MMP-8 INHIBITOR I Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
MMP-8 Inhibitor I is a selective inhibitor of the neutrophil collagenase matrix metalloproteinase-8 (MMP-8) with an IC
50 value of 4 nM. This inhibitor does not target the activities of other MMPs
in vitro. MMP-8 cleaves interstitial collagens and has exhibited activity in atherosclerotic plaques, angiogenesis, and stem cell mobilization. Additionally, MMP-8 expression is observed in normal mammary epithelial cells, whereas a loss of expression is observed in human ductal carcinoma
in situ and the deletion of MMP-8 accelerates tumor onset in a mouse model of aggressive breast cancer.
Verwenden
MMP 8-I is a matrix metalloproteinase 8 inhibitor. Matrix metalloproteinases are involved with tight junction protein degradation in endothelial cells.
MMP-8 INHIBITOR I Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
