Calpain Inhibitor I
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- CAS-Nr.
- 110044-82-1
- Englisch Name:
- Calpain Inhibitor I
- Synonyma:
- ALLN;LLNL;MG 101;ac-llnl-cho;MG-101 (ALLN);InSolution? ALLN;Ac-Leu-Leu-Nle-al;AC-LL-NORLEUCINAL;CALPAIN INHIBITOR;AC-LEU-LEU-NLE-CHO
- CBNumber:
- CB6108214
- Summenformel:
- C20H37N3O4
- Molgewicht:
- 383.53
- MOL-Datei:
- 110044-82-1.mol
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Calpain Inhibitor I Eigenschaften
- Schmelzpunkt:
- 182 °C
- Siedepunkt:
- 510.42°C (rough estimate)
- Dichte
- 1.1322 (rough estimate)
- Brechungsindex
- 1.6300 (estimate)
- storage temp.
- 2-8°C
- L?slichkeit
- DMSO: soluble
- Aggregatzustand
- powder
- pka
- 13.53±0.46(Predicted)
- Farbe
- white
- Biologische Quelle
- synthetic (organic)
- Wasserl?slichkeit
- Soluble in dimethyl sulfoxide, ethanol, methanol. Insoluble in water, and aqueous buffers.
- BRN
- 7656053
- Stabilit?t:
- Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month.
Calpain Inhibitor I Chemische Eigenschaften,Einsatz,Produktion Methoden
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
Chemische Eigenschaften
white to off-white powder
Verwenden
It inhibits apoptosis in thymocytes and metamyelocytes. It also inhibits cell cycle progression at the G1/S border and metaphase/anaphase in CHO cells by inhibiting cyclin B degradation. ALLN inhibits the proteolysis of IκBα and IκBβ by the ubiquitin-proteasome complex. ALLN also prevents nitric oxide production by activated macrophages by interfering with transcription of the inducible nitric oxide synthase gene.
Definition
ChEBI: A tripeptide composed of N-acetylleucyl, leucyl and norleucinal residues joined in sequence.
Allgemeine Beschreibung
Calpain Inhibitor I is a strong, competitive inhibitor of the Ca
2+-dependent neutral cysteine proteases calpain I and calpain II.
Biologische Aktivit?t
Calpain inhibitor (IC 50 = 0.09 μ M) that activates p53-dependent apoptosis in tumor cell lines. Increases activated p53, p21 and caspase levels and promotes cell cycle arrest through inhibition of cyclin D degradation in vitro . Also attenuates ischemia/reperfusion injury in cardiomyocytes, hepatocytes and renal tubular cells through downregulation of iNOS and COX-2 expression.
Calpain Inhibitor I Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
Calpain Inhibitor I Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 120)Lieferanten
- AC-LEU-LEU-NLE-H (ALDEHYDE)
- AC-LEU-LEU-NORLEUCINAL
- AC-LL-NORLEUCINAL
- ac-llnl-cho
- Ac-Leu-Leu-Nle-al
- Ac-LLnL-CHO, ALLN, MG-101, N-Acetyl-Leu-Leu-Norleu-al, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal
- Calpain Inhibitor I,96%
- N-Acetyl-L-leucine-L-leucine-L-norleucinal
- N-Acetyl-Leu-Leu-Norleu-al
- Calpain Inhibitor I, ALLN
- ALLN, Ac-LLnL-CHO, MG-101, N-Acetyl-Leu-Leu-Norleu-al, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal
- N-Acetyl-L-leucinyl-L-leucinyl-L-norleucinal
- Calpain Inhibitor Ⅰ 〔N-Acetyl-L-leucyl-L-leucyl-L-norleucinal〕
- InSolution? ALLN
- MG-101 (ALLN)
- N-acetyl-L-leucyl-N-[(1S)-1-formylpentyl]-L-Leucinamide
- ALLN
- acetylleucyl-leucyl-norleucinal
- N-AC-LEU-LEU-NORLEUCINAL
- N-ACETYL-LEU-LEU-NLE-CHO
- N-ACETYL-L-LEUCYL-L-LEUCYL-L-NORLEUCINAL
- N-ACETYL-LEU-LEU-NORLEUCINAL
- MG 101
- LLNL
- CALPAIN INHIBITOR
- CALPAIN INHIBITOR I
- ACETYL-LEU-LEU-NORLEUCINAL
- ACETYL-L-LEUCYL-L-LEUCYL-L-NORLEUCINAL
- AC-LEU-LEU-L-NORLEUCINAL
- AC-LEU-LEU-NLE-ALDEHYDE
- AC-LEU-LEU-NLE-CHO
- CALPAIN INHIBITOR I;AC-LLNL-CHO;ALLN
- (S)-2-acetamido-N-((S)-1-amino-4-methyl-1-oxopentan-2-yl)-4-methyl-N-((S)-1-oxohexan-2-yl)pentanamide
- L-Leucinamide, N-acetyl-L-leucyl-N-[(1S)-1-formylpentyl]-
- MG-101 (Calpain inhibitor I
- InSolution ALLN - CAS 110044-82-1 - Calbiochem
- ALLN - CAS 110044-82-1 - Calbiochem
- CALPAIN INHIBITOR-1;MG101;MG-101;MG 101
- CALPAIN INHIBITOR I
- RKO,MG-101,colon cancer,Bax,HepG2,Proteasome,MG 101,Inhibitor,mitochondria,HCT116,inhibit,Apoptosis,SW480,anti-tumor
- N-Acetyl-Leu-Leu-Norleu-al, N-Acetyl-L-leucyl-L-leucyl-L-norleucinal
- ALLN (DMSO solution)
- ALLN, cysteine proteinase inhibitor
- MG-101, 10 mM in DMSO
- 110044-82-1
- C20H37N3O4
- Enzyme Inhibitors by Type
- BioChemical
- Biochemicals and Reagents
- Calpain I
- A to C
- Substrate Analogs
- Enzyme Inhibitors
- Enzyme Inhibitors by Enzyme
- Enzymes, Inhibitors, and Substrates
- inhibitor
- peptides
- ProteasomeInhibitors
