Purin-6(1H)-on Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R36/37/38:Reizt die Augen, die Atmungsorgane und die Haut.
R22:Gesundheitssch?dlich beim Verschlucken.
R40:Verdacht auf krebserzeugende Wirkung.
S-S?tze Betriebsanweisung:
S22:Staub nicht einatmen.
S24/25:Berührung mit den Augen und der Haut vermeiden.
S37/39:Bei der Arbeit geeignete Schutzhandschuhe und Schutzbrille/Gesichtsschutz tragen.
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Hypoxanthine is a naturally occurring purine derivative and intermediate in the synthesis of uric acid. It is elevated in the spinal fluid of patients with Lesch-Nyhan syndrome, a metabolic disorder whose symptoms include cerebral palsy, cognitive deficits, motor dysfunction, self-mutilation, and hyperuricemia. Injection of hypoxanthine (10 μM) increases succinate dehydrogenase and complex II activities and decreases cytochrome c oxidase activity, resulting in neuroenergetic impairment, ATP depletion, and cellular apoptosis in rat striatum. It is also used to induce hyperuricemia in mice for use in the development of hypouricemic agents.
Chemische Eigenschaften
White to off-white powder
Verwenden
A naturally occurring purine derivative. Pharmaceuticals, Intermediates & Fine Chemicals
Definition
ChEBI: A purine nucleobase that consists of purine bearing an oxo substituent at position 6.
Allgemeine Beschreibung
Hypoxanthine (6-hydroxypurine), a purine derivative is a naturally occurring compound. It is the deaminated form of adenine and a breakdown product of adenosine monophosphate (AMP).
Sicherheitsprofil
Moderately toxic by
intraperitoneal route. An experimental
teratogen. When heated to decomposition it
emits toxic fumes of Nox
l?uterung methode
Crystallise it from hot water and dry it at 105o. [Beilstein 26 II 252, 26 III/IV 2081.]
Purin-6(1H)-on Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte