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AK-2292

AK-2292 Struktur
2984506-77-4
CAS-Nr.
2984506-77-4
Englisch Name:
AK-2292
Synonyma:
AK-2292;((2-(((2S)-1-((2S)-2-((3-((5-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pent-4-yn-1-yl)(methyl)amino)-3-oxopropyl)(4-(thiazol-2-yl)phenyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamoyl)benzo[b]thiophen-5-yl)difluoromethyl)phosphonic acid;(2-{[(2S)-1-[(2S)-2-{[2-({5-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]pent-4-yn-1-yl}(methyl)carbamoyl)ethyl][4-(1,3-thiazol-2-yl)phenyl]carbamoyl}pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}-1-benzothiophen-5-yl)difluoromethyl]phosphonic acid
CBNumber:
CB713731569
Summenformel:
C52H54F2N7O10PS2
Molgewicht:
1070.13
MOL-Datei:
2984506-77-4.mol

AK-2292 Eigenschaften

Dichte
1.49±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)
storage temp. 
-10 to -25°C
L?slichkeit
DMSO: 2mg/mL, clear
Aggregatzustand
Solid
pka
1.66±0.10(predicted)
Farbe
Off-white to light yellow

Sicherheit

AK-2292 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

AK-2292 is a potent and highly selective STAT5 PROTAC degrader. AK-2292 induces STAT5A/B protein degradation in vitro and in vivo, as well as excellent selectivity for all other STAT proteins and more than 6,000 non-STAT proteins, resulting in the selective inhibition of STAT5 activity in the cell. AK-2292 effectively induces STAT5 degradation in normal mouse tissues and human chronic myeloid leukaemia (CML) mouse xenografts. It also effectively inhibits the growth of acute myeloid leukaemia (AML) cell lines.

Chemische Eigenschaften

Off-white to light yellow Solid

AK-2292 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

AK-2292 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 11)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Wuhan Jingkang en Biomedical Technology Co., Ltd
+8613720134139
 orders@jknbiochem.com China 5221 58
Wuhan Jingkangen Biomedical Technology Co., Ltd 13720134139 086-15871494362 13720134139
 orders@jknbiochem.com China 6191 58
Changsha Fuzhen Biotechnology Co.，LTD 13823398779 13823398779
 3062105966@qq.com China 3437 58
Shanghai Lollane Biological Technology Co.,Ltd. 021-52996696，15000506266 15000506266
 China 4621 55
Bide Pharmatech Ltd. 400-1647117 13681763483
 product02@bidepharm.com China 62321 58
Shanghai Tachizaki Biomedical Research Center 18014399201
 sales@chemlab-tachizaki.com China 2673 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581
 sales@chemhifuture.com China 5530 58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-025-66113011 18626450290
 cb5@aikonchem.com China 10359 58
Olix (Shanghai) Pharmaceutical Technology Co., Ltd 17316404525
 209533805@qq.com China 9976 58
nanjing 13376082704 13376082704
 3930959291@qq.com China 2904 58
  • AK-2292
  • ((2-(((2S)-1-((2S)-2-((3-((5-(2-(2,6-Dioxopiperidin-3-yl)-1-oxoisoindolin-4-yl)pent-4-yn-1-yl)(methyl)amino)-3-oxopropyl)(4-(thiazol-2-yl)phenyl)carbamoyl)pyrrolidin-1-yl)-3,3-dimethyl-1-oxobutan-2-yl)carbamoyl)benzo[b]thiophen-5-yl)difluoromethyl)phosphonic acid
  • (2-{[(2S)-1-[(2S)-2-{[2-({5-[2-(2,6-dioxopiperidin-3-yl)-1-oxo-2,3-dihydro-1H-isoindol-4-yl]pent-4-yn-1-yl}(methyl)carbamoyl)ethyl][4-(1,3-thiazol-2-yl)phenyl]carbamoyl}pyrrolidin-1-yl]-3,3-dimethyl-1-oxobutan-2-yl]carbamoyl}-1-benzothiophen-5-yl)difluoromethyl]phosphonic acid
  • 2984506-77-4
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