Anti-Forkhead box protein J2 antibody produced in rabbit Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
All Prestige Antibodies Powered by Atlas Antibodies are developed and validated by the Human Protein Atlas (HPA) project
(www.proteinatlas.org)and as a result, are supported by the most extensive characterization in the industry.
The Human Protein Atlas project can be subdivided into three efforts: Human Tissue Atlas, Cancer Atlas, and Human Cell Atlas. The antibodies that have been generated in support of the Tissue and Cancer Atlas projects have been tested by immunohistochemistry against hundreds of normal and disease tissues and through the recent efforts of the Human Cell Atlas project, many have been characterized by immunofluorescence to map the human proteome not only at the tissue level but now at the subcellular level. These images and the collection of this vast data set can be viewed on the Human Protein Atlas (HPA) site by clicking on the Image Gallery link. To view these
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Allgemeine Beschreibung
FOXJ2 (forkhead box J2) is a mammalian fork head transcription factor, which has a wide range of adult tissue expression. It is also expressed during the cleavage stages of pre-implantation development. This protein is composed of 574 amino acids. This gene is localized to human chromosome 12p13.31. Its N- and C-termini contain two tyrosine residues and a region of basic amino acids, which target it to the nucleus, where it is localized. It is alternatively spliced into two variants-FHX.S and FHX.L, with FHK.L being the larger form and the more potent transactivator.
Biochem/physiol Actions
FOXJ2 (forkhead box J2) facilitates the differentiation of endothelial progenitor cells (EPCs), during sheer stress, when acted upon by microRNA-34a (miR-34a). In breast cancer tissues, it controls the EMT (epithelial mesenchymal transition) by controlling E-caherin and vimentin. Thus, it prevents metastasis in breast cancer cells.
Anti-Forkhead box protein J2 antibody produced in rabbit Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
