BRCA1 BRCT domains (human recombinant) Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
The BRCA1 C-
terminal (BRCT) domain is a modular unit of ~100 amino acids that folds independently and recognizes linear phosphoserine or phosphothreonine regions to mediate protein-
protein and protein-
DNA interactions. BRCT domains were initially recognized in the C-
terminal region of the breast cancer protein BRCA1, as well as the p53 binding protein (53BP1; TP53BP1), and the yeast cell cycle checkpoint protein RAD9. BRCT domains often occur as tandem repeats at the C-
terminal end of several proteins that are functionally diverse. Most BRCT domain-
containing proteins participate in DNA-
damage checkpoint control or DNA-
repair pathways, or both. Thus, BRCT domain-
containing proteins likely participate in the cellular response to DNA damage.Germ-
line mutations of the tumor suppressor genes BRCA1 and BRCA2 pre-
dispose women to familial breast and ovarian cancer and are associated with approximately 10% of the cases. The carboxy-
terminal BRCT domain in BRCA1 is involved in DNA repair and transcriptional activation. The BRCT region of BRCA1 binds phosphorylated BACH1, a DEAH helicase, which is essential for mediating repair of DNA double-
strand breaks by controlling G
2 to M phase transition during cell cycle progression. BRCA1 also contains an N-
terminal protein-
protein-
interaction RING-
finger domain, that partners with BRCA1-
associated RING domain 1 (BARD1). The BRCA1/BARD1 heterodimer maintains genomic stability by regulating DNA damage repair and ubiquitination. This product contains the BRCT domains of BRCA1.
BRCA1 BRCT domains (human recombinant) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
