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Chlortetracyclin

Chlortetracycline Struktur
57-62-5
CAS-Nr.
57-62-5
Bezeichnung:
Chlortetracyclin
Englisch Name:
Chlortetracycline
Synonyma:
CHLOROTETRACYCLINE;Clortetraciclina;Chlortetracyclin;Chlortetracycline Premix;aureomykoin;Aurofac;flamycin;duomycin;acronize;Biovetin
CBNumber:
CB5408663
Summenformel:
C22H23ClN2O8
Molgewicht:
478.88
MOL-Datei:
57-62-5.mol

Chlortetracyclin Eigenschaften

Schmelzpunkt:
168-169°
alpha 
D23 -275.0° (methanol)
Siedepunkt:
821.1±65.0 °C(Predicted)
Dichte
1.2833 (rough estimate)
Brechungsindex
1.6000 (estimate)
storage temp. 
2-8°C
L?slichkeit
DMF: Soluble; DMSO: Soluble; Ethanol: Soluble; Methanol: Soluble
Aggregatzustand
A solid
pka
pKa 3.3 (Uncertain)
Wasserl?slichkeit
0.63g/L(25 ºC)
LogP
-0.620
CAS Datenbank
57-62-5(CAS DataBase Reference)
EPA chemische Informationen
Chlortetracycline (57-62-5)
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22
WGK Germany  1
RTECS-Nr. QI7750000
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
Sicherheit
P264 Nach Gebrauch gründlich waschen.
P264 Nach Gebrauch gründlich waschen.
P270 Bei Gebrauch nicht essen, trinken oder rauchen.
P301+P312 BEI VERSCHLUCKEN: Bei Unwohlsein GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen.
P330 Mund ausspülen.
P501 Inhalt/Beh?lter ... (Entsorgungsvorschriften vom Hersteller anzugeben) zuführen.

Chlortetracyclin Chemische Eigenschaften,Einsatz,Produktion Methoden

R-S?tze Betriebsanweisung:

R22:Gesundheitssch?dlich beim Verschlucken.

Beschreibung

Chlortetracycline (Brand name: Aureomycin) is the 7-chloro substitution derivative of the tetracycline and has a golden color. As a veterinary medicine, chlortetracycline is commonly used for the treatment of conjunctivitis of cats. It can also be used in the treatment of infections occurring in the urinary tract, respiratory tract, and the intestines. Its mechanism of action is through inhibiting the protein synthesis, inhibiting the binding of aminoacyl-tRNA to the mRNA-ribosome complex through binding to the 30S ribosome subunit.

Chemische Eigenschaften

Golden-yellow crystalline powder, odorless with a bitter taste; decomposes at a melting point of 168-169°C. Slightly soluble in water but soluble in saline solutions. The hydrochloride form is slightly soluble in methanol, water, and ethanol and insoluble in acetone, ether, and chloroform. Stable in air, but the colour gradually darkens upon exposure to light.

Verwenden

Chlortetracycline was the first reported member of the tetracycline class, isolated from Streptomyces aureofaciens in 1948. Chlortetracyclines heralded the early wave of antibiotic discoveries from microbes and after 50 years are still widely used as pharmaceuticals. Chlortetracycline is a pigment and, like most pigments, is extremely sensitive to environmental and storage conditions. Commercial chlortetracycline may contain significant levels of degradation products.

Indications

Chlorotetracycline, an antibiotic with a broad spectrum of action, causes a bacteriostatic effect with respect to Gram-positive (staphylococci, including those that produce penicillinase; streptococci, pneumococci; clostridia, listeria, and anthrax bacillus) and Gram-negative microorganisms (gonococci, whooping cough bacillus, colon bacillus, enterobacteria, klebisella, salmonella, shigella), as well as Rickettsia, chlamydia, mycoplasma, and spirochaeta. Blue-pus bacillus, proteus, serracia, most strains of Bacteroides fragilis, most fungi, and small viruses are resistant to this drug. It is used for pneumonia, bronchitis, empyema of the lungs, angina, cholecystitis, whooping cough, endocarditis, endometritis, intestinal infections, prostatitis, syphilis, gonorrhea, brucellosis, osteomyelitis, purulent infections of soft tissues, and others caused by microorganisms sensitive to this drug. Synonyms of this drug are aureomycin, biomycin, xanthomycin, and others.

Definition

ChEBI: Chlortetracycline is a member of the class of tetracyclines with formula C22H23ClN2O8 isolated from Streptomyces aureofaciens. It has a role as an antiprotozoal drug, a fluorescent probe, a calcium ionophore and an antibacterial drug. It is a member of monochlorobenzenes, a tertiary amino compound, a tertiary alcohol, a monocarboxylic acid amide, a tertiary alpha-hydroxy ketone and a member of tetracyclines. It is a conjugate acid of a chlortetracycline(1-).

Antimicrobial activity

It is slightly less active than tetracycline against many bacteria, with the exception of Gram-positive organisms.

Pharmazeutische Anwendungen

7-Chlortetracycline. A fermentation product of certain strains of Streptomyces aureofaciens. Formulated as the hydrochloride or the free base for oral or topical application.

