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azalanstat

azalanstat Struktur
143393-27-5
CAS-Nr.
143393-27-5
Englisch Name:
azalanstat
Synonyma:
Rs-21607;Rs 21607;azalanstat;Unii-2nl79ni1ws;Azalanstat [inn];Azalanstat mesylate;Benzenamine, 4-[[[(2S,4S)-2-[2-(4-chlorophenyl)ethyl]-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl]thio]-;Benzenamine, 4-(((2-(2-(4-chlorophenyl)ethyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methyl)thio)-, (2S-cis)-
CBNumber:
CB61377064
Summenformel:
C22H24ClN3O2S
Molgewicht:
429.96
MOL-Datei:
143393-27-5.mol

azalanstat Eigenschaften

Schmelzpunkt:
151 °C
Siedepunkt:
647.7±40.0 °C(Predicted)
Dichte
1.31±0.1 g/cm3(Predicted)
pka
6.88±0.12(Predicted)

Sicherheit

azalanstat Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

Hypolipidemic.

Enzyminhibitor

This imidazole-containing agent (FW = 429.96 g/mol), also known as RS- 21607, inhibits both inducible heme oxygenase-1 and constitutive heme oxygenase-2 (rat IC50 = 5.3 and 24.5 μM, respectively). The m aminophenyl analogue is a slightly stronger inhibitor of heme oxygenase-1 (IC50 = 1 μM). Azalanstat is a stronger inhibitor of lanosterol 14a demethylase (rat and human Ki = 2.5 and 0.79 nM, respectively). The other three stereoisomers are weaker inhibitors of the demethylase. Target(s): aromatase, or CYP19; cholestanetriol 26-monooxygenase, or cholesterol 27-monooxygenase; cholesterol 7a-monooxygenase (CYP7)3,4; cholesterol monooxygenase, side-chain cleaving; CYP1A1; CYP1A2; CYP2C9; CYP2D6; heme oxygenase; progesterone 6b-monooxygenase, or CYP3A; progesterone 16a monooxygenase; steroid 11b monooxygenase; steroid 17a monooxygenase, or steroid 17a/20-lyase; steroid 21 monooxygenase; sterol 14-demethylase, or CYP5; lanosterol 14a-demethylase.

azalanstat Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Peroxyessigs?ure ...% Methansulfonylchlorid Natriumhydroxid Bromethylen 4-Aminobenzolthiol p-Chlorphenethylalkohol Natriumhydrid Oxalyldichlorid p-Toluenesulfonic acid monohydrate Natriumacetat Triphenylphosphin N,N-Diethylethanamin Kaliumcarbonat N-Bromsuccinimid Imidazol Glycerol

Downstream Produkte

azalanstat Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 4)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Suzhou Meishi Biotechnology Co., Ltd. 1173954148q
 meishipharma@126.com China 20033 58
Nantong QuanYi Biotechnology Co., Ltd 0513-66337626 18051384581
 sales@chemhifuture.com China 5018 58
TargetMol Chemicals Inc. 15002134094
 marketing@targetmol.cn China 19700 58
  • azalanstat
  • Azalanstat [inn]
  • Benzenamine, 4-(((2-(2-(4-chlorophenyl)ethyl)-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl)methyl)thio)-, (2S-cis)-
  • Rs 21607
  • Rs-21607
  • Unii-2nl79ni1ws
  • Benzenamine, 4-[[[(2S,4S)-2-[2-(4-chlorophenyl)ethyl]-2-(1H-imidazol-1-ylmethyl)-1,3-dioxolan-4-yl]methyl]thio]-
  • Azalanstat mesylate
  • 143393-27-5
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