Anti-myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) Chemische Eigenschaften,Einsatz,Produktion Methoden
Verwenden
Anti-MX1 antibody produced in rabbit has been used in western blotting and ELISA.
Allgemeine Beschreibung
MX1 (Myxoma resistance protein 1) gene is mapped to human chromosome 21q22.3. MX1 is very similar to membrane-remodeling fission GTPases, such as dynamin. The protein has a molecular weight of 70kDa, and contains an amino-terminal globular GTPase domain and a carboxy-terminal stalk domain.
Biochem/physiol Actions
MX1 (Myxoma resistance protein 1) is an interferon-induced dynamin-like GTPase with a broad spectrum antiviral activity. It restricts the replication of many RNA and DNA viruses. At the biochemical level, MX1 proteins bind to intracellular membrane leading to membrane bending and tubulation, also forming dimers and multimeric rings that might interact with the viral structures. MX1 might be associated with pulmonary arterial hypertension pathogenesis, by affecting the BMP (bone morphogenetic proteins)4 and 9 signaling. MX1 serves as an important marker in the diagnosis of dermatomyositis. Genetic variation in MX1 might contribute to systemic lupus erythematosus susceptibility and chronic hepatitis C virus progression.
Anti-myxovirus (influenza virus) resistance 1, interferon-inducible protein p78 (mouse) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
