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5-Ethynyl-2'-deoxycytidine

5-Ethynyl-2'-deoxycytidine Struktur
69075-47-4
CAS-Nr.
69075-47-4
Englisch Name:
5-Ethynyl-2'-deoxycytidine
Synonyma:
5-Ethynyl-2'-dC;-Ethynyl-2’5-Ethynyl-2'-deoxycytidine;5-Ethynyl-2'-deoxycytidine;2'-Deoxy-5-ethynylcytidine;5'-Ethynyl-2'-deoxycytidine;5-Ethynyl-2'-deoxycytidine>Cytidine, 2'-deoxy-5-ethynyl-;5-Ethynyl-2′-deoxycytidine, (EdC);5-Ethynyl-2'-deoxycytidine 69075-47-4
CBNumber:
CB62682226
Summenformel:
C11H13N3O4
Molgewicht:
251.24
MOL-Datei:
69075-47-4.mol

5-Ethynyl-2'-deoxycytidine Eigenschaften

Schmelzpunkt:
191 °C (decomp)(Solv: dichloromethane (75-09-2); methanol (67-56-1))
Siedepunkt:
475.7±55.0 °C(Predicted)
Dichte
1.54±0.1 g/cm3(Predicted)
storage temp. 
Store at 2-8°C, protect from light, stored under nitrogen
L?slichkeit
DMF: 5 mg/ml; DMSO: 20 mg/ml; PBS (pH 7.2): 10 mg/ml
pka
14.03±0.60(Predicted)
Aggregatzustand
powder to crystal
Farbe
White to Light yellow to Light orange
maximale Wellenl?nge (λmax)
292nm(H2O)(lit.)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
WGK Germany  3
HS Code  2934.99.4400
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

5-Ethynyl-2'-deoxycytidine Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

5''-Ethynyl-2''-deoxycytidine (EdC) is a nucleoside analog that inhibits replication of the herpes simplex virus-1 (HSV-1) KOS strain (ID50 = 0.2 μg/mL). It also reduces virus-induced cytopathogenicity of HSV-1, HSV-2, and vaccinia virus strains in PRK cells (MICs = 0.2-0.4, 1-2, and 5 μg/ml, respectively). EdC is an inhibitor of thymidylate synthetase, selectively reducing DNA incorporation of [1'',2''-3H]deoxyuridine over [CH3-3H]deoxythymidine in PRK cells (ID50s = 3 and 120 μg/ml, respectively). It inhibits thymidine synthetase in and reduces proliferation of L1210 cells, an effect which is reversed by addition of deoxythymidine (ID50s = 4.4 and 1,000 μg/ml, respectively). EdC has been used to monitor DNA synthesis and cellular replication via click chemistry conjugation of the ethynyl group to an azido group of various fluorochromes.

Verwenden

5-Ethynyl-2’-deoxycytidine is an lower toxicity analog of 2’-deoxycytidine, a metabolic labeling probe for DNA synthesis. 5-Ethynyl-2’-deoxycytidine is most commonly used when thymidine analogs is undesirable.

5-Ethynyl-2'-deoxycytidine Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

5-Ethynyl-2'-deoxycytidine Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

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  • 5-Ethynyl-2′-deoxycytidine, (EdC)
  • Cytidine, 2'-deoxy-5-ethynyl-
  • 2'-Deoxy-5-ethynylcytidine
  • 5-Ethynyl-2'-deoxycytidine, (EdC) AldrichCPR
  • 5-Ethynyl-2'-deoxycytidine
  • 5-Ethynyl-2'-dC
  • 4-Amino-5-ethynyl-1-((2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)tetrahydrofuran-2-yl)pyrimidin-2(1H)-one
  • -Ethynyl-2&rsquo
  • 5-Ethynyl-2'-deoxycytidine>
  • 5-Ethynyl-2'-deoxycytidine 69075-47-4
  • 5-Ethynyl-2'-deoxycytidine
  • 5'-Ethynyl-2'-deoxycytidine
  • 5-Ethynyl-2''-deoxycytidine (5-EdC), DNA synthesis monitoring probe
  • 69075-47-4
  • Carbohydrates & Derivatives, Heterocycles, Nucleotides, Bases & Related Reagents
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