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KD 5170

KD 5170 Struktur
940943-37-3
CAS-Nr.
940943-37-3
Englisch Name:
KD 5170
Synonyma:
KD 5170;KD5170; KD-5170;KD5170, HDAC inhibitor;S-(2-(6-(4-(3-(DiMethylaMino)propoxy)phenylsulfonaMido)pyridin-3-yl)-2-oxoethyl) ethanethioate;S-(2-{6-[({4-[3-(dimethylamino)propoxy]phenyl}sulfonyl)amino]-3-p Yridinyl}-2-oxoethyl) Ethanethioate;Ethanethioic acid, S-[2-[6-[[[4-[3-(dimethylamino)propoxy]phenyl]sulfonyl]amino]-3-pyridinyl]-2-oxoethyl] ester
CBNumber:
CB42538280
Summenformel:
C20H25N3O5S2
Molgewicht:
451.56
MOL-Datei:
940943-37-3.mol

KD 5170 Eigenschaften

Siedepunkt:
637.9±65.0 °C(Predicted)
Dichte
1.310±0.06 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
L?slichkeit
≥21.2 mg/mL in DMSO with gentle warming; insoluble in H2O; insoluble in EtOH
Aggregatzustand
solid
pka
9.29±0.28(Predicted)
Farbe
White to yellow

Sicherheit

KD 5170 Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

KD 5170 is a mercaptoketone-based inhibitor of class I and II histone deacetylases (HDACs; IC50s = 20, 2,060, 75, 26, 950, 14, 85, 2,500, 150, and 18 nM for HDAC1-10, respectively). It exhibits broad spectrum antitumor activity in vitro and in vivo. KD 5170 increases the acetylation of histones and activates caspases 3, 8, and 9, leading to apoptosis in primary myeloma cells.

KD 5170 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

KD 5170 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 49)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32956 60
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
Career Henan Chemica Co 		+86-0371-86658258 +8613203830695
 laboratory@coreychem.com China 30238 58
Nanjing Doge Biomedical Technology Co., Ltd 		+86-25-58227606 +86-15305155328
 sales@dogechemical.com China 4128 58
LEAPCHEM CO., LTD. 		+86-852-30606658
market18@leapchem.com China 43340 58
Sichuan Biosynce Pharmatech Co., Ltd. 		+8619950309693
 diane@biosynce.com China 4871 58
Aladdin Scientific 		+1-+1(833)-552-7181
sales@aladdinsci.com United States 52924 58
Amadis Chemical Company Limited 		571-89925085
sales@amadischem.com China 131957 58
Chengdu HappySyn Pharmaceutical Technology Co., Ltd. 028-85114309 15881143215
 liangli@happysyn.com China 1860 55
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd. 025-66099280 17798518460
 cfzhang@aikonchem.com China 19915 55
  • KD 5170
  • S-(2-(6-(4-(3-(DiMethylaMino)propoxy)phenylsulfonaMido)pyridin-3-yl)-2-oxoethyl) ethanethioate
  • KD5170; KD-5170
  • S-(2-{6-[({4-[3-(dimethylamino)propoxy]phenyl}sulfonyl)amino]-3-p Yridinyl}-2-oxoethyl) Ethanethioate
  • Ethanethioic acid, S-[2-[6-[[[4-[3-(dimethylamino)propoxy]phenyl]sulfonyl]amino]-3-pyridinyl]-2-oxoethyl] ester
  • KD5170, HDAC inhibitor
  • 940943-37-3
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