nachfolgenden Kr?mpfenund Atemdepression. Aufnahme durch Verschlucken kann zum Tod führen.
LECKAGE
Belüftung. Zündquellen entfernen. Verschüttetes Material in abgedeckten Beh?ltern sammeln; falls erforderlich durch Anfeuchten Staubentwicklung verhindern. Pers?nliche Schutzausrüstung: Atemschutzger?t, A/P2-Filter für organische D?mpfe und sch?dlichen Staub.
R-S?tze Betriebsanweisung:
R11:Leichtentzündlich.
R22:Gesundheitssch?dlich beim Verschlucken.
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R20/21/22:Gesundheitssch?dlich beim Einatmen,Verschlucken und Berührung mit der Haut.
S-S?tze Betriebsanweisung:
S16:Von Zündquellen fernhalten - Nicht rauchen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
Beschreibung
Camphor was recorded in the ancient books of traditional Chinese medicine, such
as Pin Hui Jing Yao, Ben Cao Gang Mu, and Sheng Lian Fang. There has been a
long history for traditional Chinese medicine to use camphor.
Chemische Eigenschaften
Camphor, C1oH160, also known as d-2-camphanone, Japan camphor, laurel camphor,Formosa camphor,and gumcamphor,is a terpene ketone. It is
colourless solid with a characteristic odour that is obtained from the wood and bark of the camphor tree and is soluble in water and alcohol. It has two optically active forms (dextro and levo) and an optically inactive mixture (racemic) of these two forms. Camphor is used in pharmaceuticals,in disinfectants, in explosives,and to harden nitrocellulose plastics.
Physikalische Eigenschaften
Colorless to white, flammable granules, crystals or waxy semi-solid with a strong, penetrating,
fragrant or aromatic odor. Odor threshold concentration is 0.27 ppm (quoted, Amoore and
Hautala, 1983).
History
The research and development process of camphor has gone through from the natural
product extraction to the modern chemical drug synthesis. For a long time,
the Chinese extracted camphor mainly from camphor tree (Cinnamomum camphora),
root bark of bodinier cinnamon, and Yunnan camphor tree. With the development
of chemical industry, human beings started to use chemical synthesis
methods to obtain a large amount of camphor. At present, the chemical synthesis
process of camphor in China has been well developed. The synthetic camphor is
divided into industrial and pharmaceutical grades. The industrial grade camphor has
a content of up to 96% or higher, and the pharmaceutical grade camphor with high
purity can meet the standard of pharmacopeia.
Verwenden
camphor (Cinnamomum camphora) is credited with anesthetic, antiinflammatory, antiseptic, astringent, cooling, and refreshing properties, and thought to be slightly stimulating to blood circulation and function. once absorbed by the subcutaneous tissue, it combines in the body with glucoronic acid and is released through the urine. Camphor is effective for oily and acne skin treatment, and has a scent similar to eucalyptus. In high concentrations, it can be an irritant and numb the peripheral sensory nerves. natural camphor is derived from an evergreen tree indigenous to Asia, although now its synthetic substitute is often used.
Definition
A ketone occurring naturally in the wood of the cam-
phor tree (Cinnamomum camphora).
Indications
Camphor is a ketone which, when applied in 1% to 3% concentration, has mild
antipruritic effects through its anesthetic and counterirritant properties. Counterirritants
are substances that, by inducing other sensations such as coolness or warmth,
‘‘crowd out’’ the perception of pain or itch. Camphor is used in various OTC topical
analgesic products in concentrations as high as 9%.
Weltgesundheitsorganisation (WHO)
Camphor, an aromatic crystalline substance with mild local
anaesthetic activity, is available in preparations for both external application and
inhalation. The use of such preparations has precipitated convulsions in
susceptible infants. This has led several regulatory authorities to require the
inclusion of appropriate warnings on labelling.
Allgemeine Beschreibung
A colorless or white colored crystalline powder with a strong mothball-like odor. About the same density as water. Emits flammable vapors above 150°F. Used to make moth proofings, pharmaceuticals, and flavorings.
Air & Water Reaktionen
Highly flammable. Slightly soluble in water.
Reaktivit?t anzeigen
Naphthalene, Camphor, glycerol, or turpentine will react violently with chromic anhydride [Haz. Chem. Data 1967 p. 68].
Hazard
Evolves flammable and explosive vapors
when heated. Eye and upper respiratory tract irri-
tant, and anosmia. Questionable carcinogen.
Health Hazard
Vapors of camphor can irritate the eyes, nose,and throat. In humans, such irritation may be felt at >3 ppm concentration. Prolongedexposure can cause headache, dizziness, andloss of sense of smell. Ingestion can causeheadache, nausea, vomiting, and diarrhea,and at high dosages can lead to convulsion,dyspnea, and coma. High dosages can beharmful to gastrointestinal tracts, kidney,and brain.
LD50 value, intraperitoneal (mice): 3000mg/kg.
Brandgefahr
Flammable/combustible material. May be ignited by friction, heat, sparks or flames. Some may burn rapidly with flare burning effect. Powders, dusts, shavings, borings, turnings or cuttings may explode or burn with explosive violence. Substance may be transported in a molten form at a temperature that may be above its flash point. May re-ignite after fire is extinguished.
Clinical Use
Camphor is mainly used for the treatment of pruritic skin diseases, fibrous tissue
inflammation, neuralgia, and influenza.
Sicherheitsprofil
A human poison by
ingestion and possibly other routes. An
experimental poison by inhalation,
subcutaneous, and intraperitoneal routes. A
local irritant. Ingestion causes nausea,
vomiting, dizziness, excitation, and
convulsions. Mutation data reported. Used
Toxikologie
Camphor is a very toxic compound which can prove fatal for infants and children on ingestion even in very small doses. Camphor products are toxic and especially dangerous to young children. Mouthing or eating camphor can cause seizures. Applying balms or ointments in large amounts and adding it to the water of a room humidifier may also cause children to seize. The onset of symptoms may occur very quickly - as early as 5 to 20 minutes.
m?gliche Exposition
Camphor, a natural product, is used as
a plasticizer for cellulose esters and ethers; it is used in lacquers and varnishes; and in explosives and pyrotechnics formulations. It is used as a moth repellent and as a medicinal.
Carcinogenicity
Camphor was not teratogenic to rats or
rabbits when administered orally during the
fetal period of organogenesis at doses up
to 1000mg/kg body weight (bw)/day or
681mg/kg bw/day, respectively.9 Signs of
maternal toxicity included clonic convulsions,
reduced motility, and reduced body weight gain
in rats and reduced food consumption and body
weight gain in rabbits.
Versand/Shipping
UN2717 Camphor, synthetic, Hazard Class: 4.1;
Labels: 4.1-Flammable solid. UN1130 camphor oil, Hazard
Class: 3; Labels: 3-Flammable liquid
Inkompatibilit?ten
May form explosive mixture with air.
Violent, possibly explosive, reaction with strong oxidizers,
especially chromic anhydride, potassium permanganate.
May accumulate static electrical charges, and may cause
ignition of its vapors.
Waste disposal
ncineration of a solution in a
flammable solven.
Bornan-2-on Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
