BENZIMIDAVIR Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Treatment of cytomegalovirus infections (antiviral).

Indications

Maribavir is used to treat cytomegalovirus (CMV) infection or disease in adults and pediatric patients 12 years and older weighing at least 35 kg who have undergone transplantation and are resistant or refractory to conventional therapy (including ganciclovir, valganciclovir, cidofovir, or fomaliclovir).

Synthese

Maribavir is synthesized from 4,5-dichloro-1,2-phenylenediamine through a series of chemical reactions. The specific reaction route is as follows:
4,5-dichloro-1,2-phenylenediamine (4.1) reacts with isopropyl isothiocyanate in pyridine and generates benzimidazole (4.2) in the presence of desulfurization agent N-cyclohexyl-N'-(2-morpholinoethyl)carbodiimide methyl p-toluenesulfonate (Morpho-CDI) with a yield of 72%. Then, this benzimidazole is coupled with 1,2,3,5-tetra-O-acetyl-β-L-ribofuranoside (4.3) under Vorbrüggen conditions (N,O-bis(trimethylsilyl)acetamide, trimethylsilane trifluoromethanesulfonate) to generate ribofuranoside (4.4) with a yield of 80-90%. Due to the participation of the ortho-O-acetyl group, the synthesis process follows Baker’s 1,2-cis rule, thus forming the target isomer. It is worth noting that the non-natural L-sugar configuration significantly affects the anti-CMV mechanism of the drug and significantly improves the pharmacokinetic properties of the drug. Finally, Maribavir (4) was obtained by deacetylation using sodium carbonate in an ethanol/water mixed solvent with a yield of 85-90%.

BENZIMIDAVIR Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

BENZIMIDAVIR Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	33024	60
Jinan Carbotang Biotech Co.,Ltd.	+8615866703830	figo.gao@foxmail.com	China	8497	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63687	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12190	58
TargetMol Chemicals Inc.	+17819995354	marketing@targetmol.com	United States	32277	58
Shanghai UCHEM Inc.	+862156762820 +86-13564624040	sales@myuchem.com	China	8032	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10473	58
NewCan Biotech Limited	+86-0571-86912261 +8613735419629	sales@newcanbio.com	China	9985	58
Wuhan Demeikai Biotechnology Co., Ltd	+8618942921723	info@dmksw.xin	China	717	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6391	58

176161-24-3()Verwandte Suche:

---

• 5,6-Dichloro-N-(1-methylethyl)-1-beta-L-ribofuranosyl-1H-benzimidazol-2-amine
• BW 1263W94
• GW 257406X
• (2S,3S,4R,5S)-2-(5,6-Dichloro-2-(isopropylamino)-1H-benzo[d]imidazol-1-yl)-5-(hydroxymethyl)tetrahydrofuran-3,4-diol
• (2S,3S,4R,5S)-2-(5,6-Dichloro-2-(isopropylamino)-1H-benzo[d]-imidazol-1-yl)-5-(hydroxymethyl)t
• 5,6-DICHLORO-2-(ISOPROPYLAMINO)-1-(BETA-L-RIBOFURANOSYL)-1H-BENZIMIDAZOLE
• BENZIMIDAVIR
• BENZIMIDAVIR, 5,6-DICHLORO-2-（ISOPROPYLAMINO）-1-(β-L-RIBOFURANOSYL)-LH-BENZIMIDAZOLE
• 5,6-DICHLORO-2-ISOPROPYLAMINO-1-(-L-RIBOFURANOSYL)-LH-BENZIMIDAZOLE
• BENZIMIDAVIR: 5,6-DICHLORO-2-(ISOPROPYLAMINO)-1-(SS-L-RIBOFURANOSYL)-LH-BENZIMIDAZOLE
• (2S,3S,4R,5S)-2-(5,6-Dichloro-2-(isopropylamino)-1H-benzo[d]-imidazol-1-yl)-5-(hydroxymethyl)tetr
• 1263W94
• 1H-Benzimidazol-2-amine, 5,6-dichloro-N-(1-methylethyl)-1-β-L-ribofuranosyl-
• Maribavi
• Maribavir
• Malibawei
• Malibave.
• Maribavir Impurity Crystal-Free Type VI
• Maribavir, 10 mM in DMSO
• 176161-24-3
• 76161-24-3
• C15H19Cl2N3O4
• Inhibitors