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Succinimides

Succinimides Struktur
CAS-Nr.
Englisch Name:
Succinimides
Synonyma:
Succinimides
CBNumber:
CB31316336
Summenformel:
Molgewicht:
0
MOL-Datei:
Mol file

Succinimides Eigenschaften

Sicherheit

Succinimides Chemische Eigenschaften,Einsatz,Produktion Methoden

Mechanism of action

Succinimides suppress the paroxysmal 3-Hz spike-and-wave activity associated with the lapses of consciousness associated with absence (petite mal) seizures, thus reducing the frequency of seizures and raising the threshold to seizures. The proposed mechanism of action involves a decrease in T-type calcium channel activity.
Succinimides are indicated for the monotherapy of absence seizures or with concomitant therapy when additional forms of seizures occur in combination with absence seizures. These drugs are readily absorbed from the gastrointestinal tract and display very low protein binding. The drug interactions for the succinimides are less extensive than with the oxazolidinediones. They may increase plasma phenytoin levels, decrease plasma primidone levels, and either increase or decrease valproate levels, although the changes may not be clinically significant.

Clinical Use

The clinically used succinimides include ethosuximide, methsuximide, and phensuximide, which were introduced between 1951 and 1958 and widely accepted for the treatment of absence seizures.

Succinimides Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte


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