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Picamilon

Picamilon  Struktur
34562-97-5
CAS-Nr.
34562-97-5
Englisch Name:
Picamilon
Synonyma:
PIKAMILON;PICAMILON;Pikamiline;Pikamilone;PikamiloneHCl;Picamilon >PICAMILON BASE;NICOTINOYL-GABA;N-Nicotinoyl-GABA;PICAMILON PIKAMILON
CBNumber:
CB4106397
Summenformel:
C10H12N2O3
Molgewicht:
208.21
MOL-Datei:
34562-97-5.mol

Picamilon Eigenschaften

Schmelzpunkt:
211.0 to 215.0 °C
Siedepunkt:
522.4±30.0 °C(Predicted)
Dichte
1.245
storage temp. 
Inert atmosphere,Room Temperature
L?slichkeit
DMSO (Slightly, Heated), Methanol (Slightly)
Aggregatzustand
Solid
pka
4.60±0.10(Predicted)
Farbe
White to Off-White
InChI
InChI=1S/C10H12N2O3/c13-9(14)4-2-6-12-10(15)8-3-1-5-11-7-8/h1,3,5,7H,2,4,6H2,(H,12,15)(H,13,14)
InChIKey
NAJVRARAUNYNDX-UHFFFAOYSA-N
SMILES
C(O)(=O)CCCNC(C1=CC=CN=C1)=O
CAS Datenbank
34562-97-5(CAS DataBase Reference)

Sicherheit

Kennzeichnung gef?hrlicher Xi
HazardClass  IRRITANT
HS Code  2933599590

Picamilon Chemische Eigenschaften,Einsatz,Produktion Methoden

Beschreibung

Picamilon: an analogue of the neurotransmitter γ-aminobutyric acid (GABA)
Picamilon is a derivative of γ-aminobutyric acid (GABA) and nicotinic acid developed in 1970 by the All-Union Vitamin Research Institute to increase central nervous system (CNS) levels of γ-aminobutyric acid (GABA). Drugs that can mimic or increase GABA activity in the brain have the potential to provide anti-anxiety and anti-convulsive effects. GABA itself, when consumed orally, does not cross the blood-brain barrier. Much research has, therefore, been devoted to developing orally active agents that have GABA-like effects. Both gabapentin (a GABA analogue) and picamilon were designed to be orally administered drugs that cross the blood-brain barrier and provide inhibitory CNS effects. Picamilon, prescribed in dosages from 50 mg to 200 mg, can cross the blood-brain barrier in animal models and, once in the CNS, is hydrolyzed into GABA and nicotinic acid. The released GABA could potentially have inhibitory properties, including anti-anxiety and anti-convulsant effects. Nicotinic acid would also be released, potentially leading to dilation of CNS blood vessels. The FDA has never approved picamilon for use in the USA, but picamilon is used in Russia to treat various neurological conditions[1].

Verwenden

anti-cancer agent

Picamilon Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


Picamilon Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 178)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
Hebei Yanxi Chemical Co., Ltd.
+8617531153977
allison@yan-xi.com China 5856 58
Hubei xin bonus chemical co. LTD
86-13657291602
linda@hubeijusheng.com CHINA 22963 58
Chongqing Chemdad Co., Ltd
+86-023-6139-8061 +86-86-13650506873
sales@chemdad.com China 39894 58
CONIER CHEM AND PHARMA LIMITED
+8618523575427
sales@conier.com China 49374 58
Zhengzhou Alfa Chemical Co.,Ltd
+8618530059196
sale04@alfachem.cn China 11849 58
Hebei Mujin Biotechnology Co.,Ltd
+86 13288715578 +8613288715578
sales@hbmojin.com China 12831 58
SIMAGCHEM CORP
+86-13806087780
sale@simagchem.com China 17365 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000
marketing@targetmol.com United States 32161 58
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418671 +8618949823763
sales@tnjchem.com China 34563 58
AFINE CHEMICALS LIMITED
+86-0571-85134551
sales@afinechem.com China 15352 58

34562-97-5()Verwandte Suche:


  • 4-((Pyridine-3-carbonyl)-amino)-butyric acid
  • Pikamiline
  • PikamiloneHCl
  • 3-[(3-Carboxypropyl)carbamoyl]pyridine
  • PIKAMILON
  • 4-Nicotinoylamino-butylric acid
  • PIKAMILONE HYDROCHLORIDE
  • NICOTINOYL-GABA
  • N-(3-CARBOXYPROPYL) NICOTINAMIDE
  • 4-[(PYRIDIN-3-YLCARBONYL)AMINO]BUTANOIC ACID
  • 4-(NICOTINAMIDO)BUTANOIC ACID
  • 4-(3-PYRIDYLCARBOXAMIDO)BUTYRIC ACID
  • 4-[(3-PYRIDINYLCARBONYL)AMINO]BUTANOIC ACID
  • 4-Nicotinoylamino-butyric acid
  • Pikamilone
  • Pikamilone sodium sale
  • 4-Nicotinoylamino-butanoic acid
  • PikaMilone, 4-NicotinoylaMino-butyric acid
  • Butanoic acid,4-[(3-pyridinylcarbonyl)aMino]-
  • PICAMILON BASE
  • 4-(pyridine-3-carbonylamino)butanoic acid
  • 4-[[oxo(3-pyridinyl)methyl]amino]butanoic acid
  • Nicotinoyl-γ-aminobutyric Acid
  • Picamilon >
  • N-Nicotinoyl-gamma-aminobutyric Acid
  • N-Nicotinoyl-GABA
  • 4-(Nicotinamido)butyric Acid
  • PICAMILON PIKAMILON
  • PICAMILON
  • Pikamilone, 10 mM in DMSO
  • 34562-97-5
  • Other APIs
  • API
  • Chemistry
  • Heterocycles
  • 34562-97-5
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