Pharmakokinetik

Oral absorption:30–60%
Cmax 500 mg oral:2.5–7 mg/L:
Plasma half-life: 5–6 h
Volume of distribution: c.2 L/kg
Plasma protein binding: 47–65%
Absorption is relatively poor compared with other tetracyclines. It undergoes rapid metabolism and is largely eliminated by biliary excretion, with only a small proportion eliminated via the kidney. Despite this, chlortetracycline is not recommended for patients in renal failure, since accumulation occurs as a consequence of the half-life increase to approximately 7–11 h.

Clinical Use

Its uses are those common to the group. It has also been used topically in the management of recurrent aphthous ulcers of the mouth, but experience is limited and the mechanism of action is unknown.

Nebenwirkungen

Side effects are typical of the group. Contact hypersensitivity has been reported with topical application to abraded skin and varicose ulcers.

Sicherheitsprofil

Poison by intravenous and intraperitoneal routes. Moderately toxic by ingestion. Experimental reproductive effects. When heated to decomposition it emits toxic fumes of Cland NOx. See also TETRACYCLINE.

l?uterung methode

Aureomycin is dehydrated by azeotropic distillation of its solution with toluene. On cooling, the anhydrous material crystallises out and is recrystallised from *C6H6, then dried under vacuum at 100o over paraffin wax. (If it is crystallised from MeOH, it contains MeOH which is not removed on drying.) [Stephens et al. J Am Chem Soc 76 3568 1954, Laskin & Chan Biochem Biophys Res Commun 14 137 1964]. [Beilstein 14 IV 2631.]

Chlortetracyclin Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Chlortetracyclin Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 197)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Chuanghai Biotechnology Co,.LTD
+86-13131129325
sales1@chuanghaibio.com China 5878 58
Shaanxi TNJONE Pharmaceutical Co., Ltd
+8618092446649
sarah@tnjone.com China 1143 58
Henan Tianfu Chemical Co.,Ltd.
+86-0371-55170693 +86-19937530512
info@tianfuchem.com China 21631 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 - 03@
sales03@shyrchem.com CHINA 738 60
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679 +8618949832763
info@tnjchem.com China 2986 55
career henan chemical co
+86-0371-86658258 +8613203830695
sales@coreychem.com China 29865 58
Hubei Jusheng Technology Co.,Ltd.
18871490254
linda@hubeijusheng.com CHINA 28172 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 904 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49732 58

57-62-5(Chlortetracyclin)Verwandte Suche:


  • acronize
  • aureocina
  • aureomycina-377
  • biomitsin
  • chlortetracycline
  • chrysomykine
  • duomycin
  • flamycin
  • ydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-,[4s-(4alpha,4aalpha,5a
  • 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-2-naphthacenecarboxamide
  • Acronize PD
  • Aureocarmyl
  • Aureociclin
  • Aureomicina
  • Aureomycin-R
  • Aurofac
  • Chlortetracycline (15%)
  • 10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-ydro-6
  • 7-chlorotetracycline
  • Aurofac 10
  • Biomycin A
  • Biovetin
  • Chlortetracyclinum
  • Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S-(4alpha,4aalpha,5aalpha,6beta,12aalpha))-
  • Streptomyces aureofaciens antibiotic
  • CHLORTETRACYCLINE HCL ( VETERINARY)
  • auromycin
  • Chlorotetracycline HCL(Vet)
  • ChlorotetracyclineF.G.powder
  • F.G.granulated
  • Chlorotetracyclinebaseand/orunspecifiedsalts
  • 2-Naphthacenecarboxamide, 7-chloro-4-(dimethylamino)-1,4,4a,5,5a,6,11,12a-octahydro-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-, (4S,4aS,5aS,6S,12aS)-
  • aureomycine
  • chlortetracycline,calcium salt
  • Feed aureomycin powder
  • Chlorotetracycline, Chlortetracycline
  • Uromycin
  • Chlortetracycline Selective Supplement,Chlorotetracycline, Chlortetracycline
  • Chlortetracycline, AureoMycin
  • Chlortetracycline base
  • AureoMycin, Chlorotetracycline, BioMycin
  • (4S,4aS,5aS,6S,12aS)-7-Chloro-4-(dimethylamino)-3,6,10,12,12a-pentahydroxy-6-methyl-1,11-dioxo-1,4,4a,5,5a,6,11,12a-octahydrotetracene-2-carboxamide
  • Chlortetracycline USP/EP/BP
  • CHLORTETRACYCLINE CA
  • Chlorotetracyclin
  • Animals Pharmaceutical 7-Chlorotetracycline Feed Additive Chlortetracycline CAS 57-62-5
  • Chlorotetracycline (API)
  • aureomykoin
  • CHLOROTETRACYCLINE
  • Clortetraciclina
  • Chlortetracyclin
  • Chlortetracycline Premix
  • Chlortetracycline HCG
  • Lymecycline EP Impurity G(Chlortetracycline)
  • Paracetamol Impurity 41
  • Tetracycline impurity 18
  • 57-62-5
  • C22H23CIN2O8
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