Ingenol
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- CAS-Nr.
- 30220-46-3
- Englisch Name:
- Ingenol
- Synonyma:
- Ingeno;INGENOL;Inglenook;Ingenol, BR;(-)-Ingenol;Ingenol base;Ingenol >99%;Ingenol USP/EP/BP;INGENOL,HIGHPURITY;Ingenol 30220-46-3
- CBNumber:
- CB4370581
- Summenformel:
- C20H28O5
- Molgewicht:
- 348.43
- MOL-Datei:
- 30220-46-3.mol
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Ingenol Eigenschaften
- Schmelzpunkt:
- 153 °C
- Siedepunkt:
- 523.8±50.0 °C(Predicted)
- Dichte
- 1.33±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Store in freezer, under -20°C
- L?slichkeit
- DMSO: soluble
- Aggregatzustand
- film
- pka
- 12.06±0.70(Predicted)
- Farbe
- colorless
Ingenol Chemische Eigenschaften,Einsatz,Produktion Methoden
R-S?tze Betriebsanweisung:
R38:Reizt die Haut.
R41:Gefahr ernster Augensch?den.
S-S?tze Betriebsanweisung:
S26:Bei Berührung mit den Augen sofort gründlich mit Wasser abspülen und Arzt konsultieren.
S36:DE: Bei der Arbeit geeignete Schutzkleidung tragen.
Beschreibung
Ingenol is a diterpenoid related to phorbol, derived from the milkweed plant E. peplus. It is a protein kinase C activator that displays a K
i value of 30 μM and an ED
50 value of 27 μM
in vitro. Most ingenol esters are tumor-
promoting. However, ingenol mebutate possesses anti-
tumor activity when used topically for actinic keratosis.
Verwenden
Ingenol, is the analogue of Ingenol 3-Angelate (I655800), which has anti-tumor activity when used topically for the treatment of actinic keratosis.
Definition
ChEBI: A tetracyclic diterpenoid that is 1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[e][10]annulen-11-one substituted at positions 5, 5a and 6 by hydroxy groups, positions 1, 1, 7 and 9 by met
yl groups, position 4 by a hydroxymethyl group and position 1 by an oxo group (the 1aR,2S,5R,5aR,6S,8aS,9R,10aR diastere
mer).
Ingenol Upstream-Materialien And Downstream Produkte
Upstream-Materialien
1H-2,8a-Methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one, 4-[(acetyloxy)methyl]-1a,2,5,5a,6,9,10,10a-octahydro-5,5a,6-trihydroxy-1,1,7,9-tetramethyl-, (1aR,2S,5R,5aR,6S,8aS,9R,10aR)-
20-DEOXYINGENOL
Ingenol mebutate
Downstream Produkte
(1aR)-5β,6β-Bis(benzoyloxy)-1aα,2,5,5a,6,9,10,10aα-octahydro-5aβ-hydroxy-4-(hydroxymethyl)-1,1,7,9α-tetramethyl-1H-2α,8aα-methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one
Ingenol Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 236)Lieferanten
30220-46-3()Verwandte Suche:
- 1A,2,5,5A,6,9,10,10A OCTAHYDRO-5,5A,6-TRIHYDROXY4(HYDROXYMETHYL)1,1,7,9-TETRAMETHYL1H-2,8 AMETHANOCYCLOPENTA[A]CYCLOPROPA[E]CYCLODECEN-11 ONE
- 1 ALPHA,2,5,5 ALPHA,6,9,10,10 ALPHA-OCTAHYDRO-5,5 ALPHA,6-TRIHYDROXY-4-HYDROXYMETHYL-1,1,7,9-RETRAMETHYL-1H-2,8 ALPHA-M
- INGENOL
- INGENOL \ ACTIVATES PROTEIN KINASE C
- (1ar,2s,5r,5ar,6s,8as,9r,10ar)-1a,2,5,5a,6,9,10,10a-octahydro-5,5a,6-trihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-1h-2,8a-methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one
- INGENOL,HIGHPURITY
- 1alpha,2,5,5alpha,6,9,10,10alpha-Octahydro-5,5alpha,6-trihydroxy-4-hydroxymethyl-1,1,7,9,-retramethyl-1H-2,8alpha-m
- (1aR,2S,8aS)-1aα,2,5,5a,6,9,10,10aα-Octahydro-5β,5aβ,6β-trihydroxy-4-(hydroxymethyl)-1,1,7,9α-tetramethyl-2,8aα-methano-1H-cyclopenta[a]cyclopropa[e]cyclodecene-11-one
- (1aR,2S,8aS)-1aα,2,5,5a,6,9,10,10aα-Octahydro-5β,5aβ,6β-trihydroxy-4-hydroxymethyl-1,1,7,9α-tetramethyl-1H-2,8aα-methanocyclopenta[a]cyclopropa[e]cyclodecene-11-one
- Ingenol >99%
- Ingenol base
- (1aR,2S,5R,5aR,6S,8aS,9R,10aR)-5,5a,6-Trihydroxy-4-(hydroxymethyl)-1,1,7,9-tetramethyl-1a,2,5,5a,6,9,10,10a-octahydro-1H-2,8a-methanocyclopenta[a]cyclopropa[e][10]annulen-11-one
- 1H-2,8a-Methanocyclopenta[a]cyclopropa[e]cyclodecen-11-one,1a,2,5,5a,6,9,10,10a-octahydro-5,5a,6-trihydroxy-4-(hydroxyMethyl)-1,1,7,9-tetraMethyl-,(1aR,2S,5R,5aR,6S,8aS,9R,10aR)-
- Ingenol 30220-46-3
- HPLC 99% purity Ingenol from Euphorbia lathyris 30220-46-3
- 99% Purity Ingenol Natural Plant Extracts 30220-46-3 Euphorbia Source
- Ingenol, BR
- Ingenol USP/EP/BP
- Inglenook
- (-)-Ingenol
- Ingeno
- Giant Euphorbia Alcohol
- (1S,4S,5R,6R,9S,10R,12R)-4,5,6-trihydroxy-7-(hydroxymethyl)-3,11,11,14-tetramethyltetracyclo[7.5.1.01,5.010,12]pentadeca-2,7-dien-15-one
- 30220-46-3
- BioChemical
- Cell Signaling and Neuroscience
- Cell Biology
- Protein Phosphorylation
- Protein Kinase Activators
- Activator
