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YC-1

YC-1 Struktur
170632-47-0
CAS-Nr.
170632-47-0
Englisch Name:
YC-1
Synonyma:
YC-1;CS-2261;Nsc728165;LIFICIGUAT;Lificiguat(YC-1);YC-1(Lificiguat);YC 1 (pharMaceutical);YC-1, guanylyl cyclase activator;YC-1 - CAS 170632-47-0 - Calbiochem;1-Benzyl-3-(5-hydroxymethylfur-2-yl)indazole
CBNumber:
CB2395371
Summenformel:
C19H16N2O2
Molgewicht:
304.34
MOL-Datei:
170632-47-0.mol

YC-1 Eigenschaften

Schmelzpunkt:
110-112℃
Siedepunkt:
522.2±50.0 °C(Predicted)
Dichte
1.24±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
L?slichkeit
DMSO: 12 mg/mL
pka
13.83±0.10(Predicted)
Aggregatzustand
solid
Farbe
white
Stabilit?t:
Stable for 2 years from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 3 months.
Sicherheit
  • Risiko- und Sicherheitserkl?rung
  • Gefahreninformationscode (GHS)
WGK Germany  3
Bildanzeige (GHS) GHS hazard pictograms
Alarmwort Warnung
Gefahrenhinweise
Code Gefahrenhinweise Gefahrenklasse Abteilung Alarmwort Symbol P-Code
H302 Gesundheitssch?dlich bei Verschlucken. Akute Toxizit?t oral Kategorie 4 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P270, P301+P312, P330, P501
H315 Verursacht Hautreizungen. Hautreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P302+P352, P321,P332+P313, P362
H319 Verursacht schwere Augenreizung. Schwere Augenreizung Kategorie 2 Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" /> P264, P280, P305+P351+P338,P337+P313P
H335 Kann die Atemwege reizen. Spezifische Zielorgan-Toxizit?t (einmalige Exposition) Kategorie 3 (Atemwegsreizung) Warnung GHS hazard pictogramssrc="/GHS07.jpg" width="20" height="20" />
Sicherheit
P261 Einatmen von Staub vermeiden.
P305+P351+P338 BEI KONTAKT MIT DEN AUGEN: Einige Minuten lang behutsam mit Wasser spülen. Eventuell vorhandene Kontaktlinsen nach M?glichkeit entfernen. Weiter spülen.

YC-1 Chemische Eigenschaften,Einsatz,Produktion Methoden

Verwenden

YC-1 has been used as a hypoxia-inducible factor 1α (HIF-1α) inhibitor:
  • to reduce hypoxia induced Jagged1 expression in cardiomyocytes (CMs)
  • to study its effect on progenitor expansion and CD34+ and side population (SP) cell phenotype and on the proliferation rate of cells with an ability to form long term colony forming units
  • to study its effect on regulating sphingosine 1-phosphate (S1P) bound to albumin induced plasminogen activator inhibitor 1 (PAI-1) expression by activating Rho/ Rho-associated protein kinase (ROCK) pathway.

Allgemeine Beschreibung

A nitric oxide-independent, superoxide-sensitive activator of soluble guanylyl cyclase. Inhibits platelet adhesion to collagen and acts as an antithrombotic agent. Reported to reduce HIF-1α levels and xenograft growth.

Biochem/physiol Actions

YC-1 activates soluble guanylyl cyclase and prevents platelet aggregation and vascular contraction. It has a potential to treat circulation disorders. YC-1 also has an ability to inhibit hypoxia-inducible factor 1α (HIF-1α) activity in vitro. It acts as a potential antiangiogenic anticancer agent.

YC-1 Upstream-Materialien And Downstream Produkte

Upstream-Materialien

Downstream Produkte

YC-1 Anbieter Lieferant Produzent Hersteller Vertrieb H?ndler.

Global( 129)Lieferanten
Firmenname Telefon E-Mail Land Produktkatalog Edge Rate
ATK CHEMICAL COMPANY LIMITED 		+undefined-21-51877795
ivan@atkchemical.com China 32956 60
Alchem Pharmtech,Inc. 		8485655694
sales@alchempharmtech.com United States 63687 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000
 marketing@targetmol.com United States 32161 58
HANGZHOU CLAP TECHNOLOGY CO.,LTD 		86-571-88216897,88216896 13588875226
 sales@hzclap.com CHINA 6312 58
InvivoChem 		+1-708-310-1919 +1-13798911105
 sales@invivochem.cn United States 6391 58
Nanjing Doge Biomedical Technology Co., Ltd 		+86-25-58227606 +86-15305155328
 sales@dogechemical.com China 4128 58
Nantong HI-FUTURE Biology Co., Ltd. 		+undefined18051384581
 sales@chemhifuture.com China 3135 58
TargetMol Chemicals Inc.
support@targetmol.com United States 38631 58
ShenZhen Trendseen Biological Technology Co.,Ltd. 		13417589054
 trendseenbio@gmail.com China 11681 58
Wuhan Topule Biopharmaceutical Co., Ltd 		+8618327326525
 masar@topule.com China 8467 58

170632-47-0()Verwandte Suche:

  • 2-Furanmethanol, 5-[1-(phenylmethyl)-1H-indazol-3-yl]-
  • Nsc728165
  • (5-(1-Benzyl-1H-indazol-3-yl)furan-2-yl)Methanol
  • YC 1 (pharMaceutical)
  • 1-Benzyl-3-(5-hydroxymethylfur-2-yl)indazole
  • 1-benzyl-3-(5-hydroxymethyl-furan-2-yl)indazole
  • Lificiguat(YC-1)
  • 5-[1-(PHENYLMETHYL)-1H-INDAZOL-3-YL]-2-FURANMETHANOL
  • 3-(5'-HYDROXYMETHYL-2'-FURYL)-1-BENZYLINDAZOLE
  • LIFICIGUAT
  • YC-1
  • YC-1 (3-(5'-HYDROXYMETHYL-2'-FURYL)-1-BE NZYL INDAZOLE) \ GUANYLYL CYCLASE ACTI
  • 1-benzyl-3-(5-hydroxymethyl-2-furyl)indazole
  • YC-1 - CAS 170632-47-0 - Calbiochem
  • CS-2261
  • YC-1(Lificiguat)
  • YC-1, guanylyl cyclase activator
  • 170632-47-0
  • C19H16N2O2
  • Cell Signaling and Neuroscience
  • Cell Biology
  • BioChemical
  • Cyclic Nucleotide Metabolism
  • G Proteins and Cyclic Nucleotides
  • Guanylyl Cyclase Activators
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