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ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate

ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Struktur
4450-98-0
CAS-Nr.
4450-98-0
Englisch Name:
ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate
Synonyma:
1-Ebpc;CP-10668;Nsc 229530;EBPC, Aldose reductase inhibitor;Aldose Reductase,inhibit,EBPC,Inhibitor;1-Benzyl-4-bydroxy-5-oxo-3-pyrroline-3-carboxylic Acid Ethyl Ester;1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester;2,5-Dihydro-4-hydroxy-5-oxo-1-(phenylMethyl)-1H-pyrrole-3-carboxylic Acid Ethyl Ester;1H-Pyrrole-3-carboxylic acid, 2,5-dihydro-4-hydroxy-5-oxo-1-(phenylmethyl)-, ethyl ester
CBNumber:
CB51373216
Summenformel:
C14H15NO4
Molgewicht:
261.27
MOL-Datei:
4450-98-0.mol

ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Eigenschaften

Schmelzpunkt:
135-136 °C
Siedepunkt:
479.8±45.0 °C(Predicted)
Dichte
1.340±0.06 g/cm3(Predicted)
storage temp. 
room temp
L?slichkeit
DMSO: ≥10mg/mL
Aggregatzustand
white powder
pka
4.50±1.00(Predicted)
Farbe
white
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
Kennzeichnung gef?hrlicher Xn
R-S?tze: 22-41
S-S?tze: 26
WGK Germany  3
HazardClass  IRRITANT
Bildanzeige (GHS) GHS hazard pictogramsGHS hazard pictograms
Alarmwort Achtung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H318 Verursacht schwere Augensch?den. Schwere Augensch?digung Kategorie 1 Achtung GHS hazard pictogramssrc="/GHS05.jpg" width="20" height="20" /> P280, P305+P351+P338, P310
Sicherheit
P280 Schutzhandschuhe/Schutzkleidung/Augenschutz tragen.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

The human aldose reductase AKR1B1 is considered the rate limiting enzyme of the polyol pathway responsible for the conversion of glucose into sorbitol. It also acts as a highly efficient PGF2α synthase in response to interleukin-1β. Increased aldose reductase expression has been associated with complications of diabetes and may contribute to reduced efficacy of certain chemotherapeutic drugs. EBPC is a potent, selective inhibitor of aldose reductase with an IC50 value of 47 nM in vitro. Through its regulation of glucose metabolism, EBPC has been used to improve the cytotoxic effects of the anticancer agents doxorubicin and cisplatin in HeLa cervical carcinoma cells. EBPC also inhibits prostaglandin F2α (PGF2α) and PGE2 production in human endometrial cells with an EC50 value of 10 μM.

Verwenden

A highly specific aldose reductase inhibitor that has been shown to enhance HeLa cell sensitivity to chemotherapeutic drugs.

ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

ethyl 1-benzyl-3-hydroxy-2(5H)-oxopyrrole-4-carboxylate Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 26)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Hangzhou MolCore BioPharmatech Co.,Ltd. 		+86-057181025280; +8617767106207
 sales@molcore.com China 49734 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788
 jkinfo@jkchemical.com China 94657 76
Tetranov Biopharm 13526569071
 sales@leadmedpharm.com China 7906 64
Chemsky（shanghai）International Co.,Ltd. 021-50135380
shchemsky@sina.com China 32321 50
EMMX Biotechnology LLC 888-539-0666
info@emmx.com United States 8447 60
Shanghai EFE Biological Technology Co., Ltd. 021-65675885 18964387627
 info@efebio.com China 9806 58
Aikon International Limited 025-66113011 13155353615
 qzhang@aikonchem.com China 15394 58
MedBioPharmaceutical Technology Inc 021-69568360 18916172912
 order@med-bio.cn China 8140 58
Energy Chemical 021-58432009 400-005-6266
 marketing@energy-chemical.com China 44918 58

4450-98-0()Verwandte Suche:

  • 1-Ebpc
  • 1H-Pyrrole-3-carboxylic acid, 2,5-dihydro-4-hydroxy-5-oxo-1-(phenylmethyl)-, ethyl ester
  • Nsc 229530
  • 1-Benzyl-4-hydroxy-5-oxo-2,5-dihydro-1H-pyrrole-3-carboxylic acid ethyl ester
  • 1-Benzyl-4-bydroxy-5-oxo-3-pyrroline-3-carboxylic Acid Ethyl Ester
  • 2,5-Dihydro-4-hydroxy-5-oxo-1-(phenylMethyl)-1H-pyrrole-3-carboxylic Acid Ethyl Ester
  • CP-10668
  • Aldose Reductase,inhibit,EBPC,Inhibitor
  • EBPC, Aldose reductase inhibitor
  • 4450-98-0
  • Aromatics
  • Heterocycles
  • Inhibitors
  • Intermediates & Fine Chemicals
  • Pfizer Compounds
  • Pharmaceuticals
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