Anti-Vaccinia-related kinase 1 Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Anti-VRK1 antibody produced in rabbit, a Prestige Antibody, is developed and validated by the Human Protein Atlas (HPA) project
(www.proteinatlas.org). Each antibody is tested by immunohistochemistry against hundreds of normal and disease tissues. These images can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. The antibodies are also tested using immunofluorescence and western blotting. To view these
protocols and other useful information about Prestige Antibodies and the HPA, visit .
Allgemeine Beschreibung
Vaccinia-related kinase 1 (VRK1) is a nucleosomal kinase belonging to a group of serine/threonine kinases which are associated with breast carcinomas. The gene encoding VRK1 is located on human chromosome 14.
Biochem/physiol Actions
Vaccinia-related kinase 1 (VRK1) phosphorylates many transcription factors like tumor suppressor p53 and c-Jun (a kinase). It controls cell-cycle progression wherein it is required for exit from G0 phase and entry into G1 phase. VRK1 interacts with proteins like histones of the chromatin network and is essential for chromatin condensation. It has been shown to phosphorylate histone H3. VRK1 plays an important role in response to DNA damage by UV-light and radiations.
Anti-Vaccinia-related kinase 1 Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
