4-(4-Aminophenoxy)-N-methylpicolinamide
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- CAS-Nr.
- 284462-37-9
- Englisch Name:
- 4-(4-Aminophenoxy)-N-methylpicolinamide
- Synonyma:
- 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide;4-(4-Aminophenoxy)-N-methylpyridine-2-carboxamide;SL-M2;Sorafen;Sorafenib INT2;Sorafenib impurity A;Sorafenib Intermediate;Sorafenib tosylate INT III;Sorafenib Related Compound 23;[4-(4-Aminophenoxy-2-pyridyl)]
- CBNumber:
- CB31175425
- Summenformel:
- C13H13N3O2
- Molgewicht:
- 243.26
- MOL-Datei:
- 284462-37-9.mol
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4-(4-Aminophenoxy)-N-methylpicolinamide Eigenschaften
- Schmelzpunkt:
- 110-112°C
- Siedepunkt:
- 476.8±40.0 °C(Predicted)
- Dichte
- 1.241±0.06 g/cm3(Predicted)
- Dampfdruck
- 0.001-0.05Pa at 20-109.84℃
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- L?slichkeit
- DMSO (Slightly), Methanol (Slightly)
- pka
- 13.96±0.46(Predicted)
- Farbe
- White to Light yellow to Light orange
- LogP
- 0.9 at 25℃ and pH7
- Oberfl?chenspannung
- 71.71mN/m at 883.8mg/L and 20.1℃
4-(4-Aminophenoxy)-N-methylpicolinamide Chemische Eigenschaften,Einsatz,Produktion Methoden
Chemische Eigenschaften
Light-Brown Solid
Verwenden
Sorafenib intermediate
Synthese
To a solution of 4-aminophenol (1 g, 9.2 mmol) in DMF (20 mL) was added 1M potassium ier/-butoxide in THF (9.7 mL, 9.7 mmol) at room temperature. After 2h, (4-chloro(2-pyridyl))-N- methyl carboxamide (1.6 g, 9.2 mmol) and potassium carbonate (0.64 g, 4.6 mmol) were added, and then the reaction mixture was heated to 80 °C for 6h. After cooling, the reaction mixture was extracted with ethyl acetate (50 mL). The organic layer was washed with brine (20 mL) and dried over magnesium sulfate. The solvent was removed in vacuo. The residue was purified by column chromatography to afford 4-(4-Aminophenoxy)-N-methylpicolinamide (2.2 g, 80 %) as a light-brown solid.
4-(4-Aminophenoxy)-N-methylpicolinamide Upstream-Materialien And Downstream Produkte
Upstream-Materialien
Downstream Produkte
4-(4-Aminophenoxy)-N-methylpicolinamide Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.
Global( 430)Lieferanten
284462-37-9()Verwandte Suche:
- 4-(4-aMiNApheNAxy)-N-MethylpicolinaMide
- 4-(4-aMinophenoxy)-N-MethylpicolinaMide oxalate
- N-Methyl-4-(4-aMinophenoxy)pyridine-2-carboxaMide
- 4-(4- aMinophenoxy)-N- Methyl-2- pyridineforMaMide
- 4-(4-Aminophenyloxy)-N-methyl-2-pyridininecarboxamide
- Sorafenib INT2
- 4-(4-aminophenoxy)-N-methylpyridine-2-carboxamide oxalate
- 4-(4-Aminophenoxy)-N-methylpicolinamide
- 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]anilin
- 4-[[2-(N-Methylcarbamoyl)-4-pyridyl]oxy]aniline
- [4-(4-Aminophenoxy-2-pyridyl)]
- 4-(4-AMino-phenoxy)-pyridine-2-carboxylicacidMethylaMide
- 4-(4-AMinophenoxy)-pyridine-2-carboxylic acid aMide
- 4-(4-Aminophenoxy)-N-methylpicolimide
- [4-(4-Aminophenoxy-2-pyridyl)]-2-methylcarboxamide
- Sorafenib impurity A
- Sorafenib Intermediate
- Sorafenib Related Compound 23
- Sorafen
- Sorafenib Aminophenoxy Impurity
- Sorafenib tosylate INT III
- N-Methyl-4-(4-aminophenoxy)pyridine-2-carboxamide Sorafenib Intermediates II
- 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide >
- 2-Pyridinecarboxamide, 4-(4-aminophenoxy)-N-methyl-
- 4-(2-N-METHYLCARBOMOYL)-4-PYRIDYLOXY)ANILINE
- 4-(4-Aminophenoxy)-N-methylpicolinamide ISO 9001：2015 REACH
- 4-(4-Aminophenoxy)-N-methylpicolinamide (Sorafenib Impurity)
- 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide
- 4-(4-Aminophenoxy)-N-methylpyridine-2-carboxamide
- SL-M2
- 4-(4-Aminophenoxy)-N-methyl-2-pyridinecarboxamide (IP2014)
- 284462-37-9
- C13H13N3O2C2H2O4
- Sorafinib
- Aromatics Compounds
- Aromatics
- Bases & Related Reagents
- Heterocycles
- Nucleotides
- Sorafenib tosylate
- 284462-37-9
