2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid

32675-71-1

CAS-Nr.: 32675-71-1

Englisch Name:: 2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid

Synonyma:: (Rac)-RG108;2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid;DNA Methyltransferase Inhibitor - CAS 32675-71-1 - Calbiochem;1H-Indole-3-propanoic acid, α-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-

CBNumber:: CB43372267

Summenformel:: C19H14N2O4

Molgewicht:: 334.33

MOL-Datei:: 32675-71-1.mol

Request For Quotation

Eigenschaften Sicherheit Verwendungswort Produktionsfirma 12

2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid Eigenschaften

Siedepunkt:: 606.0±50.0 °C(Predicted)

Dichte: 1.502±0.06 g/cm3(Predicted)

storage temp.: +2C to +8C

L?slichkeit: DMSO: 100mg/mL
methanol: soluble

Aggregatzustand: Yellow solid

pka: 3.62±0.10(Predicted)

Farbe: yellow

Sicherheit

2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid Chemische Eigenschaften,Einsatz,Produktion Methoden

Allgemeine Beschreibung

A cell-permeable, specific DNA methyltransferases inhibitor (IC₅₀ = 115 nM for CpG methylase M.SssI) that displays anti-proliferative, but not cytotoxic, properties. Unlike the commonly used inhibitor 5-azacytidine, RG108 directly interacts with DNA methyltransferase active site via its carboxy group.

Biochem/physiol Actions

Cell permeable: yes

2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

2-(1,3-Dioxo-1,3-dihydro-2H-isoindol-2-yl)-3-(1H-indol-3-yl)propanoic acid Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 12)Lieferanten

Firmenname	Telefon	E-Mail	Land	Produktkatalog	Edge Rate
ChemStrong Scientific Co.,Ltd	0755-0755-66853366 13670046396	sales@chem-strong.com	China	18110	56
Sigma-Aldrich	021-61415566 800-8193336	orderCN@merckgroup.com	China	51456	80
Zhengzhou Ruike Biochemical Technology Co., Ltd.	18521304688	421551521@qq.com	China	252	58
Changzhou Xianglong Pharmaceutical Technology Co., LTD	0519-88910898 18661161657	yaoxiangqiu2021@163.com	China	9996	58
Yantai Sheng Kai Lun Biological Products Co. , Ltd.	13356901049	mark@sklnchem.cn	China	14376	58
Tan-Mo Technology Co., Ltd.	19850211281	qiann@gbw-china.com	China	1980	58
Nantong Hanfang Biotechnology Co. , Ltd.	18616537568	hanfangpharma@126.com	China	29981	58
Merck KGaA	(+86) 21 2033 8288	sigmaname@qq.com	CHINA	292394	58

2-(1,3-dioxoisoindolin-2-yl)-3-(1H-indol-3-yl)propanoic acid
DNA Methyltransferase Inhibitor - CAS 32675-71-1 - Calbiochem
1H-Indole-3-propanoic acid, α-(1,3-dihydro-1,3-dioxo-2H-isoindol-2-yl)-
(Rac)-RG108
32675-71-1

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