Protein phosphatase 1M Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Anti-PPM1M (C-terminal) antibody is suitable for use in immunoprecipitation (2.5-5.0 μg) using lysates of HEK-293T cells over-expressing human PPM1M. The product may also be used for western blot (approx. 33 kDa).
Allgemeine Beschreibung
PPM1M is a member of the PP2C family of Ser/Thr protein phosphatases. PP2C family members are known to be negative regulators of cell stress response pathways. This phosphatase was identified as an interacting protein of Rho guanine nucleotide exchange factors (PIX). PIX proteins are regulators of p21/Cdc42/Rac1-activated kinase 1 (PAK1), a protein kinase mediating biological effects downstream of Rho GTPases. This phosphatase has been shown to block the effects of PAK, and thus inhibit actin stress fiber breakdown and morphological changes driven by cell division cycle 42 (CDC42).
Biochem/physiol Actions
Decreased PPM1M gene expression is associated with the inhibition of Herpes simplex virus 1 (HSV-1) infection.
Protein phosphatase 1M Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
