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NSC 23766 TETRAHYDROCHLORIDE

NSC 23766 TETRAHYDROCHLORIDE Struktur
733767-34-5
CAS-Nr.
733767-34-5
Englisch Name:
NSC 23766 TETRAHYDROCHLORIDE
Synonyma:
CS-594;CS-1187;NSC 23766;NPEC-caged-(1S;NSC23766;NSC 23766;NSC-23766 free base;NSC 23766 TETRAHYDROCHLORIDE;N6-(2-(5-(Diethylamino)pentan-2-ylamino)-6-methylpyrimidin-4-yl)-2-methylquinoline-4,6-diamine;4,6-Quinolinediamine, N6-[2-[[4-(diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-;N6-[2-(4-Diethylamino-1-methylbutylamino)-6-methylpyrimidin-4-yl]-2-methylquinoline-4,6-diamine tetrahydrochloride
CBNumber:
CB6504010
Summenformel:
C24H35N7
Molgewicht:
421.58
MOL-Datei:
733767-34-5.mol

NSC 23766 TETRAHYDROCHLORIDE Eigenschaften

storage temp. 
Desiccate at RT
L?slichkeit
Soluble in DMSO (50 mg/ml); Water (50 mg/ml)
Aggregatzustand
White powder solid.
Farbe
White
Wasserl?slichkeit
Soluble in water.
Sensitive 
Light Sensitive & Hygroscopic
Stabilit?t:
Stable for 1 year from date of purchase as supplied. Solutions in DMSO or distilled water may be stored at -20°C for up to 3 months.

Sicherheit

NSC 23766 TETRAHYDROCHLORIDE Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

The compound blocks activation by the guanine nucleotide exchange factors Trio and Tiam1, but does not affect interactions with RhoA or Cdc42. NSC23766 blocks ADP-mediated platelet aggregation. Inhibition of Rac1 by NSC23766 restores sensitivity to trastuzumab by restoring down-regulation of ErbB2. Membrane type 1-matrix metalloproteinases (MT-1MMP) expression in CB CD34+ cells has been reported to decrease in the presence of NSC 23766. Silveta compress investigations indicate that NSC 23766 depolarizes endomembrane cycling, altered polar adhesive secretion, and tip growth.

Biologische Aktivit?t

Selective inhibitor of Rac1-GEF interaction. Prevents Rac1 activation by Rac-specific guanine nucleotide exchange factors (GEFs) TrioN and Tiam1 (IC 50 ~ 50 μ M) without affecting Cdc42 or RhoA activation. Inhibits Rac1-mediated cell functions and reported to reverse tumor cell phenotyes in prostate cancer cells.

NSC 23766 TETRAHYDROCHLORIDE Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

NSC 23766 TETRAHYDROCHLORIDE Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 98)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
Coresyn Pharmatech Co., Ltd. 		+86-571-86626709 +86-18157142896
 cbc@coresyn.com China 9984 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131957 58
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037
 3bsc@sina.com China 15839 69
VDM Biochemicals 0330-2528181
sales@vdmbio.com United States 510 64
QINGDAO CARELONGPHARMATECH CO.,LTD 0532-0532-88191853 13061484198
 sales@carelongchem.com China 413 57
Shanghai Aladdin Bio-Chem Technology Co.,LTD 400-400-6206333 18521732826
 market@aladdin-e.com China 25003 65
AdooQ Bioscience CHINA 025-58849295 18951903616;
 info@adooq.cn China 2990 60

733767-34-5()Verwandte Suche:

  • NSC 23766 TETRAHYDROCHLORIDE
  • N6-[2-[[4-(DIETHYLAMINO)-1-METHYLBUTYL]AMINO]-6-METHYL-4-PYRIMIDINYL]-2-METHYL-4,6-QUINOLINEDIAMINE TRIHYDROCHLORIDE
  • NSC 23766
  • N6-[2-(4-Diethylamino-1-methylbutylamino)-6-methylpyrimidin-4-yl]-2-methylquinoline-4,6-diamine tetrahydrochloride
  • N6-(2-(5-(Diethylamino)pentan-2-ylamino)-6-methylpyrimidin-4-yl)-2-methylquinoline-4,6-diamine
  • NSC23766;NSC 23766
  • CS-1187
  • CS-594
  • NSC-23766 free base
  • 4,6-Quinolinediamine, N6-[2-[[4-(diethylamino)-1-methylbutyl]amino]-6-methyl-4-pyrimidinyl]-2-methyl-
  • NPEC-caged-(1S
  • 733767-34-5
  • C24H35N7
  • C24H35N73HCl
  • C24H38Cl3N7
  • Rac1 Inhibitor.
  • G-Protein
  • Other enzyme inhibitors and activators
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