N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester
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- CAS-Nr.
- 1401089-31-3
- Englisch Name:
- N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester
- Synonyma:
- PACMA 31;PACMA 31 >=98% (HPLC);PACMA 31, 10 mM in DMSO;Ethyl 2-(2-(N-(2,4-dimethoxyphenyl)propiolamido)-2-(thiophen-2-yl)acetamido)acetate;N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester;Glycine, N-(2,4-dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-, ethyl ester;bond,tumor,ovarian,athymic,PACMA31,inhibit,toxicity,colony,PACMA-31,mice,PACMA 31,oral,Inhibitor,covalent
- CBNumber:
- CB52750694
- Summenformel:
- C21H22N2O6S
- Molgewicht:
- 430.47
- MOL-Datei:
- 1401089-31-3.mol
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N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester Eigenschaften
- storage temp.
- room temp
- L?slichkeit
- DMSO: soluble10mg/mL, clear (warmed)
- Aggregatzustand
- powder
- Farbe
- white to light brown
Sicherheit
- Risiko- und Sicherheitserkl?rung
- Gefahreninformationscode (GHS)
| Kennzeichnung gef?hrlicher |
T |
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| R-S?tze: |
25 |
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| S-S?tze: |
45 |
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| RIDADR |
UN 2811 6.1 / PGIII |
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| WGK Germany |
3 |
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| Bildanzeige (GHS) |
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| Alarmwort |
Achtung |
| Gefahrenhinweise |
| Code |
Gefahrenhinweise |
Gefahrenklasse |
Abteilung |
Alarmwort |
Symbol |
P-Code |
| H301 |
Giftig bei Verschlucken. |
Akute Toxizit?t oral |
Kategorie 3 |
Achtung |
![GHS hazard pictograms]() src="/GHS06.jpg" width="20" height="20" /> |
P264, P270, P301+P310, P321, P330,P405, P501 |
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| Sicherheit |
| P301+P310 |
BEI VERSCHLUCKEN: Sofort GIFTINFORMATIONSZENTRUM/Arzt/... (geeignete Stelle für medizinische Notfallversorgung vom Hersteller/Lieferanten anzugeben) anrufen. |
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N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
PACMA 31 is a protein disulfide isomerase family A member 1 (PDIA1) inhibitor as promising target for chemotherapy.
Biochem/physiol Actions
PACMA 31 is an orally bioavailable, selective inhibitor (IC50 = 10 μM) of protein disulfide isomerase (PDI), an endoplasmic reticulum protein that regulates oxidative protein folding by catalyzing the breakage and reformation of disulfide bonds. PDI is upregulated in ovarian, and several other cancers. PACMA 31 dose dependently inhibits proliferation of OVCAR-8 in culture and in a tumor xenograft model.
N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 41)Lieferanten
- N-(2,4-Dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-glycine ethyl ester
- PACMA 31
- Glycine, N-(2,4-dimethoxyphenyl)-N-(1-oxo-2-propyn-1-yl)-2-(2-thienyl)glycyl-, ethyl ester
- PACMA 31 >=98% (HPLC)
- bond,tumor,ovarian,athymic,PACMA31,inhibit,toxicity,colony,PACMA-31,mice,PACMA 31,oral,Inhibitor,covalent
- Ethyl 2-(2-(N-(2,4-dimethoxyphenyl)propiolamido)-2-(thiophen-2-yl)acetamido)acetate
- PACMA 31, 10 mM in DMSO
- 1401089-31-3
