RIZ1 (human recombinant) Chemische Eigenschaften,Einsatz,Produktion Methoden
Beschreibung
Retinoblastoma protein-
interacting zinc finger protein 1 (RIZ1), also known as PRDM2, is a SAM-
dependent histone methyltransferase that specifically methylates histone H3 on lysine 9. RIZ1 contains 8 zinc-
finger motifs and 1 PR domain. The RIZ gene encodes two different proteins, RIZ1 and RIZ2. RIZ1 is a tumor suppressor that can arrest the cell cycle and induce apoptosis. RIZ2 however, is a proto-
oncoprotein lacking the N-
terminal PR domain containing the methyltransferase activity. When RIZ1 is silenced or mutated, the reduced methyltransferase activity can lead to inheritable changes in chromatin methylation and gene expression patterns.
RIZ1 (human recombinant) Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
